PedAM
Pediatric Disease Annotations & Medicines
| Disease | hyperglycemia |
| Phenotype | |diabetes |
| Sentences | 383 |
| PubMedID- 21193630 | Unexplained hyperglycemia in a patient with type 1 diabetes may suggest impending dka, and monitoring of ketones should therefore be performed. |
| PubMedID- 24695667 | Important early findings in incretin biology include proof-of-concept studies showing glp-1 infusion improves hyperglycemia in patients with type 2 diabetes [3] and cloning of the glp-1r cdna [4]. |
| PubMedID- 23785354 | diabetes showing hyperglycemia, oxidative stress, and hyperhomocysteinemia deteriorates bone material properties in terms of collagen post-translational modification such as enzymatic immature and mature cross-links and non-enzymatic ages formation. |
| PubMedID- 21286019 | Glucocorticoids not only exacerbate hyperglycemia in patients with known diabetes mellitus (dm), but also cause dm in patients without documented hyperglycemia before the initiation of glucocorticoid therapy (2). |
| PubMedID- 22807634 | This process of nonenzymatic glycation is exacerbated in diabetes due to chronic hyperglycemia and accompanying reactive carbonyl stress. |
| PubMedID- 22111038 | It is well established that chronic hyperglycemia in patients with type 2 diabetes mellitus causes progressive deterioration of β-cell function. |
| PubMedID- 23882045 | The importance of avoiding prolonged hyperglycemia in patients with short diabetes duration in order to minimize its negative effect on late microvascular and macrovascular complications has been established (11). |
| PubMedID- 20678212 | The current study further documents that even mild hyperglycemia consistent with pre-diabetes is related to higher complication rates in patients over the age of 65. |
| PubMedID- 26197936 | These inconsistencies may be due to the extent and duration of hyperglycemia as patients with type 2 diabetes may remain undiagnosed and therefore untreated for years, whereas the rats in this study were only diabetic for a period of 4 weeks. |
| PubMedID- 24153424 | Throughout the course of the disease, the vast majority of subjects develop symptoms of diabetes, including hyperglycemia, elevated triglycerides, low levels of high-density lipoprotein, and increase in blood pressure and waist circumference (figure 1). |
| PubMedID- 22529472 | [12] it has been reported that the increasing of os during diabetes, largely due to hyperglycemia, causes neuropathy as a diabetic complication. |
| PubMedID- 22055501 | The role of hyperglycemia in cad associated with type 2 diabetes is less clear. |
| PubMedID- 26060538 | One approach used to control hyperglycemia in patients with diabetes is the use of agents such as acarbose, which inhibits α-glucosidase activity and subsequently impairs the digestion of carbohydrates and delays glucose absorption after a meal [4]. |
| PubMedID- 23378622 | In early diabetes, before the onset of microalbuminuria, mild hyperglycemia and activation of the intrarenal renin-angiotensin-aldosterone system (raas) may lead to oxidative stress at the postglomerular capillary level (25,26). |
| PubMedID- 24379274 | It has also been found that serum vap-1 was elevated in acute and chronic hyperglycemia and in patients with diabetes as well as in chronic kidney disease. |
| PubMedID- 22864290 | On multivariate analysis, stress hyperglycemia in patients without diabetes was an independent predictor of msi. |
| PubMedID- 24151186 | hyperglycemia in diabetes enhances the accumulation of ages in the np and triggers disc degeneration. |
| PubMedID- 26244639 | Non-enzymatic glycation or maillard reaction is known to be a significant contributor to the onset of hyperglycemia-induced pathologies associated with diabetes, and perhaps the chronic pathologies associated with aging and neurodegeneration [39]. |
| PubMedID- 24735134 | Conclusions: opt2mise will represent the largest studied homogeneous cohort of type 2 diabetes patients with persistent hyperglycemia despite optimized mdi therapy. |
| PubMedID- 23448719 | Persistent hyperglycemia in diabetes can result in sustained levels of neuronal glucose up to fourfold in healthy individuals and lead to glucose neurotoxicity.46 it is therefore tempting to speculate that the lower systemic glycemia and significantly improved ability to respond to glucose challenge in ω-3pufa-fed animals may contribute, in part, to the protective effects of ω-3pufas on neuronal function. |
| PubMedID- 26504840 | In 2013, chinese hospital association (cha) set up a systematic management program of hyperglycemia in inpatients with type 2 diabetes (t2d) admitted to top tertiary hospital to improve the care of inpatients with t2d in china and, in particular, to learn the profile of hypoglycaemia and associated factors. |
| PubMedID- 21562080 | We hypothesize that hyperglycemia in diabetes impairs hypothalamic glucose sensing to lower glucose production, and changes of glucose transporter-1 (glut1) in the hypothalamic glial cells are responsible for the deleterious effects of hyperglycemia in vivo. |
| PubMedID- 23761972 | Sitagliptin (januvia [merck, whitehouse station, nj, usa]) is a highly selective dipeptidyl peptidase-4 (dpp-4) inhibitor available for the treatment of hyperglycemia in patients with type 2 diabetes,40,41 and simvastatin (zocor™ [merck]) is an hmg-coa reductase inhibitor available as an adjunctive treatment to diet for reducing elevated ldl-c and other lipids in patient with primary hypercholesterolemia and is indicated for reducing the risk of cardiovascular mortality.42 an fdc tablet of sitagliptin and simvastatin (juvisync™ [merck]) has been approved and provides an option for use in patients for whom treatment with both sitagliptin and simvastatin is appropriate. |
