PedAM
Pediatric Disease Annotations & Medicines
| Disease | hyperglycemia |
| Phenotype | C0011847|diabetes |
| Sentences | 383 |
| PubMedID- 21139669 | It is highly probable that the hyperglycemia in diabetes leads to an array of metabolic changes, many of which may be directed toward limitation or repair of the damage. |
| PubMedID- 25325279 | hyperglycemia in patients with type 2 diabetes is caused by multiple defects, including insulin resistance, impaired insulin secretion, and excessive hepatic glucose production. |
| PubMedID- 20836897 | Multiple and complex pathways promote the deleterious effects of hyperglycemia in diabetes, ultimately leading to micro- and macrovascular disease. |
| PubMedID- 21266043 | Chronic hyperglycemia in diabetes, through the nonenzymatic glycation of free amino groups in proteins by glucose, leads to the formation of labile schiff base intermediates that undergo amadori rearrangement, leading to the relatively stable early adducts ketoamine or fructosamine (so-called amadori products). |
| PubMedID- 25918533 | A 30-year-old obese male patient had been diagnosed with diabetes mellitus due to acute hyperglycemia and ketonuria. |
| PubMedID- 23737732 | This mouse spontaneously exhibits type 2 diabetes, associated with mild hyperglycemia, mild glucose intolerance, mild hyperinsulinemia, mild obesity, and mild microalbuminuria. |
| PubMedID- 23220949 | Effect of additional administration of acarbose on blood glucose fluctuations and postprandial hyperglycemia in patients with type 2 diabetes mellitus under treatment with alogliptin. |
| PubMedID- 25883713 | Therefore, dpp-4 inhibitors may be useful in the management of hyperglycemia in patients with glucocorticoids-induced diabetes, which is characterized by normal or mild increase in fasting plasma glucose levels and a remarkable increase in postprandial glucose levels. |
| PubMedID- 26287417 | A ppb-r-203-based diet reduced postprandial hyperglycemia in patients with type 2 diabetes without increasing the risk of hypoglycemia or glucose excursion. |
| PubMedID- 23670996 | It is hoped that targeting therapy at the metabolic perturbations underlying hyperglycemia in patients with type 2 diabetes will have a similar benefit (27). |
| PubMedID- 25298619 | diabetes is associated with hyperglycemia and increased thrombin production. |
| PubMedID- 26198996 | Conclusions: following colorectal operations, superficial ssi, sepsis, and death are associated with postoperative serum hyperglycemia in patients without diabetes, but not those with diabetes. |
| PubMedID- 25950009 | Increased formation of glyoxal and methylglyoxal and oxidative stress in hyperglycemia associated with diabetes has been linked to microvascular complications—including diabetic nephropathy [1, 35]. |
| PubMedID- 21410975 | Exenatide twice daily (exenatide bid) was the first glp-1 receptor agonist approved for treatment of hyperglycemia in patients with type 2 diabetes not adequately controlled with diet and exercise, sulfonylurea (sfu), tzd, or metformin (met; alone, or with an sfu, or tzd). |
| PubMedID- 26114112 | In response to hyperglycemia in patients with diabetes, various metabolic mechanisms contribute to the pathogenesis of diabetic complications. |
| PubMedID- 22524271 | Diets based on refined carbohydrate foods that are quickly digested, absorbed, and metabolized (i.e., high glycemic index diets) have been associated with increased risk of lifestyle diseases in particular with an increased risk of type 2 diabetes, because of postprandial hyperglycemia and hyperinsulinemia related to eating high-gi carbohydrates. |
| PubMedID- 21659759 | Their importance as downstream mediators of hyperglycemia in diabetes has been amply demonstrated in studies using mechanistically different inhibitors of advanced glycation to retard the development of kidney disease without directly influencing plasma glucose levels. |
| PubMedID- 20668682 | The gk rats are a model of type ii diabetes that presents with hyperglycemia but without severe hyperlipidemia. |
| PubMedID- 21457068 | Relationship among a1c, hypoglycemia, and hyperglycemia in japanese with type 2 diabetes--results from continuous glucose monitoring data. |
| PubMedID- 24907624 | diabetes was associated with weight loss, hyperglycemia, and oxidative stress as reflected by increased serum malondialdehyde (mda) concentrations. |
| PubMedID- 21772974 | Uncontrolled diabetes with hyperglycemia has been suggested as a possible mechanism for osteoporosis in both type 1 and type 2. this can occur by the formation of nonenzymatic glycosylation of various bone proteins, including type 1 collagen, leading to impaired bone quality [61]. |
| PubMedID- 23758078 | The objective of this study was to evaluate the feasibility of using telemedicine to improve glycemic control (reduce episodes of hypoglycemia and severe hyperglycemia) for residents with diabetes in a skilled nursing facility. |
| PubMedID- 22332001 | The hyperglycemia associated with type 2 diabetes also appears to impair gap junctional communication between astrocytes as shown in (1) cultured astrocytes harvested from 1-day-old wistar-hanover rats and exposed to high glucose, and (2) brain slices from 20-to-24-week-old stz rats [72]. |
| PubMedID- 23755276 | Chronic hyperglycemia in diabetes is associated with cardiovascular disease and microvascular pathologies in the retina, kidney and peripheral nerves [1], [2]. |
