PedAM
Pediatric Disease Annotations & Medicines
| Disease | hyperglycemia |
| Phenotype | |diabetes |
| Sentences | 383 |
| PubMedID- 23209008 | Finally, it attempts to integrate these mechanisms into the schema of pathophysiological factors that combine to produce hyperglycemia in patients with diabetes mellitus. |
| PubMedID- 25812084 | Metformin is a drug used to decrease hyperglycemia in patients with type-2 diabetes, in part by activating ampk and is currently under investigation as a potential treatment for several types of cancer [101, 102]. |
| PubMedID- 24876449 | Background: vascular dysfunction due to hyperglycemia in individuals with diabetes is a factor contributing to distal symmetric polyneuropathy (dspn). |
| PubMedID- 24615580 | [36] neutropenia, diabetes with blood hyperglycemia and low ph, fe overload, corticosteroid therapy, and direct inoculation as a result of trauma are the main risk factors. |
| PubMedID- 22211582 | Efficacy of protamine zinc recombinant human insulin for controlling hyperglycemia in dogs with diabetes mellitus. |
| PubMedID- 22474580 | Thus, hyperglycemia associated with diabetes may alter the normal regulation of bone and lead to increased adiposity resulting in compromised bone quality. |
| PubMedID- 26343954 | Enhanced oxidative stress and hyperglycemia are associated with diabetes mellitus (dm). |
| PubMedID- 22071577 | diabetes mellitus, a state of persistent hyperglycemia, is a major cause of micro- and macrovascular diseases. |
| PubMedID- 24375463 | Introduction: hyperglycemia associated with diabetes mellitus (dm) has adverse impacts on peripheral nerve connective tissue structure, and there is preliminary evidence that nerve biomechanics may be altered. |
| PubMedID- 21876346 | At week 16 of diabetes, rats with equivalent hyperglycemia and albuminuria were randomized into groups which received no treatment, vehicle alone or a selective jnk inhibitor (cc-930, 60 mg/kg/bid) for 10 weeks. |
| PubMedID- 26562793 | According to the recent studies, hyperglycemia associated with diabetes plays the role of stabilizing the collagen network through giving rise to cross-linking of collagen network in the aortic wall media. |
| PubMedID- 23009606 | Regarding the mechanism involved in this association, it seems that prolonged hyperglycemia associated with diabetes causes the formation of advanced glycation end-products (age). |
| PubMedID- 21318185 | Only a handful of genes have been shown to affect development of hyperglycemia in diabetes mouse models. |
| PubMedID- 22247912 | Although the kidney becomes a victim of hyperglycemia in diabetes mellitus, recent work has shown that the abnormalities of lipid and glucose metabolism in the kidney are similarly important to those in adipose tissue. |
| PubMedID- 23363608 | Due to unrecognized diabetes complicated with infection, extreme hyperglycemia, even hyperglycemic hyperosmolar state or diabetic ketoacidosis, may occur. |
| PubMedID- 24858947 | hyperglycemia resulting from type 2 diabetes mellitus (t2dm) is the main cause of diabetic complications such as retinopathy and neuropathy. |
| PubMedID- 24616659 | The consequences of poor glucose homeostasis are well-known: hyperglycemia associated with uncontrolled diabetes can lead to cardiovascular disease, neuropathy and nephropathy, while hypoglycemia can lead to convulsions, loss of consciousness, coma, and even death. |
| PubMedID- 22446165 | Recent work reveals that hyperglycemia in diabetes triggers nutrient excess in neurons that, in turn, mediates a phenotypic change in mitochondrial biology through alteration of the amp-activated protein kinase (ampk)/peroxisome proliferator-activated receptor gamma coactivator-1alpha (pgc-1alpha) signaling axis. |
| PubMedID- 22548951 | Objective: to observe the effect of the dawn phenomenon on basal glucose and postbreakfast hyperglycemia in patients with type 1 diabetes treated with once-nightly insulin glargine and premeal insulin lispro. |
| PubMedID- 23880900 | When starting bedtime insulin in type 2 diabetes patients, those with fasting type hyperglycemia are prone to greater weight gain. |
| PubMedID- 20548844 | Typical symptoms of diabetes due to hyperglycemia (polyphagia, polyuria, and weight loss) were found in 63.3% of the young group, while they were found only in 29.9% of the older group (p < 0.05). |
| PubMedID- 24159092 | The hyperglycemia in diabetes may impose cellular stress on the retina. |
| PubMedID- 23841037 | The risk of microalbuminuria is correlated with plasma glucose level, and the duration of hyperglycemia in patients with diabetes (9, 10). |
| PubMedID- 23734259 | Metabolic stress, such as chronic hyperglycemia in diabetes, is known to increase the production of reacting oxygen species (ros) and promote inflammatory gene expression, accelerating vascular aging [1]. |
| PubMedID- 20587056 | hyperglycemia associated with type 1 diabetes can activate nf-κb [45], which is known to induce b1r [9,10]. |
| PubMedID- 26001054 | Studies have demonstrated that an episode of transient hyperglycemia in diabetes can induce epigenetic changes that result in lasting changes in gene expression, i.e. |
| PubMedID- 20513244 | Chronic hyperglycemia in diabetes can lead to various complications, affecting the cns [3]. |
