PedAM
Pediatric Disease Annotations & Medicines
| Disease | hyperglycemia |
| Phenotype | |diabetes |
| Sentences | 383 |
| PubMedID- 22135215 | hyperglycemia in diabetes causes increased oxidative stress in the vascular endothelium with generation of free radicals such as superoxide. |
| PubMedID- 23620811 | Here, we provide novel evidence that chronic aicar-induced ampk activation in vivo did not reduce hyperglycemia in rats with stz-induced diabetes, although it enhanced glycogen accumulation and fatty acid oxidation in white muscles and potently reduced circulating nefa and tg levels in these animals. |
| PubMedID- 23454717 | Non-enzymatic glycation, which refers to the spontaneous binding of reducing sugars to free amino groups, is increased in diabetes mellitus because of hyperglycemia and is amplified by oxidative processes ('glycoxidation'). |
| PubMedID- 26581389 | The major novelty of this study is that experimentally induced acute hyperglycemia with no preceding diabetes diminishes cardioprotective effect of riperc. |
| PubMedID- 21525431 | These results suggest that hyperglycemia in diabetes downregulated trpc6 protein expression in mcs through a nadph oxidase nox4-ros-pkc pathway, proving a mechanism for impaired mc contraction in diabetes. |
| PubMedID- 25847066 | diabetes involves the state of chronic hyperglycemia caused by a range of genetic and environmental factors, and it is widely considered as one of the risk factors for periodontal disease (1). |
| PubMedID- 25995968 | On the basis of all the research articles used for this review, it is reasonable to propose that naw may offer a potent and complete oral therapy for treatment of t2d patients, and also for those patients who have higher risk of developing diabetes due to overweight, hyperglycemia, and hypertension. |
| PubMedID- 25633134 | Among the many complications of type 2 diabetes mellitus (t2dm) arising from prolonged hyperglycemia, as well as from comorbid conditions such as hypertension, is chronic kidney disease (ckd), which is present in up to 40% of patients with t2dm [1]. |
| PubMedID- 20042777 | Unexplained hyperglycemia in a patient with type 1 diabetes may suggest impending dka, and monitoring of ketones should therefore be performed. |
| PubMedID- 24843720 | hyperglycemia in diabetes is usually associated with accelerated age formation. |
| PubMedID- 21307380 | Ages, increased in diabetes as a result of both hyperglycemia and oxidative stress, are observed in both myelinated and unmyelinated fibers of sural, peroneal, and saphenous nerves of individuals with diabetes (6,7) and may contribute to the segmental demyelination of diabetic neuropathy (8). |
| PubMedID- 24154684 | The mechanisms responsible for hyperglycemia with new onset diabetes are not clear, but are likely due to the combination of impaired insulin secretion and insulin resistance. |
| PubMedID- 21341505 | Nonenzymatic glycation of proteins or maillard reaction is increased in diabetes mellitus due to hyperglycemia and leads to several complications such as blindness, heart disease, nerve damage and kidney failure. |
| PubMedID- 24612502 | The maximum effective dose of metformin to treat hyperglycemia in patients with type 2 diabetes is 1000 mg twice daily. |
| PubMedID- 22260979 | Although hyperglycemia associated with diabetes mellitus is well known to enhance ros production in vascular endothelial cells, the effects of either acute or chronic high glucose environments on neurons and glial cells remain unclear. |
| PubMedID- 22683753 | hyperglycemia in association with diabetes mellitus makes esrd patients resistant to hcy-lowering therapy. |
| PubMedID- 24355557 | Therefore, they are particularly sensitive to oxidative stress which may not only result from hyperglycemia associated with diabetes, but may also have an important causal role in β-cell failure and the development of insulin resistance and t2dm [21]. |
| PubMedID- 21300843 | hyperglycemia in diabetes causes abnormal carbohydrate metabolism and the production of advanced glycation end products, leading to alteration of gene expression and activities of the cellular glycosyltransferases and glycosidases (18). |
| PubMedID- 21193625 | The ada and the easd published an expert consensus statement on the approach to management of hyperglycemia in individuals with type 2 diabetes (82). |
| PubMedID- 23418497 | Both type 1 and type 2 diabetes lead to hyperglycemia that further results in a number of complications, including damage to nerves (diabetic neuropathy) [2]. |
| PubMedID- 25593844 | Standard tests for hyperglycemia in diabetes, such as fasting glucose and hemoglobin (hba1c), are currently not recommended for gdm screening. |
| PubMedID- 22745633 | hyperglycemia in individuals with diabetes mellitus usually compromises myocardial contractile function and energy metabolism independent of macro- and microvascular coronary anomalies [1–4]. |
| PubMedID- 22915920 | The accuracy of an insulin delivery system is of utmost importance in avoiding diabetes-related complications due to either hyperglycemia or hypoglycemia. |
| PubMedID- 23584372 | Type 2 diabetes consists of progressive hyperglycemia, insulin resistance, and pancreatic beta-cell failure which could result from glucose toxicity, inflammatory cytokines, and oxidative stress. |
| PubMedID- 21421802 | Over time, the hyperglycemia seen in patients with diabetes can increase the risk of both microvascular complications and result in a two- to fourfold increase in the risk of macrovascular complications (1–3). |
| PubMedID- 24465790 | Thus, hyperglycemia in diabetes enhances the formation of ages and leads to fluorescent or non-fluorescent products, sometimes creating cross-links [12]. |
| PubMedID- 24348462 | Overt diabetes mellitus – with hyperglycemia and severe insulin deficiency as prominent features – can be considered a disorder of domestication in that affected cats would die without treatment. |
