eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | narcolepsy |
| Symptom | |cataplexy |
| Sentences | 170 |
| PubMedID- 24503475 | Sympathetic and cardiovascular changes during sleep in narcolepsy with cataplexy patients. |
| PubMedID- 24363104 | narcolepsy with cataplexy is a neurological disorder regarded as a disease model for the selective hypocretin system damage, and also shares several psychopatological traits and comorbidities with psychiatric disorders. |
| PubMedID- 20022299 | Rbd was idiopathic in 11 patients (1.6%; 9 men) and symptomatic in 23 patients (3.3%; 18 men) secondary to parkinsonian syndromes (n=11), use of antidepressants (n=7), narcolepsy with cataplexy (n=4), and pontine infarction (n=1). |
| PubMedID- 21658163 | Background and purpose: the second version of the international classification of sleep disorders suggests narcolepsy with cataplexy can be diagnosed on history alone. |
| PubMedID- 24882899 | The proportions for narcolepsy with and without cataplexy were 0.07% (95% ci: 0.02-0.37%) and 0.20% (95% ci: 0.07-0.58%), respectively. |
| PubMedID- 21966067 | Localized cortical thinning in narcolepsy patients with cataplexy was found in orbitofrontal gyri, dorsolateral and medial prefrontal cortexes, insula, cingulate gyri, middle and inferior temporal gyri, and inferior parietal lobule of the right and left hemispheres at the level of a false discovery rate p<0.05. |
| PubMedID- 22309460 | The sleep-wake disorder narcolepsy with cataplexy is associated with the loss of hypocretin-(orexin-) producing neurons in the lateral hypothalamus. |
| PubMedID- 23772198 | narcolepsy with cataplexy associated with sleep-related rhythmic movements. |
| PubMedID- 24376396 | narcolepsy with cataplexy is associated with severe daytime sleepiness (tafti et al., 2005) due to the complete disorganization of the sleep/wake cycle, with sudden onset of rapid eye movement (rem) sleep and cataplexy (loss of skeletal muscle tone without the loss of consciousness triggered by emotions). |
| PubMedID- 24784789 | Background: the association between narcolepsy with cataplexy and the hypocretinergic system in the central nervous system is strong since up to 75-90% of all patients have cerebrospinal fluid (csf) hypocretin-1 deficiency. |
| PubMedID- 20927145 | According to the new classification, the multiple sleep latency test (mslt) is mandatory for diagnosing narcolepsy without cataplexy, and advisable for diagnosing narcolepsy with cataplexy. |
| PubMedID- 21655207 | Other important differential diagnosis include narcolepsy with and without cataplexy, idiopathic hypersomnia with and without long sleep time, recurrent hypersomnia, behaviorally induced insufficient sleep syndrome, hypersomnia due to medical condition, hypersomnia due to drug or substance, hypersomnia not due to a substance or known physiologic condition, and also sleep-related disordered breathing and periodic leg movement disorders. |
| PubMedID- 24635684 | narcolepsy with cataplexy is a complex sleep disorder that affects the modulation of emotions: cataplexy, the key symptom of narcolepsy, is indeed strongly linked with emotions that usually trigger the episodes. |
| PubMedID- 24470783 | As is the case in narcolepsy with cataplexy, an autoimmune mechanism has been suggested; however, the evidence is much less robust in kleine-levin syndrome. |
| PubMedID- 24533004 | The usual age at onset of narcolepsy with cataplexy is in the second or third decade. |
| PubMedID- 24297328 | Disruption of the hypocretin system leads to narcolepsy with cataplexy in humans as well as in animal models (chemelli et al. |
| PubMedID- 22558075 | Background: narcolepsy with cataplexy (nc) is a disabling sleep disorder characterized by early loss of hypocretin neurons that project to areas involved in the attention network. |
| PubMedID- 23827430 | narcolepsy with cataplexy is also rare in children younger than 5 years of age. |
| PubMedID- 23946710 | Methods: eight male, medication free, hypocretin deficient, narcolepsy with cataplexy patients, and 8 healthy controls matched for age, sex, body mass index (bmi), waisttohip ratio, and body fat percentage were assessed. |
| PubMedID- 23739971 | narcolepsy with cataplexy is caused by a loss of orexin (also known as hypocretin) signaling, but almost nothing is known about the neural mechanisms through which positive emotions trigger cataplexy. |
| PubMedID- 23036267 | Results: the 139 patients (45% men) aged 36+/-15years (range: 9-74) suffered narcolepsy (n=94, 66% with cataplexy), idiopathic (n=37) and symptomatic hypersomnia (n=8) refractory to modafinil, methylphenidate and sodium oxybate. |
| PubMedID- 22470463 | The incidence is estimated to be 0.74 per 100 000 person-years for narcolepsy with cataplexy and 1.37 per 100 000 person-years for narcolepsy with or without cataplexy 2. |
| PubMedID- 21679260 | An effect of birth month on the occurrence of narcolepsy with cataplexy was not found in a study of 307 cases after adjusting for changing birth patterns in the general population. |