| PubMedID- 25810947 | Due to the hyperglycemia associated with diabetes, enhanced formation of reactive oxygen occurs, which contributes to the increased neuronal death by oxidizing proteins, damaging dna, and augmenting lipid peroxidation [10, 65]. |
| PubMedID- 20009088 | The influence on the ubiquitin-proteasome system of hyperglycemia associated with diabetes in this regard has yielded seemingly contradictory results. |
| PubMedID- 26253538 | Secondly, we sought to investigate the effect of glp-1 modulation on myocardial function in the setting of hyperglycemia in patients with type 2 diabetes mellitus (t2dm). |
| PubMedID- 24319123 | Conclusions: these results suggest vulnerability of the developing brain in young children to effects of type 1 diabetes associated with chronic hyperglycemia and glucose variability. |
| PubMedID- 24408841 | In vitro studies suggest hyperglycemia associated with diabetes impair embryogenesis but in vivo investigations on maternal hyperglycemic insult and early embryo development are scarce. |
| PubMedID- 23099862 | Furthermore, experimental suppression of hyperglucagonemia corrects postprandial hyperglycemia in individuals with type 2 diabetes (7). |
| PubMedID- 21193621 | A subsequent study further demonstrated that diabetes distress covaried with hyperglycemia over time, but depressive symptoms and mdd did not (7). |
| PubMedID- 24843469 | Chronic hyperglycemia in diabetes can therefore induce persistent er stress, cause β‐cell dysfunction and finally lead to a reduction in β‐cell mass through apoptosis1. |
| PubMedID- 23882051 | However, reducing hyperglycemia in individuals with type 2 diabetes has not been clearly associated with a decreased risk of developing cancer (49,50). |
| PubMedID- 26141922 | hyperglycemia in diabetes mellitus causes glycation of membrane enzymes along with oxidative stress leading to decrease in activity of na+/k+-atpase and other changes in erythrocyte membranes [1]. |
| PubMedID- 23565389 | Despite an increasing number of therapeutic options, optimal management of hyperglycemia in patients with type 2 diabetes (t2d) remains an elusive goal for a majority of patients. |
| PubMedID- 22920280 | The five cases not adjudicated as diabetes included three cases of subthreshold hyperglycemia (table 3; defined in table 2), one case of diabetes with onset before t0, and one case of polycystic ovarian syndrome. |
| PubMedID- 24324521 | The hyperglycemia in diabetes produces superoxide anions, which generate hydroxyl radicals, promoting cell membrane damages as a result of lipid peroxidation and protein glycation of membrane [18]. |
| PubMedID- 22496878 | We have recently identified selenoprotein p (sep) as a liver-derived secretory protein that causes insulin resistance and hyperglycemia in patients with type 2 diabetes [1]. |
| PubMedID- 23649520 | hyperglycemia in patients with type 2 diabetes is resolved shortly after roux-en-y gastric bypass (rygb), suggesting that mechanisms independent of weight loss contribute to the improvement in glycemic control (1–4). |
| PubMedID- 23346258 | In the absence of insulin, glucose uptake from peripheral tissues is inhibited; thus hyperglycemia occurs, leading to diabetes, and fat becomes the energy source of the organism via gluconeogenesis [65]. |
| PubMedID- 24671137 | For diabetes control, poor = dm2 with hba1c≥7% and hyperglycemia, and good = dm2 with hba1c<7% and euglycemia; p values estimated by student t test for continuous variables, or chi-square for discrete variables (when cell count n>5) or fisher’s exact (when cell count n≤5); p values ≤0.099 have gray highlight and p values ≤0.05 are shown in bold; bmi, body-mass index; sd, standard deviation. |
| PubMedID- 21713092 | The three major metabolic abnormalities that contribute to hyperglycemia in diabetes mellitus are defective glucose-induced insulin secretion, increased hepatic glucose output and inability of insulin to stimulate glucose uptake in the peripheral target tissues. |
| PubMedID- 22837722 | Metformin is a biguanide drug that is broadly used in clinical practice to prevent hyperglycemia in patients with diabetes mellitus. |
| PubMedID- 22096320 | [29] in hyperglycemia associated with diabetes, the use of aldose reductase inhibitors has shown efficacy in attenuating diabetic complications. |
| PubMedID- 23415113 | Dapagliflozin, a highly selective inhibitor of sglt2, has demonstrated efficacy, alone or in combination with metformin, in reducing hyperglycemia in patients with type 2 diabetes [35,36]. |
| PubMedID- 25596527 | Glut4 function is impaired in obesity and type 2 diabetes leading to hyperglycemia and an increased risk of cardiovascular disease and neuropathy. |
| PubMedID- 23074234 | Objective: our objective was to observe the optimal management of hyperglycemia in patients with diabetes or impaired glucose tolerance receiving renal transplantation. |
| PubMedID- 22615627 | Antioxidant activity of rhus coriaria could also be useful for prevention of diabetes complications due to hyperglycemia (11)figure 1. |
| PubMedID- 21394317 | Steroid is associated with the risk of hyperglycemia in patients with or without diabetes (10, 11). |
| PubMedID- 20508223 | It is interesting that pain and dysesthesias may precede the development of type 2 diabetes, and that with hyperglycemia or elevated free fatty acid levels there is increased flux through the mitochondrial respiration chain leading to increased oxidant stress, with elevated levels of superoxide production, and a consequent increase in production of metabolites such as dihydroxyacetone phosphate, which is converted into the age precursor methylglyoxal (mg). |