PedAM
Pediatric Disease Annotations & Medicines
| Disease | hyperglycemia |
| Symptom | |diabetes |
| Sentences | 382 |
| PubMedID- 22778984 | It is well established that the chronic hyperglycemia associated with diabetes directly damages the microcirculation, leading to small vessel dysfunction 5. |
| PubMedID- 24671257 | Moreover, the occurrence of peri-implantitis, bacteremia, or hyperglycemia in individuals with diabetes may be long-lasting; however, our electrochemical tests were carried out over the short term. |
| PubMedID- 23470218 | Chronic hyperglycemia in patients with diabetes is associated with a myriad of harmful complications. |
| PubMedID- 22247866 | Therefore, the aqueous and ethanolic extracts of c. grandis may have stimulated glycogenesis and / or inhibited glycogenolysis in diabetic rat liver and may prevent or be helpful in reducing the complications of lipid profile seen in some diabetes with hyperglycemia and hypercholesterolemia coexisting. |
| PubMedID- 26343954 | Enhanced oxidative stress and hyperglycemia are associated with diabetes mellitus (dm). |
| PubMedID- 21876346 | At week 16 of diabetes, rats with equivalent hyperglycemia and albuminuria were randomized into groups which received no treatment, vehicle alone or a selective jnk inhibitor (cc-930, 60 mg/kg/bid) for 10 weeks. |
| PubMedID- 22187370 | Type 1 diabetes presents clinically with overt hyperglycemia resulting from progressive immune-mediated destruction of pancreatic beta-cells and associated metabolic dysfunction. |
| PubMedID- 22915920 | The accuracy of an insulin delivery system is of utmost importance in avoiding diabetes-related complications due to either hyperglycemia or hypoglycemia. |
| PubMedID- 22128218 | It has been shown that the hyperglycemia associated with diabetes mellitus results in the activation of neutrophils(51) and that this activation contributes to an increase in oxidative stress that is partly responsible for diabetes complications. |
| PubMedID- 23452437 | These results suggest that the progression of atherosclerosis might be directly dependent upon hyperglycemia in patients with established diabetes status but might be influenced by multiple cv risk factors, especially the component of increased blood pressure , in patients with a status of ms without diabetes. |
| PubMedID- 25181406 | The aims of the study were to compare the glycemic control achieved by using sliding-scale or basal-bolus regimens for the management of severe or acute hyperglycemia in patients with type 2 diabetes and to analyze factors associated with the types of insulin therapy used in the management of severe or acute hyperglycemia. |
| PubMedID- 20435798 | Objective: hospital hyperglycemia, in individuals with and without diabetes, has been identified as a marker of poor clinical outcome in cardiac surgery patients. |
| PubMedID- 20413513 | The 11-beta-hydroxysteroid dehydrogenase type 1 inhibitor incb13739 improves hyperglycemia in patients with type 2 diabetes inadequately controlled by metformin monotherapy. |
| PubMedID- 20513244 | Chronic hyperglycemia in diabetes can lead to various complications, affecting the cns 3. |
| PubMedID- 22573917 | The chronic hyperglycemia resulting from poorly controlled diabetes can prime neutrophils and monocytes, resulting in an exaggerated inflammatory response and tissue damage. |
| PubMedID- 24717767 | Abnormal regulation of glucagon secretion has been implicated in the development of hyperglycemia in patients with type 2 diabetes mellitus , and a recent study in animal models indicated that a reduction in glucagon action can have profound effects on mitigating hyperglycemia even in the presence of severe hypoinsulinemia . |
| PubMedID- 24089511 | Glp-1 agonists have been incorporated into standard algorithms to treat hyperglycemia in patients with type 2 diabetes, and while the objective of these treatment regimens is to reduce glycemia safely (2), the importance of specifically targeting postprandial glycemia is increasingly being recognized (3). |
| PubMedID- 22010455 | The patient presented symptoms of diabetes with extreme hyperglycemia >1600 mg/dl and nonketotic hyperosmolar coma. |
| PubMedID- 19833883 | Such examples are cdk4-deficient (32,33) or cyclin d2–deficient (18,34) mice; both models have a progressive reduction of β-cell number and gross onset of diabetes with features of hyperglycemia and glucose intolerance. |
| PubMedID- 21838680 | The increased oxidative stress in subjects with type 2 diabetes is a consequence of several abnormalities, including hyperglycemia, insulin resistance, hyperinsulinemia, and dyslipidemia, each of which contributes to mitochondrial superoxide overproduction in endothelial cells of large and small vessels as well as the myocardium. |
| PubMedID- 22071577 | diabetes mellitus, a state of persistent hyperglycemia, is a major cause of micro- and macrovascular diseases. |
| PubMedID- 21172030 | Agents that modulate bile acids may potentially affect both cholesterol and glucose metabolism, and hence dyslipidemia and hyperglycemia, in patients with type 2 diabetes . |
| PubMedID- 26317347 | Agonist-induced activation of pparγ has been demonstrated to increase insulin sensitivity and thiazolidinediones (tzd) are used clinically to reduce insulin resistance and hyperglycemia in patients with type 2 diabetes, although these drugs are also associated with weight gain . |
| PubMedID- 23009606 | Regarding the mechanism involved in this association, it seems that prolonged hyperglycemia associated with diabetes causes the formation of advanced glycation end-products (age). |
