PedAM
Pediatric Disease Annotations & Medicines
| Disease | hyperglycemia |
| Symptom | |diabetes |
| Sentences | 382 |
| PubMedID- 25767499 | Moreover, hyperglycemia in diabetes mellitus can induce hippocampal blood capillary injury, leading to regional ischemia and elevated bad expression levels. |
| PubMedID- 23099862 | Furthermore, experimental suppression of hyperglucagonemia corrects postprandial hyperglycemia in individuals with type 2 diabetes (7). |
| PubMedID- 22489155 | diabetes mellitus patients with long-term hyperglycemia produce more ofr due to increased glucose autoxidation and protein saccharification, which weakens oxidation resistance and initiates oxidation stress . |
| PubMedID- 23826312 | Uncontrolled or poorly regulated hyperglycemia in diabetes causes serious metabolic dysregulation, including hyperlipidemia, hypercholesterolemia, ketosis, impaired liver function, liver damage, weight loss, and development of cataracts. |
| PubMedID- 22701470 | The direct impact of hyperglycemia-induced vasodilation in patients with type 1 diabetes is not certain. |
| PubMedID- 24612502 | The maximum effective dose of metformin to treat hyperglycemia in patients with type 2 diabetes is 1000 mg twice daily. |
| PubMedID- 21617178 | Because of a mutation in the leptin receptor, bks db/db mice are hyperphagic and obese, develop severe type 2 diabetes with marked hyperglycemia, and serve as an experimental model of type 2 diabetes. |
| PubMedID- 20427697 | In fact, a number of previous studies have demonstrated that lowering hyperglycemia in patients with type 2 diabetes can also lead to marked improvements of insulin secretion in response to intravenous glucose and other secretagogues, probably mediated by the mechanism of β-cell rest (71–73). |
| PubMedID- 22585309 | Beyond hyperglycemia in diabetes: role of statin treatment on thrombogenesis triggered by inflammation: editorial to: "impact of statins on the coagulation status of type 2 diabetes patients evaluated by a novel thrombin-generations assay" by p. |
| PubMedID- 23423609 | Nonenzymatic glycation of macromolecules, especially proteins leading to their oxidation is increased in diabetes mellitus due to hyperglycemia and play an important role in associated complications of the disease. |
| PubMedID- 20923484 | In women, postprandial hyperglycemia was associated with shorter diabetes duration and higher preprandial blood glucose concentration, whereas postprandial hypoglycemia was associated with higher physical activity. |
| PubMedID- 25596527 | Glut4 function is impaired in obesity and type 2 diabetes leading to hyperglycemia and an increased risk of cardiovascular disease and neuropathy. |
| PubMedID- 21525446 | diabetes is associated with hyperglycemia-specific microvascular complications. |
| PubMedID- 24224091 | Several factors such as dyslipidemia or hyperlipidemia which are involved in the microvascular and macrovascular complications as well as hyperglycemia are associated with the diabetes disease which is the major cause of morbidity and death 4. |
| PubMedID- 21220752 | Conclusion: we conclude that hyperglycemia in diabetes, independent of plasma aldosterone concentration, induces podocyte injury through mr-mediated ros production and leads to proteinuria. |
| PubMedID- 21286019 | Glucocorticoids not only exacerbate hyperglycemia in patients with known diabetes mellitus (dm), but also cause dm in patients without documented hyperglycemia before the initiation of glucocorticoid therapy (2). |
| PubMedID- 23826343 | These in vitro results support out findings in vivo and further imply that hyperglycemia associated with diabetes leads to elevation in erbb2 expression and activity that ultimately mediates vascular dysfunction. |
| PubMedID- 25961051 | hyperglycemia is common in patients with diabetes in hospital and several guidelines have suggested using basal and prandial subcutaneous (s.c.) insulin in non-critically ill patients as first-choice pharmacological treatment to ensure the best possible glycemic control, combined with an appropriate nutrition scheme . |
| PubMedID- 24495364 | Background: type 2 diabetes along with chronic hyperglycemia may result in cognitive impairment. |
| PubMedID- 21085649 | However, newer data reveal that hyperketonemia or diabetic ketoacidosis can also co-exist with hyperglycemia in patients with type 2 diabetes . |
| PubMedID- 22474580 | Thus, hyperglycemia associated with diabetes may alter the normal regulation of bone and lead to increased adiposity resulting in compromised bone quality. |
| PubMedID- 20668682 | The gk rats are a model of type ii diabetes that presents with hyperglycemia but without severe hyperlipidemia. |
| PubMedID- 26024569 | Purpose: although newer agents (dipeptidyl peptidase dpp-4 inhibitors and glucagon-like peptide glp-1 receptor agonists) are available for the treatment of hyperglycemia in patients with type 2 diabetes mellitus (t2dm), the impact of the availability of these agents on the use of second-generation sulfonylureas (sus) is unknown. |
| PubMedID- 21139669 | It is highly probable that the hyperglycemia in diabetes leads to an array of metabolic changes, many of which may be directed toward limitation or repair of the damage. |
