PedAM
Pediatric Disease Annotations & Medicines
| Disease | hyperglycemia |
| Phenotype | |diabetes |
| Sentences | 383 |
| PubMedID- 21977459 | Diabetic polyneuropathy (dpn) is one of the microvascular complications of diabetes that is attributed to chronic hyperglycemia and is a common cause of morbidity in patients with diabetes mellitus [5]. |
| PubMedID- 24332968 | Beta cell failure in type 2 diabetes (t2d) is associated with hyperglycemia, but the mechanisms are not fully understood. |
| PubMedID- 24843713 | In japan, several cases of severe hyperglycemia in patients with type 2 diabetes after initiation of the glp‐1 receptor agonist, liraglutide, as replacement for insulin were reported15. |
| PubMedID- 22701470 | The direct impact of hyperglycemia-induced vasodilation in patients with type 1 diabetes is not certain. |
| PubMedID- 22010455 | The patient presented symptoms of diabetes with extreme hyperglycemia >1600 mg/dl and nonketotic hyperosmolar coma. |
| PubMedID- 23264428 | Unexplained hyperglycemia in a patient with type 1 diabetes may suggest impending dka, and monitoring of ketones should therefore be performed. |
| PubMedID- 23339473 | As ogtts should be avoided in patients with severe diabetes because of the risk of hyperglycemia, the homeostasis model assessment of insulin resistance (homa-ir) index is widely used in clinical practice and in clinical studies instead [4]. |
| PubMedID- 22235198 | The inbred mouse strain kk/ta, established as a diabetic strain in japan, spontaneously exhibits characteristics of type 2 diabetes associated with fasting hyperglycemia, glucose intolerance, hyperinsulinemia, mild obesity, dyslipidemia, and albuminuria. |
| PubMedID- 21152193 | The hyperglycemia associated with diabetes can lead to modifications of macromolecules, for example, ldl, by forming advanced glycation end products (age), which can bind to surface receptors, such as rage (receptor for ages) [42]. |
| PubMedID- 20299466 | (13) provided evidence that posthypoglycemic hyperglycemia in patients with type 1 diabetes is the result of counterregulatory hormonal response to hypoglycemia in concert with prevalent plasma insulin concentration, and that all of the hormones but glucagon may play a role. |
| PubMedID- 23657005 | There may be evidence to clarify why unabsorbable carbohydrates improve postprandial hyperglycemia in diabetes patients [3], which is also the mechanism that explains the effects of tgd. |
| PubMedID- 25352436 | In response to hyperglycemia in patients with diabetes, many signaling pathways contribute to the pathogenesis of diabetic complications, including diabetic retinopathy (dr). |
| PubMedID- 22590838 | Perioperative hyperglycemia is common in patients with type 2 diabetes undergoing coronary artery bypass graft (cabg) surgery and there is a direct relation between postoperative hyperglycemia and mortality rate in these patients. |
| PubMedID- 24843599 | hyperglycemia in diabetes is due to the insufficient action of insulin, and cognitive impairment is not only closely associated with hyperglycemia, but also with the action of insulin. |
| PubMedID- 23890278 | Stress-induced diabetes, with hyperglycemia and ir, during acute hospitalization is a hallmark of severely burned patients and a common pathophysiological phenomenon [4]. |
| PubMedID- 21502328 | Results: fifteen percent of cf patients had glucose intolerance and 6% had diabetes without fasting hyperglycemia and 3% had diabetes with fasting hyperglycemia. |
| PubMedID- 26379785 | Chronic hyperglycemia in diabetes mellitus is known to induce numerous chronic complications including micro- and macrovascular injuries, whose diagnosis is often hampered by silent or minor clinical presentation. |
| PubMedID- 24729889 | Chronic hyperglycemia resulting from diabetes brings about a rise in oxidative stress due to overproduction of reactive oxygen species (ros) as a result of glucose-autoxidation and protein glycosylation. |
| PubMedID- 21357363 | Since 1995 there have been multiple new drugs approved by the food and drug administration for the treatment of hyperglycemia in patients with type 2 diabetes, including the biguanide metformin, α-glucosidase inhibitors, thiazolidinediones, glinides, glp-1 analogs, amylin analogs, dipeptidyl peptidase-iv inhibitors (31), a bile acid sequestrant (32), and most recently a dopamine receptor agonist (33). |
| PubMedID- 19833883 | Such examples are cdk4-deficient (32,33) or cyclin d2–deficient (18,34) mice; both models have a progressive reduction of β-cell number and gross onset of diabetes with features of hyperglycemia and glucose intolerance. |
| PubMedID- 21852673 | Furthermore, experimental diabetes in rats with insulinopenia and hyperglycemia provokes mucosal hypertrophy and increases mrna and protein expression of glut2, glut5, and sglt1 (16). |
| PubMedID- 23471910 | For example, hyperglycemia in diabetes causes oxidative stress, but might also have direct effects on endothelial dysfunction. |
| PubMedID- 24396690 | In 1992, it was first revealed that acute intravenous glp-1 infusion (for 30 or 210 minutes) significantly reduced postprandial hyperglycemia in patients with type 2 diabetes [1,2]. |
| PubMedID- 22618776 | Msc infusion ameliorated hyperglycemia in rats with type 2 diabetes (t2d). |
| PubMedID- 25767499 | Moreover, hyperglycemia in diabetes mellitus can induce hippocampal blood capillary injury, leading to regional ischemia and elevated bad expression levels[2324]. |
| PubMedID- 22238392 | Context: dapagliflozin, a selective sodium-glucose cotransporter 2 (sglt2) inhibitor, reduces hyperglycemia in patients with type 2 diabetes mellitus (t2dm) by increasing urinary glucose excretion, and weight loss is a consistent associated finding. |