| PubMedID- 26442119 | Implication of cardiovascular complications including cardiomyopathy in diabetes can be attributed to hyperlipidemia, hyperglycemia, and oxidative stress which promote atherosclerosis [24–26]. |
| PubMedID- 26301188 | According to various studies, the occurrence of various microvascular and macrovascular complications in diabetes is attributed to hyperglycemia and dysglycemia (peaks and nadirs). |
| PubMedID- 24857350 | Background: chorea is a common presenting feature of metabolic disorders, including nonketotic hyperglycemia in patients with type 2 diabetes mellitus, but rarely has been reported in diabetic ketoacidosis, hypothyroidism and vitamin b12 deficiency. |
| PubMedID- 20067962 | Type 2 diabetes constitutes a group of metabolic aberrations including hyperglycemia, inflammation, and insulin resistance that increase the risk of cardiovascular disease (1). |
| PubMedID- 20393151 | Objective: an increase in the rate of gluconeogenesis is largely responsible for the hyperglycemia in individuals with type 2 diabetes, with the antidiabetes action of metformin being thought to be achieved at least in part through suppression of gluconeogenesis. |
| PubMedID- 22842610 | Self-monitoring of blood glucose is the standard of care in management of hyperglycemia among patients with diabetes mellitus. |
| PubMedID- 26024569 | Purpose: although newer agents (dipeptidyl peptidase [dpp]-4 inhibitors and glucagon-like peptide [glp]-1 receptor agonists) are available for the treatment of hyperglycemia in patients with type 2 diabetes mellitus (t2dm), the impact of the availability of these agents on the use of second-generation sulfonylureas (sus) is unknown. |
| PubMedID- 24843412 | Clinically, the pulmonary system appears to be protected from the toxic actions of hyperglycemia because patients with type 1 diabetes are relatively free from vascular pathologies of the pulmonary system. |
| PubMedID- 20042772 | As retinopathy is estimated to take at least 5 years to develop after the onset of hyperglycemia (298), patients with type 1 diabetes should have an initial dilated and comprehensive eye examination within 5 years after the onset of diabetes. |
| PubMedID- 23264422 | As retinopathy is estimated to take at least 5 years to develop after the onset of hyperglycemia, patients with type 1 diabetes should have an initial dilated and comprehensive eye examination within 5 years after the onset of diabetes. |
| PubMedID- 26519255 | In the spontaneous non-obese diabetic (nod) mouse model, a single injection of ascs reversed hyperglycemia associated with early-onset diabetes in 78 % of nod mice, by regulation of th1-biased immune response, expansion of regulatory t cells (tregs), and reduction of inflammatory cell infiltration in the pancreas [30]. |
| PubMedID- 22829848 | Children with type 2 diabetes, maturity-onset diabetes of youth, transient hyperglycemia, and diabetes caused by chemotherapy or cystic fibrosis are excluded from the nldd and thus were not included in the study. |
| PubMedID- 21074073 | The cardiovascular safety of intensive hyperglycemia treatment in patients with type 2 diabetes, particularly with certain agents, is an open debate. |
| PubMedID- 22837924 | [3] our study set out to estimate the prevalence and correlates of postprandial hyperglycemia in patients with type 2 diabetes and also to identify patients with isolated postprandial hyperglycemia, who are presumed to have optimal glycemic control. |
| PubMedID- 22699799 | hyperglycemia occurs in patients with poorly controlled diabetes mellitus and contributes to bone resorption and increased susceptibility to bacterial infections. |
| PubMedID- 25422773 | Diabetic peripheral neuropathy (dpn) is a well-known microvascular complication of type 2 diabetes mellitus attributed to chronic hyperglycemia, and is defined as the presence of peripheral nerve dysfunction in diabetics after exclusion of other causes3–6. |
| PubMedID- 24454371 | Our study showed that fasting hyperglycemia, mostly associated with type 2 diabetes, was the only significant predictor of vascular calcifications in esrd patients. |
| PubMedID- 25927597 | In recent years, selective sglt2 inhibitors have been developed and are now in clinical use for the treatment of hyperglycemia in patients with type 2 diabetes mellitus [19]. |
| PubMedID- 20724647 | The major contributor to the lack of ego suppression and, thus, to the exaggerated postprandial hyperglycemia in diabetes seems to be an increase in gluconeogenesis (21). |
| PubMedID- 23423609 | Nonenzymatic glycation of macromolecules, especially proteins leading to their oxidation is increased in diabetes mellitus due to hyperglycemia and play an important role in associated complications of the disease. |
| PubMedID- 24339286 | Previous studies also suggested that the progression of atherosclerosis may be independently associated with long-term hyperglycemia in patients with established diabetes.19,20 the present study evaluated the usefulness of ms compared with diabetes as a prognostic concept in patients with cli treated with pta, which is an effective therapeutic method for salvaging limbs from both major and minor amputation.21,22 the results showed that ms was not associated with adverse clinical outcomes, but that diabetes had an incremental impact on minor amputations and primary patency in cli patients treated with pta during the 2-year follow-up. |
| PubMedID- 21713142 | Experimental diabetes mellitus-induced hyperglycemia produced a significant decrease in tail flick latency time. |
| PubMedID- 24904865 | A meta-analysis of 24 studies showed that depression in patients with diabetes was significantly associated with hyperglycemia in both type 1 and type 2 diabetes mellitus24). |