| PubMedID- 23264286 | At the onset, kpd often appears as type 1 diabetes with acute hyperglycemia and ketosis or ketoacidosis and the obvious need for insulin therapy but the signs of autoimmunity against islet β-cells are absent. |
| PubMedID- 23470218 | Chronic hyperglycemia in patients with diabetes is associated with a myriad of harmful complications. |
| PubMedID- 21792376 | hyperglycemia resulting from diabetes has an adverse impact on embryonic development through induction of apoptosis in mice embryonic tissues [108]. |
| PubMedID- 23439632 | Lack of suppression of glucagon is known to contribute to postprandial hyperglycemia in diabetes (25), and, contrary to our expectation, bariatric surgery did not restore this defect. |
| PubMedID- 23522691 | Depression is associated with hyperglycemia in diabetes, which in turn, increases the risk of diabetic complications such as retinopathy, neuropathy and nephropathy [38,39]. |
| PubMedID- 22439599 | hyperglycemia in patients with type 2 diabetes places them at significant risk for cardiovascular events and other diabetic complications [2], as shown for example by the united kingdom prospective diabetes study (ukpds 35), which demonstrated a strong association between the risk of diabetic complications and hyperglycemia [3]. |
| PubMedID- 24250559 | Uncontrolled chronic hyperglycemia in diabetes leads to severe complications including neuropathy, retinopathy, and autonomic dysfunctions. |
| PubMedID- 22777596 | Cortical location of the lesion, hemorrhagic transformation, and hyperglycemia in patients without diabetes are important predictors of es. |
| PubMedID- 26003073 | The patients were divided into groups based on glucose tolerance categories in the oral glucose tolerance test (impaired glucose tolerance - igt, cystic fibrosis related diabetes without fasting hyperglycemia - cfrd fh(-) or with fasting hyperglycemia - cfrd fh(+)). |
| PubMedID- 21085649 | However, newer data reveal that hyperketonemia or diabetic ketoacidosis can also co-exist with hyperglycemia in patients with type 2 diabetes [52]. |
| PubMedID- 23816355 | Exercise has been widely recognized to ameliorate insulin resistance and hyperglycemia in individuals with type 2 diabetes mellitus (t2dm) [1,2]. |
| PubMedID- 21715522 | However, postprandial glucose may contribute less to overall glycemic control than preprandial glucose in patients with diabetes, and the role of postprandial hyperglycemia as an independent cardiovascular risk factor is still uncertain (22). |
| PubMedID- 25878764 | In support, the pathophysiologic perturbations connected with obesity-related diabetes are robustly associated with hyperglycemia-induced oxidative stress [5, 6]. |
| PubMedID- 20046232 | The vascular and systemic complications in diabetes are associated with hyperglycemia-induced overproduction of reactive oxygen species 8,9. |
| PubMedID- 23378612 | Chronic hyperglycemia leads to development of diabetes-associated microvascular, macrovascular, and neurologic complications, which can be delayed by intensive insulin therapy (1). |
| PubMedID- 20519662 | Because we observed that cognitive decline was greater in prevalent diabetic patients than in incident diabetic patients and individuals without diabetes, duration of exposure to hyperglycemia could be the main factor that induces and maintains cognitive decline. |
| PubMedID- 22745639 | It is well known that diabetes is associated with hyperglycemia, elevated oxidative and carbonyl stress, and low tissue and plasma levels of gsh [115–120], conditions that complicate the diabetic state, which would lead to further exacerbation of gsh loss. |
| PubMedID- 26015297 | In addition to hyperglycemia, patients with type 2 diabetes have hyperinsulinemia as a result of insulin-resistance. |
| PubMedID- 21159853 | After extending previous evidence that leptin infusion directly into the lateral cerebral ventricle ameliorates hyperglycemia in rats with streptozotocin-induced uncontrolled diabetes mellitus, we showed that the underlying mechanism is independent of changes of food intake, urinary glucose excretion, or recovery of pancreatic beta-cells. |
| PubMedID- 24734255 | Besides chronic hyperlipidemia and hyperglycemia, patients with diabetes display an increased ratio of oxidized ldl over native ldl [94–96]. |
| PubMedID- 24076121 | hyperglycemia-induced oxidative stress leads to diabetes-associated damage to the microvasculature of the brain. |
| PubMedID- 22973412 | Chronic hyperglycemia exposes patients with type 1 diabetes to an increased risk for death if left untreated. |
| PubMedID- 23961474 | [3940] religious requirements, which mandate practices like fasting etc., plays a role in limiting patients’ ability to comply with medical advice on proper diabetes care[41] leading to hyperglycemia, diabetic ketoacidosis, dehydration and thrombosis. |
| PubMedID- 20028938 | From a fasting ffa of 0.4 ± 0.3 mmol/l in diabetic subjects and 0.4 ± 0.3 mmol/l in control subjects, ffa levels increased to 1.5 ± 1.1 mmol/l in kpdm, 1.9 ± 0.4 mmol/l in obese type 2 diabetes with hyperglycemia, and 1.8 ± 1.1 mmol/l in nondiabetic control subjects at the end of intralipid infusion, respectively (p = ns difference between groups at baseline or during intralipid infusion). |
| PubMedID- 22454632 | hyperglycemia in diabetes also stimulates toll-like receptor (tlr) signaling, which results in prolonged inflammation and tissue damage. |
| PubMedID- 24672797 | The hyperglycemia in diabetes is associated with an increased risk for plasma hypercoagulability [3]. |
| PubMedID- 21193614 | Furthermore, a vicious cycle might occur in individuals with established diabetes of osa leading to hyperglycemia, requiring increasing glucose-lowering treatment, which could in turn cause weight gain and worsen the sleep apnea. |