| PubMedID- 25142559 | The aim is to address the involvement of mirnas in the pathophysiology of central hypersomnias including autoimmune narcolepsy with cataplexy and hypocretin deficiency (type 1 narcolepsy), narcolepsy without cataplexy (type 2 narcolepsy), and idiopathic hypersomnia. |
| PubMedID- 20403960 | Human narcolepsy with cataplexy is a neurological disorder, which develops due to a deficiency in hypocretin producing neurons in the hypothalamus. |
| PubMedID- 23649748 | This diagnosis was defined as narcolepsy associated with cataplexy plus hla-dqb1*06:02 positivity (no cerebrospinal fluid hypocretin-1 results available) or narcolepsy with documented low ( |
| PubMedID- 24468101 | Objectives: we aimed to compare post-pandemrix vaccination (postvaccine) childhood narcolepsy with cataplexy (nc) vs. |
| PubMedID- 21920673 | Recent results: antidepressants have long been used in control of narcolepsy with cataplexy, but their sustained efficacy in this role has been in question. |
| PubMedID- 22171205 | Study objectives: the possible relationship between cerebrospinal fluid (csf) hypocretin and leptin levels, overweight, and association to risk factors for diabetes 2 in narcolepsy with cataplexy were compared to patients with idiopathic hypersomnia and controls. |
| PubMedID- 20576035 | As disruption of orexin (hypocretin) signaling is a primary defect in narcolepsy with cataplexy, we investigated whether markers of cholinergic synaptic transmission might be altered in mice constitutively lacking orexin receptors (double receptor knockout; dko). |
| PubMedID- 23646285 | Hla-dqb1*06:02-positive ehs and narcolepsy with cataplexy are associated with the same susceptibility genes. |
| PubMedID- 25271675 | narcolepsy with cataplexy patients experienced significantly more sleep-wake transitions during night than did narcolepsy without cataplexy patients (p = 0.0199) and healthy subjects (p = 0.0265). |
| PubMedID- 24656461 | Conclusion: the diagnosis of narcolepsy with cataplexy at onset can be challenging in young children. |
| PubMedID- 23674942 | In one report, clonazepam was shown to improve cataplexy in 10 of 14 patients with narcolepsy although no improvement in daytime sleepiness was reported. |
| PubMedID- 22973425 | Central hypersomnias includes narcolepsy with and without cataplexy, recurrent hypersomnia, idiopathic hypersomnia, with and without long sleep time, behaviorally induced insufficient sleep syndrome, hypersomnia and narcolepsy due to medical conditions, and finally hypersomnia induced by substance intake. |
| PubMedID- 21570344 | Background: narcolepsy with cataplexy (nc) is caused by the loss of hypocretin neurons. |
| PubMedID- 23772196 | narcolepsy with cataplexy mimicry: the strange case of two sisters. |
| PubMedID- 20810310 | Injurious rem sleep behaviour disorder in narcolepsy with cataplexy contributing to criminal proceedings and divorce. |
| PubMedID- 20525256 | cataplexy, with or without narcolepsy, typically laughter-induced, is another common symptom. |
| PubMedID- 24268496 | Our case-control study aimed to compare clinical differences and analyze risk factors in children who developed narcolepsy with cataplexy (n-c), schizophrenia, and n-c followed by schizophrenia. |
| PubMedID- 25750784 | However, because the sample size of narcolepsy with cataplexy was small, no analyses comparing classification accuracy for those with or without cataplexy were reported here. |
| PubMedID- 21633708 | Background: narcolepsy with cataplexy (nc) is currently thought to be an autoimmune-mediated disorder in which environmental risk factors make a significant contribution to its development. |
| PubMedID- 24048081 | Purpose of review: a number of european countries have reported a dramatic increase in the rates of childhood narcolepsy with cataplexy in children immunized with a split-virion adjuvanted swine flu vaccine. |
| PubMedID- 23802043 | narcolepsy with cataplexy is perhaps the best investigated among these. |
| PubMedID- 22406786 | We present a case of narcolepsy with cataplexy with classical clinical and polysomnographic findings of narcolepsy. |
| PubMedID- 23616586 | This control is profoundly impaired in narcolepsy with cataplexy, a disease resulting from the loss of orexin/hypocretin neurotransmitter signalling in the brain. |
| PubMedID- 25286384 | Orexins are bioactive peptides, which have been shown to play a pivotal role in vigilance state transitions: the loss of orexin-producing neurons (orexin neurons) leads to narcolepsy with cataplexy in the human. |
| PubMedID- 20373351 | narcolepsy with cataplexy is a sleep-wake disorder caused by a loss of hypothalamic hypocretins. |
| PubMedID- 24574957 | Importantly, patients suffering from narcolepsy with cataplexy, a condition associated with a disrupted ox/hcrt system, experience a higher frequency of pain (dauvilliers et al., 2011). |
| PubMedID- 23385692 | Breakdown in this circuitry both results in and explains the manifestations of a variety of sleep disorders including insomnia, narcolepsy with cataplexy, and rem sleep behavior disorder. |