PedAM
Pediatric Disease Annotations & Medicines
| Disease | hyperglycemia |
| Phenotype | |diabetes |
| Sentences | 383 |
| PubMedID- 25181406 | The aims of the study were to compare the glycemic control achieved by using sliding-scale or basal-bolus regimens for the management of severe or acute hyperglycemia in patients with type 2 diabetes and to analyze factors associated with the types of insulin therapy used in the management of severe or acute hyperglycemia. |
| PubMedID- 23199039 | Evidence is also available indicating that endothelial dysfunction precedes the development of overt hyperglycemia in patients with type 2 diabetes [15]. |
| PubMedID- 26355954 | hyperglycemia in diabetes causes tissue damage through various mechanisms and contributes to diabetic complications (1). |
| PubMedID- 25560829 | hyperglycemia associated with type 1 diabetes is a consequence of immune-mediated destruction of insulin producing pancreatic beta-cells. |
| PubMedID- 24341330 | The persistent hyperglycemia in patients with type 2 diabetes mellitus is strongly associated with microvascular and macrovascular complications [1]. |
| PubMedID- 22611498 | Many of the metabolic conditions associated with diabetes, including hyperglycemia, excess free fatty acid liberation, and insulin resistance mediate abnormalities in endothelial cell function by affecting the synthesis or degradation of no [99]. |
| PubMedID- 20484139 | Elevated hgp caused by defective suppression of gluconeogenesis is one of the primary defects contributing to fasting hyperglycemia in patients with type 2 diabetes (2–4). |
| PubMedID- 20130740 | Therefore, these results suggest that hps3 may partly ameliorate hyperglycemia and hyperlipidemia associated with type 2 diabetes through increased insulin secretion, inhibition of lipid peroxidation, promotion of sensitivity to insulin, suppression of gluconeogenesis and reduction in the biosynthesis fatty acid, cholesterol and cell cytokines related to insulin resistance, and it could be a useful adjunct therapy to a proven first-line therapy for type 2 diabetes using metformin. |
| PubMedID- 23717171 | Under certain pathologic conditions (e.g., oxidative stress due to hyperglycemia in patients with diabetes), age formation can be increased beyond normal levels. |
| PubMedID- 25651730 | Umbilical cord mesenchymal stem cell transfusion ameliorated hyperglycemia in patients with type 2 diabetes mellitus. |
| PubMedID- 26587047 | Nevertheless, in a randomized, blinded, crossover study, a single oral dose of quercetin (400 mg) effectively suppressed postprandial hyperglycemia in patients with type 2 diabetes [105]. |
| PubMedID- 23614630 | The position statement on the management of hyperglycemia in patients with type 2 diabetes mellitus issued in 2012 by the american diabetes association and the european association for the study of diabetes contains significant improvements over the 2009 version, including an emphasis on patient-centered care, enhanced strategies for lifestyle modification, a focus on comprehensive cardiovascular risk reduction, and increased pharmacotherapy choices. |
| PubMedID- 22489155 | diabetes mellitus patients with long-term hyperglycemia produce more ofr due to increased glucose autoxidation and protein saccharification, which weakens oxidation resistance and initiates oxidation stress [22]. |
| PubMedID- 25905210 | The hyperglycemic hyperosmolar state (hhs) is a life-threatening metabolic decompensation of diabetes which presents with severe hyperglycemia and profound dehydration, typically accompanied by alteration in consciousness ranging from lethargy to coma. |
| PubMedID- 20427697 | By these means, the hyperglycemia in patients with type 2 diabetes can readily be normalized by the intravenous administration of glp-1 (26), even at relatively low doses (27). |
| PubMedID- 24963915 | Based on these studies and our current results, we propose that high glucose or hyperglycemia in diabetes shifts mitochondrial dynamics to fission, leading to mitochondrial fragmentation, which sensitizes mitochondria to bax attack, cytochrome c release and apoptosis during acute injury. |
| PubMedID- 20971966 | Given that a lack of suppression of glucagon secretion contributes to hyperglycemia in individuals with type 2 diabetes (47), the development of a physiologically regulated human α-cell line may have significant utility as a screening tool for the identification of novel therapeutics that suppress glucagon secretion. |
| PubMedID- 22355231 | Long standing diabetes with uncontrolled hyperglycemia is known to cause increased nonenzymatic glycation of proteins. |
| PubMedID- 21470936 | Whether or not the elevated risk is moderated by the degree of control of the hyperglycemia associated with diabetes will need to be determined in future studies. |
| PubMedID- 25849026 | hyperglycemia in diabetes stimulates the increase in tgfβ-1 expression and, in turn, induces kidney multi-cellular hypertrophy through autocrine and paracrine pathways. |
| PubMedID- 25961051 | hyperglycemia is common in patients with diabetes in hospital and several guidelines have suggested using basal and prandial subcutaneous (s.c.) insulin in non-critically ill patients as first-choice pharmacological treatment to ensure the best possible glycemic control, combined with an appropriate nutrition scheme [1–5]. |
| PubMedID- 22247866 | Several drugs such as biguanides and sulfonylureas are presently available to reduce hyperglycemia in diabetes mellitus. |
| PubMedID- 20435798 | Objective: hospital hyperglycemia, in individuals with and without diabetes, has been identified as a marker of poor clinical outcome in cardiac surgery patients. |
| PubMedID- 24348460 | On the other hand, were unable to relate polymorphisms of pyruvate dehydrogenase kinase four gene, a mitochondrial kinase attributing to hyperglycemia, with mets or diabetes in korean (49). |