| PubMedID- 21792376 | hyperglycemia resulting from diabetes has an adverse impact on embryonic development through induction of apoptosis in mice embryonic tissues . |
| PubMedID- 25705228 | To prevent worsening hyperglycemia with underlying diabetes mellitus, steroids were avoided and the patient was started on an immunosuppressant, azathioprine. |
| PubMedID- 25352436 | In response to hyperglycemia in patients with diabetes, many signaling pathways contribute to the pathogenesis of diabetic complications, including diabetic retinopathy (dr). |
| PubMedID- 24348460 | On the other hand, were unable to relate polymorphisms of pyruvate dehydrogenase kinase four gene, a mitochondrial kinase attributing to hyperglycemia, with mets or diabetes in korean (49). |
| PubMedID- 22055501 | The role of hyperglycemia in cad associated with type 2 diabetes is less clear. |
| PubMedID- 24379274 | It has also been found that serum vap-1 was elevated in acute and chronic hyperglycemia and in patients with diabetes as well as in chronic kidney disease. |
| PubMedID- 24250559 | Uncontrolled chronic hyperglycemia in diabetes leads to severe complications including neuropathy, retinopathy, and autonomic dysfunctions. |
| PubMedID- 20978101 | Noninvasive assessment of exercise-related intramyocellular acetylcarnitine in euglycemia and hyperglycemia in patients with type 1 diabetes using (1)h magnetic resonance spectroscopy: a randomized single-blind crossover study. |
| PubMedID- 24864247 | hyperglycemia in diabetes can cause up to a 4-fold increase in neuronal glucose levels. |
| PubMedID- 24387617 | An early work reveals that hyperglycemia in diabetes triggers nutrient excess in neurons, that mediates the phenotype changes in mitochondria, and the development of axon loss in sensory neuropathy is linked to this nutrient excess . |
| PubMedID- 23880900 | When starting bedtime insulin in type 2 diabetes patients, those with fasting type hyperglycemia are prone to greater weight gain. |
| PubMedID- 25849026 | hyperglycemia in diabetes stimulates the increase in tgfβ-1 expression and, in turn, induces kidney multi-cellular hypertrophy through autocrine and paracrine pathways. |
| PubMedID- 25317173 | Early macrovascular atherosclerosis may play a crucial role in subtle brain atrophy in type 2 diabetes mellitus patients, with chronic hyperglycemia playing a lesser role. |
| PubMedID- 21470936 | Whether or not the elevated risk is moderated by the degree of control of the hyperglycemia associated with diabetes will need to be determined in future studies. |
| PubMedID- 23785354 | diabetes showing hyperglycemia, oxidative stress, and hyperhomocysteinemia deteriorates bone material properties in terms of collagen post-translational modification such as enzymatic immature and mature cross-links and non-enzymatic ages formation. |
| PubMedID- 23734259 | Metabolic stress, such as chronic hyperglycemia in diabetes, is known to increase the production of reacting oxygen species (ros) and promote inflammatory gene expression, accelerating vascular aging 1. |
| PubMedID- 26001054 | Studies have demonstrated that an episode of transient hyperglycemia in diabetes can induce epigenetic changes that result in lasting changes in gene expression, i.e. |
| PubMedID- 23620811 | Here, we provide novel evidence that chronic aicar-induced ampk activation in vivo did not reduce hyperglycemia in rats with stz-induced diabetes, although it enhanced glycogen accumulation and fatty acid oxidation in white muscles and potently reduced circulating nefa and tg levels in these animals. |
| PubMedID- 21193630 | Unexplained hyperglycemia in a patient with type 1 diabetes may suggest impending dka, and monitoring of ketones should therefore be performed. |
| PubMedID- 24151186 | hyperglycemia in diabetes enhances the accumulation of ages in the np and triggers disc degeneration. |
| PubMedID- 24465132 | When contraindications to its use exist or patients cannot tolerate it due to adverse effects, clinicians have a variety of other classes of agents to treat hyperglycemia associated with type 2 diabetes mellitus. |
| PubMedID- 22844269 | Prolonged exposure to chronic hyperglycemia in diabetes can lead to various complications affecting the cardiovascular, renal, neurological, and visual systems 2. |
| PubMedID- 25812084 | Metformin is a drug used to decrease hyperglycemia in patients with type-2 diabetes, in part by activating ampk and is currently under investigation as a potential treatment for several types of cancer . |
| PubMedID- 23448719 | Persistent hyperglycemia in diabetes can result in sustained levels of neuronal glucose up to fourfold in healthy individuals and lead to glucose neurotoxicity.46 it is therefore tempting to speculate that the lower systemic glycemia and significantly improved ability to respond to glucose challenge in ω-3pufa-fed animals may contribute, in part, to the protective effects of ω-3pufas on neuronal function. |
| PubMedID- 24455476 | diabetes is associated with hyperglycemia and this has been shown to have a direct effect on mitochondrial function . |
| PubMedID- 22590838 | Perioperative hyperglycemia is common in patients with type 2 diabetes undergoing coronary artery bypass graft (cabg) surgery and there is a direct relation between postoperative hyperglycemia and mortality rate in these patients. |