PedAM
Pediatric Disease Annotations & Medicines
| Disease | narcolepsy |
| Symptom | C0007384|cataplexy |
| Sentences | 180 |
| PubMedID- 26483904 | narcolepsy with cataplexy in monozygotic twins. |
| PubMedID- 20854137 | Hypocretin deficiency in narcolepsy with cataplexy is associated with a normal body core temperature modulation. |
| PubMedID- 21930661 | Additionally, the history of tonsillectomy occurring before narcolepsy with cataplexy symptom onset, and biochemical data pertaining to streptococcal infections (anti-streptolysin o titres) were also collected. |
| PubMedID- 21677900 | Measurements and results: there was no difference in risk-taking behavior between narcolepsy with or without cataplexy and the control group, as measured using the bart and the array of questionnaires. |
| PubMedID- 23950869 | Our findings , are supported by studies from sweden and u.k., which reported significant increase in the incidence of narcolepsy with cataplexy in children vaccinated with pandemrix as compared to those in the same age group who were not vaccinated , , . |
| PubMedID- 21387813 | Conclusions: neurophysiological procedures (mslt) and biological markers are necessary in the diagnosis of narcolepsy with cataplexy and hypersomnia without cataplexy. |
| PubMedID- 24656461 | Conclusion: the diagnosis of narcolepsy with cataplexy at onset can be challenging in young children. |
| PubMedID- 24503475 | We aimed to characterize autonomic changes during sleep in narcolepsy with cataplexy (nc) patients to clarify the nature of soremp events and the effect of hypocretin deficiency on sympathetic activity during sleep. |
| PubMedID- 25142559 | The aim is to address the involvement of mirnas in the pathophysiology of central hypersomnias including autoimmune narcolepsy with cataplexy and hypocretin deficiency (type 1 narcolepsy), narcolepsy without cataplexy (type 2 narcolepsy), and idiopathic hypersomnia. |
| PubMedID- 25264897 | Main outcome measures: confirmed narcolepsy with or without cataplexy with onset of excessive daytime sleepiness between january 1st, 2009, and december 31st, 2010. |
| PubMedID- 24533004 | The usual age at onset of narcolepsy with cataplexy is in the second or third decade. |
| PubMedID- 22259780 | In addition, differences in the frequencies of all other alleles except drb1*1501, dqb1*0602, and dqa1*0102 were also observed among the groups; however, none of these differences reached statistical significance between the controls and narcolepsy patients with or without cataplexy (table 1). |
| PubMedID- 24391530 | The orexin system plays a particularly important role in the normal expression of waking and sleep since its disruption underlies the sleep disorder narcolepsy with cataplexy in humans (peyron et al., 2000; thannickal et al., 2000) and produces a narcolepsy phenotype with unstable behavioral states, sleep attacks and cataplexy-like motor arrests in animals (chemelli et al., 1999; lin et al., 1999; hara et al., 2001; willie et al., 2003; beuckmann et al., 2004; mochizuki et al., 2004; kalogiannis et al., 2011). |
| PubMedID- 23939463 | Importance: idiopathic narcolepsy with cataplexy is thought to be an autoimmune disorder targeting hypothalamic hypocretin neurons. |
| PubMedID- 24727570 | Remarkably, narcolepsy with or without cataplexy with low/intermediate or normal cerebrospinal fluid hypocretin-1 is present in both diseases. |
| PubMedID- 20022299 | Rbd was idiopathic in 11 patients (1.6%; 9 men) and symptomatic in 23 patients (3.3%; 18 men) secondary to parkinsonian syndromes (n=11), use of antidepressants (n=7), narcolepsy with cataplexy (n=4), and pontine infarction (n=1). |
| PubMedID- 25534169 | Pseudo-cataplexy, a form of "psychogenic" narcolepsy, "pseudo-parasomnia" and pnes can have a similar presentation. |
| PubMedID- 21920673 | Recent results: antidepressants have long been used in control of narcolepsy with cataplexy, but their sustained efficacy in this role has been in question. |
| PubMedID- 25286384 | Orexins are bioactive peptides, which have been shown to play a pivotal role in vigilance state transitions: the loss of orexin-producing neurons (orexin neurons) leads to narcolepsy with cataplexy in the human. |
| PubMedID- 25277311 | narcolepsy with cataplexy is a sleep disorder caused by the loss of hypocretin-producing neurons in the hypothalamus. |
| PubMedID- 23646285 | Besides, our group has recently reported a clinical trial of oral l-carnitine on narcolepsy with cataplexy and the results suggested that oral l-carnitine can be a promising treatment for narcolepsy with cataplexy (miyagawa et al., 2013; miyagawa et al., 2011). |
| PubMedID- 21170044 | Growing evidence supports the hypothesis that narcolepsy with cataplexy is an autoimmune disease. |
| PubMedID- 23065655 | At the pathophysiological level, it is now clear that most narcolepsy cases with cataplexy, and a minority of cases (5–30 %) without cataplexy or with atypical cataplexy-like symptoms, are caused by a lack of hypocretin (orexin) of likely an autoimmune origin. |
| PubMedID- 22406785 | Mean age at onset of symptoms was 25+/-10 years; 12 (60%) patients had narcolepsy with cataplexy, 4 (20%) patients presented with all cardinal symptoms of narcolepsy, 8 (40%) with 3 symptoms, while 8 (40%) presented with 2 symptoms. |
| PubMedID- 23496005 | The aim of this study was to describe the clinical and psg characteristics of narcolepsy with cataplexy and their genetic predisposition by using the retrospective patient database of the european narcolepsy network (eu-nn). |