| PubMedID- 26528798 | Skeletal muscle is the principal site for postprandial glucose utilization and augmenting the rate of glucose utilization in this tissue may help to control hyperglycemia associated with diabetes mellitus. |
| PubMedID- 24264410 | Indeed, in the setting of fully developed diabetes with frank hyperglycemia it appears more likely that this isoform should not be interfered with. |
| PubMedID- 22573917 | The chronic hyperglycemia resulting from poorly controlled diabetes can prime neutrophils and monocytes, resulting in an exaggerated inflammatory response and tissue damage. |
| PubMedID- 22811666 | Endothelial cell dysfunction, an early vascular complication in diabetes, has been associated with hyperglycemia-induced oxidative stress. |
| PubMedID- 21886908 | From the previous results, it was concluded that the presence of type 2 diabetes mellitus-induced hyperglycemia results in significant increase in lipid profile, oxidative stress markers and inflammatory mediators in patients with non alcoholic fatty liver disease and normal liver function tests. |
| PubMedID- 23826312 | Uncontrolled or poorly regulated hyperglycemia in diabetes causes serious metabolic dysregulation, including hyperlipidemia, hypercholesterolemia, ketosis, impaired liver function, liver damage, weight loss, and development of cataracts. |
| PubMedID- 24495364 | Background: type 2 diabetes along with chronic hyperglycemia may result in cognitive impairment. |
| PubMedID- 20923484 | In women, postprandial hyperglycemia was associated with shorter diabetes duration and higher preprandial blood glucose concentration, whereas postprandial hypoglycemia was associated with higher physical activity. |
| PubMedID- 23295502 | Clinical trial results have shown further that two glp-1 receptor agonists (glp-1 ras), exenatide and liraglutide, which are approved for the treatment of hyperglycemia in patients with type 2 diabetes, also produce weight loss in overweight subjects without diabetes. |
| PubMedID- 23576884 | Background: the purpose of this paper is to review the efficacy, safety, and tolerability of linagliptin in the management of hyperglycemia in adults with type 2 diabetes mellitus. |
| PubMedID- 23185367 | Hepatic overproduction of glucose is a prominent contributor to hyperglycemia in patients with type 2 diabetes, and this overproduction may be a consequence of chronic and postprandial hyperglucagonemia [33], [34]. |
| PubMedID- 25633683 | Postprandial hyperglycemia is common in patients with type 2 diabetes (t2dm) [3,4]. |
| PubMedID- 26055217 | Dipeptidyl peptidase-4 (dpp-4) inhibitors increase active glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) by inhibiting dpp-4 enzymatic activity, and improve hyperglycemia in patients with diabetes in a glucose-dependent manner by increasing insulin secretion [2]. |
| PubMedID- 24137241 | This rat model successfully imitated human type ii diabetes, with moderate hyperglycemia, hypertension, dyslipidemia and insulin resistance. |
| PubMedID- 21354306 | hyperglycemia in patients with type 2 diabetes causes multiple neuronal complications, e.g., diabetic polyneuropathy, cognitive decline, and embryonic neural crest defects due to increased apoptosis. |
| PubMedID- 21523218 | The chronic hyperglycemia associated with diabetes leads to long-term complications including cvd, nephropathy leading to renal failure, retinopathy with potential loss of vision, and peripheral neuropathy (27). |
| PubMedID- 22649411 | In hyperglycemia, as with diabetes mellitus and metabolic syndrome, high activity of the krebs cycle due to high substrate availability may increase the h+ gradient over the mitochondrial membrane (figure 2a), leading to inhibition of enzymatic steps mediated by complexes within the electron transport chain, including succinate dehydrogenase (complex ii; figure 2a; brownlee, 2005). |
| PubMedID- 24772447 | But this ability of the endocrine pancreas seems to be attenuated in type 2 diabetes which finally leads to hyperglycemia and blood glucose fluctuations [1–3]. |
| PubMedID- 22154739 | We hypothesized that et-1-induced vasoconstriction is augmented in type 2 diabetes with hyperglycemia through an increment in advanced glycation end-products (ages). |
| PubMedID- 21464945 | Insulin deficiency or resistance as well as hyperglycemia in patients with diabetes are known risk factors for metabolic bone diseases, including osteoporosis [29]. |
| PubMedID- 20811038 | The former is thought to be relevant to the pathogenesis of iatrogenic hypoglycemia and the latter to that of hyperglycemia in diabetes (12,13,40). |
| PubMedID- 23193216 | Pizza is widely recognized to cause marked late postprandial hyperglycemia in patients with type 1 diabetes (11). |
| PubMedID- 20978101 | Noninvasive assessment of exercise-related intramyocellular acetylcarnitine in euglycemia and hyperglycemia in patients with type 1 diabetes using (1)h magnetic resonance spectroscopy: a randomized single-blind crossover study. |
| PubMedID- 25456647 | Sglt2 inhibition offers a novel mechanism to mitigate hyperglycemia in patients with diabetes and the introduction of sglt2 has added a significant new tool to the antihyperglycemic armamentarium. |
| PubMedID- 20334663 | Potential agents to target postprandial hyperglycemia in patients with type 2 diabetes include α-glucosidase inhibitors and glinide drugs. |
| PubMedID- 23202020 | Several clinical studies have demonstrated that the long-term diabetes complications, due to hyperglycemia, and the frequency of risky short-term complications, due to hypoglycemia, could be reduced through a therapy based on a mix of diet, physical exercise, and drug delivery (including subcutaneous injections of exogenous insulin), tuned according to the monitoring of individual parameters [1]. |