| PubMedID- 24471104 | Therefore, antioxidants can prevent pathological damage caused by hyperglycemia-induced oxidative stress associated with diabetes (7). |
| PubMedID- 25663437 | To mimic hyperglycemia in diabetes patients, the influence of elevated glucose levels on the actions of the different growth factors was also studied: ibrec were cultivated for 3 days in medium containing 3 g/l (≈17 mm) d-glucose instead of the normal 1 g/l (≈5.6 mm) d-glucose before vegf-a165 and vegf-b were added. |
| PubMedID- 22805998 | Using this model of maternal diabetes, with hyperglycemia moderated by twice daily insulin, we previously described significantly enhanced aortic contractility and endothelial dysfunction in female but not male offspring 17. we therefore sought to extend studies in this model to determine whether offspring exposed to short-term (7-day) maternal hyperglycemia in utero would display sex-specific increased blood pressure. |
| PubMedID- 22114719 | However, by one month after birth, transgenic mice expressing any of the three ran variants exhibited overt diabetes, with hyperglycemia, reduced insulin production, and nearly complete loss of islet number and islet mass, in vivo. |
| PubMedID- 24455476 | diabetes is associated with hyperglycemia and this has been shown to have a direct effect on mitochondrial function [172]. |
| PubMedID- 23506302 | The modifications induced by maternal diabetes may be attributed to hyperglycemia and fetal hyperinsulinemia, which affect lipid and protein synthesis [30]. |
| PubMedID- 21307777 | Aim: hyperglycemia in diabetes mellitus (dm) may be one of the most important factors responsible for the development of oxidative stress, which promotes the main complications in dm patients. |
| PubMedID- 24808678 | [5] complications due to hyperglycemia in diabetes mellitus can be prevented by using rational use of oral antidiabetic drugs (oads) and insulin. |
| PubMedID- 21655098 | Although egb761 has beneficial effects on blood circulation and hyperglycemia in patients with diabetes, direct studies on its effects against atherosclerosis are limited. |
| PubMedID- 23633864 | The oxidative degradation of fructosamines may contribute to the oxidative stress found in hyperglycemia associated with diabetes mellitus. |
| PubMedID- 20876728 | The systemic metabolic disturbances of diabetes, including hyperglycemia and hyperlipidemia, likely play a central role in the pathogenesis of diabetes-associated atherosclerosis through the generation of oxidative stress. |
| PubMedID- 24296718 | A transgenic mouse model that expresses a constitutively active mutant of human ikk2 dependent on pdx-1 promoter activity (ikk2-ca(pdx-1)) spontaneously develops full-blown immune-mediated diabetes with insulitis, hyperglycemia, and hypoinsulinemia. |
| PubMedID- 21217061 | hyperglycemia in diabetes mellitus promotes oxidative stress in endothelial cells, which contributes to development of cardiovascular diseases. |
| PubMedID- 23116444 | The term diabetic cardiomyopathy refers to a state of cardiac dysfunction independent of associated coronary artery disease that arises within weeks of hyperglycemia (hg) leading to longer term diabetes mellitus (dm) [1]. |
| PubMedID- 22187469 | As retinopathy is estimated to take at least 5 years to develop after the onset of hyperglycemia, patients with type 1 diabetes should have an initial dilated and comprehensive eye examination within 5 years after the onset of diabetes. |
| PubMedID- 21941533 | diabetes initiated due to hyperglycemia has a wide spectrum of disease manifestations as it leads to increased susceptibility of oxidative stress ultimately damaging various organs [12–16]. |
| PubMedID- 22778984 | It is well established that the chronic hyperglycemia associated with diabetes directly damages the microcirculation, leading to small vessel dysfunction [5]. |
| PubMedID- 21775756 | However, the failure to completely normalize fasting hyperglycemia in patients with type 2 diabetes appears to be consistent with both clinical practice and previous clinical studies (14) and provides a rationale for adding complimentary treatment options, such as short-acting insulin (24) or incretin-based therapies (25), if normoglycemia cannot be achieved with basal insulin alone. |
| PubMedID- 24550684 | The initial stage of development of nephropathy, incipient nephropathy, is characterized by the onset of persistent microalbuminuria and hyperfiltration.3 over the years the mechanisms of hyperglycemia leading to diabetes complications, specifically nephropathy, have been deciphered, but not totally. |
| PubMedID- 24465132 | When contraindications to its use exist or patients cannot tolerate it due to adverse effects, clinicians have a variety of other classes of agents to treat hyperglycemia associated with type 2 diabetes mellitus. |
| PubMedID- 23231438 | In clinical trials, both exenatide formulations reduced hyperglycemia in patients with type 2 diabetes mellitus (t2dm) and were associated with weight loss. |
| PubMedID- 25409255 | diabetes was strongly associated with hyperglycemia (table 2). |
| PubMedID- 25050258 | hyperglycemia during diabetes results in cognition impairment. |