| PubMedID- 24808678 | 5 complications due to hyperglycemia in diabetes mellitus can be prevented by using rational use of oral antidiabetic drugs (oads) and insulin. |
| PubMedID- 23522691 | Depression is associated with hyperglycemia in diabetes, which in turn, increases the risk of diabetic complications such as retinopathy, neuropathy and nephropathy . |
| PubMedID- 24516103 | Dipeptidyl peptidase-4 inhibitors prevent the degradation of incretin hormones and reduce postprandial hyperglycemia in patients with type 2 diabetes mellitus. |
| PubMedID- 23961474 | religious requirements, which mandate practices like fasting etc., plays a role in limiting patients’ ability to comply with medical advice on proper diabetes care leading to hyperglycemia, diabetic ketoacidosis, dehydration and thrombosis. |
| PubMedID- 23657005 | There may be evidence to clarify why unabsorbable carbohydrates improve postprandial hyperglycemia in diabetes patients 3, which is also the mechanism that explains the effects of tgd. |
| PubMedID- 24194733 | In diabetes, reduction of endothelial no-levels, systemic hyperglycemia if uncontrolled, generation of reactive oxygen species, oxidative stress, and increased ldl-oxidation, formation of ages, and increased circulating free fatty acids are factors that add to atherosclerosis and cvd risk. |
| PubMedID- 26141922 | hyperglycemia in diabetes mellitus causes glycation of membrane enzymes along with oxidative stress leading to decrease in activity of na+/k+-atpase and other changes in erythrocyte membranes 1. |
| PubMedID- 22355231 | Long standing diabetes with uncontrolled hyperglycemia is known to cause increased nonenzymatic glycation of proteins. |
| PubMedID- 22615627 | Antioxidant activity of rhus coriaria could also be useful for prevention of diabetes complications due to hyperglycemia (11)figure 1. |
| PubMedID- 23882045 | The importance of avoiding prolonged hyperglycemia in patients with short diabetes duration in order to minimize its negative effect on late microvascular and macrovascular complications has been established (11). |
| PubMedID- 20484139 | Elevated hgp caused by defective suppression of gluconeogenesis is one of the primary defects contributing to fasting hyperglycemia in patients with type 2 diabetes (2–4). |
| PubMedID- 26301188 | According to various studies, the occurrence of various microvascular and macrovascular complications in diabetes is attributed to hyperglycemia and dysglycemia (peaks and nadirs). |
| PubMedID- 23415113 | Dapagliflozin, a highly selective inhibitor of sglt2, has demonstrated efficacy, alone or in combination with metformin, in reducing hyperglycemia in patients with type 2 diabetes . |
| PubMedID- 25456647 | Sglt2 inhibition offers a novel mechanism to mitigate hyperglycemia in patients with diabetes and the introduction of sglt2 has added a significant new tool to the antihyperglycemic armamentarium. |
| PubMedID- 20959527 | Atrial natriuretic peptide (anp) levels correlate with hyperglycemia in diabetes mellitus, but anp effects on pancreatic islet beta-cell insulin secretion are controversial. |
| PubMedID- 24843469 | Chronic hyperglycemia in diabetes can therefore induce persistent er stress, cause β‐cell dysfunction and finally lead to a reduction in β‐cell mass through apoptosis1. |
| PubMedID- 22649411 | In hyperglycemia, as with diabetes mellitus and metabolic syndrome, high activity of the krebs cycle due to high substrate availability may increase the h+ gradient over the mitochondrial membrane (figure 2a), leading to inhibition of enzymatic steps mediated by complexes within the electron transport chain, including succinate dehydrogenase (complex ii; figure 2a; brownlee, 2005). |
| PubMedID- 22142413 | Furthermore, the formation of ages may play a key role in diabetes and cvd, leading to chronic hyperglycemia, dyslipidemia and oxidative stress 5. |
| PubMedID- 24790595 | Of great clinical interest, synthetic ligands of pparγ, belonging to the class of thiazolidinediones (tzds), such as troglitazone, pioglitazone, and rosiglitazone, function as insulin sensitizers and are used for treating hyperglycemia in patients with type 2 diabetes . |
| PubMedID- 25562721 | Cedrela odorata is effective in diminishing glucose levels in vitro and in vivo and in ameliorating oxidative damage that occurs in diabetes and/or due to hyperglycemia in rats. |
| PubMedID- 23565389 | Despite an increasing number of therapeutic options, optimal management of hyperglycemia in patients with type 2 diabetes (t2d) remains an elusive goal for a majority of patients. |
| PubMedID- 20046232 | The vascular and systemic complications in diabetes are associated with hyperglycemia-induced overproduction of reactive oxygen species 8,9. |
| PubMedID- 23573479 | Male kk/ta mice spontaneously exhibit type 2 diabetes associated with hyperglycemia, glucose intolerance, hyperinsulinemia, mild obesity and microalbuminuria, conditions which are more severe than those found in the female (2-4). |
| PubMedID- 23791753 | Chronic hyperglycemia in diabetes is associated with oxidative stress mediated tissue damage. |
| PubMedID- 20876728 | The systemic metabolic disturbances of diabetes, including hyperglycemia and hyperlipidemia, likely play a central role in the pathogenesis of diabetes-associated atherosclerosis through the generation of oxidative stress. |
| PubMedID- 23506302 | The modifications induced by maternal diabetes may be attributed to hyperglycemia and fetal hyperinsulinemia, which affect lipid and protein synthesis . |