| PubMedID- 22937359 | Therefore, while a negative result may be suggestive that the possibility of narcolepsy with associated cataplexy is <10%, a positive result is nonspecific. |
| PubMedID- 24312261 | In summary, our study has demonstrated that brain morphometric abnormalities in the left amygdala, left inferior frontal gyrus, and left postcentral gyrus exist in narcolepsy with cataplexy, but not in narcolepsy without cataplexy. |
| PubMedID- 24416019 | Dko mice display the most profoundly disturbed sleep phenotype of all three models: narcolepsy with cataplexy (transient episodes of behavioral arrest) (kalogiannis et al., 2011). |
| PubMedID- 26251634 | Despite these limitations, the patients demonstrated clear symptoms of narcolepsy with cataplexy that were validated by objective testing. |
| PubMedID- 26418536 | No significant difference in the headache prevalence was observed between the narcolepsy patients with cataplexy (n = 44) and those without cataplexy (n = 24; headache, 45.5% vs. 50.0%: migraine, 25.0% vs. 20.8%; tension-type headache, 18.2% vs. 12.5%). |
| PubMedID- 20129934 | We hypothesized that rapid eye movement sleep behaviour disorder coexists with cataplexy in narcolepsy due to hypocretin deficiency. |
| PubMedID- 23372264 | Study objectives: we analyzed the potential predictive factors for precocious puberty, observed in some cases of childhood narcolepsy with cataplexy (nc) and for obesity, a much more common feature of nc, through a systematic assessment of pubertal staging, body mass index (bmi), and metabolic/endocrine biochemical analyses. |
| PubMedID- 19955018 | Methods: seven narcolepsy with cataplexy patients underwent daytime videopolygraphy using humorous movies or/and jokes to trigger cataplectic attacks. |
| PubMedID- 23228163 | The level of depressive and anxious symptoms in narcolepsy with cataplexy did not differ from the other groups. |
| PubMedID- 21931493 | She also found global loss of hypocretin neurons in the brains of six deceased patients who had suffered from narcolepsy with cataplexy.40 furthermore, thannickal et al found the number of hypocretin neurons to be reduced by 85% to 95% in association with evidence of gliosis.39 these studies collectively suggested that the loss of hypocretin neurons in patients having narcolepsy with cataplexy might be inflammatory in nature. |
| PubMedID- 20513636 | Our results show for the first time that narcolepsy without cataplexy, where the majority of cases have normal csf hypocretin levels, is associated with olfactory dysfunction. |
| PubMedID- 19555382 | Although a close association between human leucocyte antigen (hla) and human narcolepsy with cataplexy suggests an involvement of autoimmune mechanisms, this has not yet been proved. |
| PubMedID- 24406723 | narcolepsy with cataplexy is a sleep dysregulation disorder with alterations of rem sleep, i.e., sleep onset rem periods and rem sleep instability. |
| PubMedID- 24142146 | Clinical and biochemical evidence temporally links the onset of narcolepsy with cataplexy symptoms with an activation of the immune system by infection, either bacterial such as streptococcal (aran et al., 2009), or viral such as h1n1 flu or vaccination (han et al., 2011; partinen et al., 2012), or with an autoimmune response proved by production of self-targeted antibodies (cvetkovic-lopes et al., 2010; kawashima et al., 2010). |
| PubMedID- 20160349 | Elisa analysis showed that sera from narcolepsy patients with cataplexy had higher trib2-specific antibody titers compared with either normal controls or patients with idiopathic hypersomnia, multiple sclerosis, or other inflammatory neurological disorders. |
| PubMedID- 26090827 | Csf orexin levels <110 pg/ml supports a diagnosis of type 1 narcolepsy (narcolepsy with cataplexy). |
| PubMedID- 23772196 | narcolepsy with cataplexy mimicry: the strange case of two sisters. |
| PubMedID- 23616752 | Strong, generally positive emotional stimuli, which might activate the amygdala, are known to trigger cataplexy in narcolepsy-cataplexy patients. |
| PubMedID- 20927145 | According to the new classification, the multiple sleep latency test (mslt) is mandatory for diagnosing narcolepsy without cataplexy, and advisable for diagnosing narcolepsy with cataplexy. |
| PubMedID- 26074874 | In this review, we discuss how rem sleep-control mechanisms underlie the intrusion of rem sleep paralysis during wakefulness in narcolepsy with cataplexy, and how degeneration of this same circuitry could underlie rbd. |
| PubMedID- 24297759 | Methods: we enrolled 181 consecutive patients (108 men, 73 women; mean age 37.6 +/- 16.6 years old; narcolepsy with cataplexy/narcolepsy without cataplexy = 131:50). |
| PubMedID- 25325489 | Patient diagnoses included narcolepsy with cataplexy (28.4%), narcolepsy without cataplexy (8.1%), other hypersomnia conditions (9.5%), delayed sleep phase syndrome (12.2%), behaviorally induced insufficient sleep syndrome (4.1%), other sleep disorders (obstructive sleep apnea, periodic limb movements of sleep; 6.8%), isolated cataplexy (2%), and various diagnoses (29.1%). |
| PubMedID- 21658163 | Background and purpose: the second version of the international classification of sleep disorders suggests narcolepsy with cataplexy can be diagnosed on history alone. |
| PubMedID- 21210337 | Background: narcolepsy with cataplexy (nc) is caused by substantial loss of hypocretin neurons. |
| PubMedID- 20525256 | cataplexy (with or without narcolepsy), usually laughter-induced, is another more specific symptom . |