eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | narcolepsy |
| Symptom | |cataplexy |
| Sentences | 170 |
| PubMedID- 23372264 | Study objectives: we analyzed the potential predictive factors for precocious puberty, observed in some cases of childhood narcolepsy with cataplexy (nc) and for obesity, a much more common feature of nc, through a systematic assessment of pubertal staging, body mass index (bmi), and metabolic/endocrine biochemical analyses. |
| PubMedID- 23997366 | Objective: to investigate the effect of psychostimulants on impulsivity, depressive symptoms, addiction, pathological gambling, and risk-taking using objective sensitivity tests in narcolepsy with cataplexy (nc). |
| PubMedID- 23444425 | Results: case notes for 245 children and young people were reviewed; 75 had narcolepsy (56 with cataplexy) and onset after 1 january 2008. |
| PubMedID- 24994458 | Nine healthy controls and twenty-one narcolepsy patients with cataplexy were studied. |
| PubMedID- 22505866 | This report describes a case of narcolepsy with cataplexy masked by the chronic use of cigarettes and nicotine patches. |
| PubMedID- 26418536 | Nevertheless, in our study, no difference in the prevalence of migraine was found between narcolepsy patients with cataplexy and those without cataplexy or between idiopathic hypersomnia patients with long sleep time and those without long sleep time. |
| PubMedID- 23616702 | Methylphenidate and dextroamphetamine are approved in this indication, although these medications have the potential for abuse and their use should therefore be monitored closely.50 sodium oxybate has been shown to significantly reduce es and cataplexy in patients with narcolepsy in randomized clinical trials and it is the only fda-approved medication for the treatment of both of these symptoms.51–54 modafinil and armodafinil have been shown to address es in patients with narcolepsy in randomized controlled trials55–57 and are approved by the fda for this indication. |
| PubMedID- 24391530 | The orexin system plays a particularly important role in the normal expression of waking and sleep since its disruption underlies the sleep disorder narcolepsy with cataplexy in humans (peyron et al., 2000; thannickal et al., 2000) and produces a narcolepsy phenotype with unstable behavioral states, sleep attacks and cataplexy-like motor arrests in animals (chemelli et al., 1999; lin et al., 1999; hara et al., 2001; willie et al., 2003; beuckmann et al., 2004; mochizuki et al., 2004; kalogiannis et al., 2011). |
| PubMedID- 21234339 | In fact, a medline search yielded over 30 cases of secondary narcolepsy without cataplexy during the last 50 years, but yielded only 13 cases with secondary cataplexy. |
| PubMedID- 20469811 | Study objectives: to investigate the occurrence of restless legs syndrome (rls) in narcolepsy with cataplexy (nc). |
| PubMedID- 24650212 | narcolepsy with cataplexy is caused by a deficiency in the production of hypocretin/orexin, which regulates sleep and wakefulness, and also influences appetite, neuroendocrine functions and metabolism. |
| PubMedID- 24381371 | To replicate and/or extend these findings, we have tested hla-dqb1, the previously identified 5 variants, and 10 other potential variants in a large european sample of narcolepsy with cataplexy subjects. |
| PubMedID- 24340297 | narcolepsy with cataplexy is rare in children under 5 years of age. |
| PubMedID- 20181520 | Objective: to test the autonomic control of cardiovascular reflexes and heart rate variability (hrv) at rest and during orthostatic stress in narcolepsy with cataplexy (nc). |
| PubMedID- 24645699 | There are no reports on the association between sporadic or familial narcolepsy with cataplexy and other non-neurological immune-mediated diseases. |
| PubMedID- 21170044 | Growing evidence supports the hypothesis that narcolepsy with cataplexy is an autoimmune disease. |
| PubMedID- 23452773 | narcolepsy (with or without cataplexy), idiopathic hypersomnia (with or without long sleep duration) and kleine - levin syndrome are the main central rare hypersomnias. |
| PubMedID- 20131387 | narcolepsy with cataplexy associated with holoprosencephaly misdiagnosed as epileptic drop attacks. |
| PubMedID- 26392230 | Each patient was diagnosed as one of the following four categories: (1) narcolepsy with cataplexy (n + c; n = 29); (2) narcolepsy without cataplexy (n - c; n = 22); (3) idiopathic hypersomnia (ih; n = 24); and (4) subjective hypersomnolence (sh; n = 33) with mean sleep latency >8 min. |
| PubMedID- 24825961 | Patients predisposed to rbd and later parkinsonism might be susceptible to a variety of triggers that, in our patient, might have been represented by a possible latent autoimmune process leading to the development of narcolepsy with cataplexy and rheumatoid arthritis, later. |
| PubMedID- 24406723 | narcolepsy with cataplexy is a sleep dysregulation disorder with alterations of rem sleep, i.e., sleep onset rem periods and rem sleep instability. |
| PubMedID- 24844961 | Methods: a total of 1 223 narcoleptic patients (nc, narcolepsy with typical cataplexy, n = 1 132; nwc, narcolepsy without cataplexy, n = 91) diagnosed at sleep center of peking university people's hospital from august 1998 to july 2011 were recruited into this retrospective study. |