| PubMedID- 24939606 | Chronic hyperglycemia in diabetes is associated with profound changes in lipid and lipoprotein metabolism, with resultant alterations in particle distribution within lipoprotein classes. |
| PubMedID- 25349949 | Conclusion: depression in type 2 diabetes was closely associated with hyperglycemia and hypoglycemia, which might be partly mediated through poor treatment adherence. |
| PubMedID- 23573479 | Male kk/ta mice spontaneously exhibit type 2 diabetes associated with hyperglycemia, glucose intolerance, hyperinsulinemia, mild obesity and microalbuminuria, conditions which are more severe than those found in the female (2-4). |
| PubMedID- 26246777 | Evidence from observational studies indicates that inpatient hyperglycemia, in patients with and without diabetes, is associated with increased risks of complications and mortality. |
| PubMedID- 24790413 | Basal-bolus insulin therapy is an ideal regimen for improving uncontrolled hyperglycemia in patients with diabetes mellitus.1 prandial premixed insulin therapy (ppt), injected three times a day, is also effective for glycemic control in type 2 diabetics.2–9 further, ppt is convenient for patients, because it requires only a single insulin preparation. |
| PubMedID- 24250607 | Several drugs such as sulfonylureas and biguanides are presently available to reduce hyperglycemia in diabetes mellitus. |
| PubMedID- 21896927 | A history of type 1 diabetes manifestation with acute hyperglycemia and ketonuria; type 1 diabetes of <3 months duration; positive results for at least two of the three islet antibodies, glutamic acid decarboxylase, protein tyrosine phosphatase, or islet cell antibodies; and residual basal fasting c-peptide of >0.1 nmol/l (for two of the studies) and >0.2 nmol/l (for the other two studies) were required for subjects to be enrolled (11–13). |
| PubMedID- 23835327 | It has been established that ca(v)3.2 t-type voltage-gated calcium channels (t-channels) play a key role in the sensitized (hyperexcitable) state of nociceptive sensory neurons (nociceptors) in response to hyperglycemia associated with diabetes, which in turn can be a basis for painful symptoms of peripheral diabetic neuropathy (pdn). |
| PubMedID- 23826343 | These in vitro results support out findings in vivo and further imply that hyperglycemia associated with diabetes leads to elevation in erbb2 expression and activity that ultimately mediates vascular dysfunction. |
| PubMedID- 23315305 | The clinical management of hyperglycemia in patients with type 2 diabetes mellitus (t2dm) is guided not only by published treatment algorithms, but also by consideration of recent evidence and through consultation with colleagues and experts. |
| PubMedID- 22844269 | Prolonged exposure to chronic hyperglycemia in diabetes can lead to various complications affecting the cardiovascular, renal, neurological, and visual systems [2]. |
| PubMedID- 22585309 | Beyond hyperglycemia in diabetes: role of statin treatment on thrombogenesis triggered by inflammation: editorial to: "impact of statins on the coagulation status of type 2 diabetes patients evaluated by a novel thrombin-generations assay" by p. |
| PubMedID- 26167540 | hyperglycemia in diabetes mellitus causes oxidative stress and pericyte depletion from the microvasculature of the brain thus leading to the blood-brain barrier (bbb) disruption. |
| PubMedID- 24790595 | Of great clinical interest, synthetic ligands of pparγ, belonging to the class of thiazolidinediones (tzds), such as troglitazone, pioglitazone, and rosiglitazone, function as insulin sensitizers and are used for treating hyperglycemia in patients with type 2 diabetes [7, 18–20]. |
| PubMedID- 25239210 | Constant hyperglycemia in individuals with type 2 diabetes can cause microvascular and macrovascular complications that lead to early morbidity and mortality. |
| PubMedID- 20150286 | Despite their hyperglycemia, patients with type 2 diabetes tend to have elevated fasting glucagon levels and exaggerated glucagon responses to meal ingestion (5). |
| PubMedID- 23691290 | Increase in tnf-α and il-6 during diabetes may be due to hyperglycemia related to oxidative stress and inflammation [83]. |
| PubMedID- 23243444 | Chronic hyperglycemia in diabetes is associated with long-term damage, dysfunction, and eventually the failure of organs, especially eyes, kidneys, nerves, and the cardiovascular system [11–13]. |
| PubMedID- 24947195 | Mononuclear invasion of langerhans islet and the ensuing insulitis triggers signal-transduction for the autoimmune mediated pancreatic beta-cell (beta-cell) apoptosis that severely disrupts insulin production resulting in hyperglycemia associated with type-1 diabetes (t1dm). |
| PubMedID- 23320026 | hyperglycemia associated with diabetes mellitus can be controlled by diet management, exercise, oral hypoglycemic agents, and insulin therapy. |
| PubMedID- 20425570 | Although multiple drugs exist for treating the hyperglycemia associated with diabetes, few have been shown to reduce cardiovascular risk. |
| PubMedID- 22923999 | hyperglycemia in diabetes results from defects in insulin secretion, insulin action, or, most commonly, both. |
| PubMedID- 26340671 | Moreover, the function of bm stem cells may be affected by hyperglycemia associated with diabetes [7]. |
| PubMedID- 22224063 | [1] chronic hyperglycemia during diabetes causes glycation of body proteins that in turn leads to secondary complications disturbing eyes, kidneys, nerves, and arteries. |