| PubMedID- 25728441 | narcolepsy with cataplexy is caused by hypocretin deficiency owing to destruction of most of the hypocretin-producing neurons in the hypothalamus. |
| PubMedID- 23326757 | narcolepsy with cataplexy is characterized by loss of hypocretin-containing cells in the lateral hypothalamus. |
| PubMedID- 24575043 | Patients that suffer from narcolepsy with cataplexy have very low levels of hcrt-1 in their csf (nishino et al., 2000; peyron et al., 2000; thannickal et al., 2000). |
| PubMedID- 24033681 | narcolepsy with cataplexy (nc) is a lifelong disorder caused by loss of hypothalamic hypocretin/orexin (hcrt) neurones, often starting in childhood. |
| PubMedID- 23026503 | Objective: to investigate in narcolepsy with cataplexy (nc) patients of working age (18-65 years) the influence of age at onset, age at diagnosis and clinical features on socio-occupational conditions, disease-related economic burden, and quality of life. |
| PubMedID- 25277311 | narcolepsy with cataplexy is a sleep disorder caused by the loss of hypocretin-producing neurons in the hypothalamus. |
| PubMedID- 25325462 | Dqb1 locus alone explains most of the risk and protection in narcolepsy with cataplexy in europe. |
| PubMedID- 22470453 | Our finding is supported by the recent results from sweden, where a cohort study covering the entire population reported an almost 7-fold incidence of narcolepsy with cataplexy in children vaccinated with pandemrix compared to those in the same age group who were not vaccinated 4. |
| PubMedID- 21210337 | Background: narcolepsy with cataplexy (nc) is caused by substantial loss of hypocretin neurons. |
| PubMedID- 21713070 | Additionally, it has recently been shown that orexin-a, primarily deficient in narcolepsy with cataplexy, modulates pupil size (schreyer et al., 2009) and maybe a marker of hypocretin deficiency rather than a measure of alertness alone in narcolepsy with cataplexy (plazzi et al., 2011). |
| PubMedID- 23939463 | Importance: idiopathic narcolepsy with cataplexy is thought to be an autoimmune disorder targeting hypothalamic hypocretin neurons. |
| PubMedID- 20833530 | We report the management of a morbidly obese parturient suffering from narcolepsy with cataplexy who presented for caesarean section. |
| PubMedID- 23521426 | Introduction: narcolepsy with cataplexy is a rare disabling sleep disorder characterized by two major symptoms: excessive daytime sleepiness and cataplexy characterized by a sudden bilateral loss of voluntary muscular tone triggered by strong positive emotional factors. |
| PubMedID- 20540992 | Orexin (orx or hypocretin) is critically important for maintaining wakefulness, since in its absence, narcolepsy with cataplexy occurs. |
| PubMedID- 21966068 | narcolepsy with cataplexy associated with nocturnal compulsive behaviors: a case-control study. |
| PubMedID- 22937359 | Isolated cataplexy without associated narcolepsy has been reported with genetic associations . |
| PubMedID- 20513636 | Our results show for the first time that narcolepsy without cataplexy, where the majority of cases have normal csf hypocretin levels, is associated with olfactory dysfunction. |
| PubMedID- 25600782 | Pain perception in narcolepsy with cataplexy patients. |
| PubMedID- 22942503 | Patients: narcolepsy without cataplexy (n = 171) and control patients (n = 170), all with available csf hypocretin-1. |
| PubMedID- 20451031 | narcolepsy with cataplexy is a rare but life-long and challenging disorder. |
| PubMedID- 24293310 | Childhood narcolepsy with cataplexy represents a risk factor for subtle and heterogeneous cognitive impairments potentially resulting in academic failure, despite the normal iq. |
| PubMedID- 24796285 | Our main goal was to study different types of oneiric activity in narcolepsy with cataplexy (nc) and narcolepsy without cataplexy (n). |
| PubMedID- 23773727 | Conclusion: the data collected during 3 years following vaccination showed a significantly increased risk for narcolepsy with cataplexy (p<.0001) and reduced csf hypocretin levels in vaccinated children ages 4-19 years the first year after pandemrix(r) vaccination, with a minimum incidence of 10 of 100,000 individuals per year. |
| PubMedID- 24701532 | There are two distinct subgroups of narcolepsy: narcolepsy with cataplexy and narcolepsy without cataplexy. |
| PubMedID- 26483904 | Introduction: this paper describes narcolepsy with cataplexy in two monozygotic twin sisters. |
| PubMedID- 22055895 | Objectives: gamma-hydroxybutyrate (ghb) is currently authorized by the european medicines agency (ema) to treat narcolepsy with cataplexy in adults, and by the food and drug administration (fda) to treat cataplexy in patients with narcolepsy, with an expanded indication for the treatment of excessive daytime sleepiness. |
| PubMedID- 22841884 | narcolepsy with cataplexy is caused by a selective loss of hypocretin-producing neurons, but symptomatic narcolepsy can also result from hypothalamic and brainstem lesions caused by multiple sclerosis (ms). |
| PubMedID- 20862344 | Excessive daytime sleepiness (hypersomnia) is related to changes either in nrem (idiopathic hypersomnia), rem sleep (narcolepsy without cataplexy) or could be central in origin (narcolepsy with cataplexy). |