PedAM
Pediatric Disease Annotations & Medicines
| Disease | narcolepsy |
| Symptom | |cataplexy |
| Sentences | 180 |
| PubMedID- 23674942 | In one report, clonazepam was shown to improve cataplexy in 10 of 14 patients with narcolepsy although no improvement in daytime sleepiness was reported. |
| PubMedID- 24297328 | Disruption of the hypocretin system leads to narcolepsy with cataplexy in humans as well as in animal models (chemelli et al. |
| PubMedID- 24844961 | Methods: a total of 1 223 narcoleptic patients (nc, narcolepsy with typical cataplexy, n = 1 132; nwc, narcolepsy without cataplexy, n = 91) diagnosed at sleep center of peking university people's hospital from august 1998 to july 2011 were recruited into this retrospective study. |
| PubMedID- 21697009 | Background: narcolepsy with cataplexy (nc) is a disabling disorder characterized by excessive daytime sleepiness and abnormal rapid eye movement (rem) sleep manifestations, due to a deficient hypocretin/orexin neurotransmission. |
| PubMedID- 25098533 | Objective: conflicting data have been reported on resting autonomic tone in narcolepsy with cataplexy (nc), including reduced or increased sympathetic activity; to settle this important point, we aimed to measure the resting sympathetic and cardiovascular activities in patients with nc by direct microneurographic monitoring of muscle sympathetic nerve activity (msna) during wakefulness. |
| PubMedID- 25728441 | narcolepsy with cataplexy is caused by hypocretin deficiency owing to destruction of most of the hypocretin-producing neurons in the hypothalamus. |
| PubMedID- 22973425 | Central hypersomnias includes narcolepsy with and without cataplexy, recurrent hypersomnia, idiopathic hypersomnia, with and without long sleep time, behaviorally induced insufficient sleep syndrome, hypersomnia and narcolepsy due to medical conditions, and finally hypersomnia induced by substance intake. |
| PubMedID- 25969754 | Consistently, disruption of the orexin system leads to the sleep disorder narcolepsy with cataplexy in humans as well as in animal models . |
| PubMedID- 20967199 | narcolepsy with cataplexy was diagnosed based on the presence of excessive daytime sleepiness (eds) and cataplexy, hla dqb1*0602 positivity and of at least two sleep onset rem periods (soremps) during the mslt. |
| PubMedID- 24340297 | narcolepsy with cataplexy is rare in children under 5 years of age. |
| PubMedID- 22468916 | Areas covered: this review recapitulates on the current approaches for treating narcolepsy with cataplexy and the use of narcolepsy models in order to address different aspects of the disease. |
| PubMedID- 20862344 | Excessive daytime sleepiness (hypersomnia) is related to changes either in nrem (idiopathic hypersomnia), rem sleep (narcolepsy without cataplexy) or could be central in origin (narcolepsy with cataplexy). |
| PubMedID- 21148631 | Patients or participants: eight male hypocretin-deficient narcolepsy with cataplexy patients and eight controls matched for sex, age, body mass index, waist-to-hip ratio and fat percentage were enrolled. |
| PubMedID- 24048081 | Purpose of review: a number of european countries have reported a dramatic increase in the rates of childhood narcolepsy with cataplexy in children immunized with a split-virion adjuvanted swine flu vaccine. |
| PubMedID- 22841884 | narcolepsy with cataplexy is caused by a selective loss of hypocretin-producing neurons, but symptomatic narcolepsy can also result from hypothalamic and brainstem lesions caused by multiple sclerosis (ms). |
| PubMedID- 20689589 | narcolepsy with cataplexy is caused by a derangement of orexin (also known as hypocretin) signaling , . |
| PubMedID- 23689193 | Background: disturbed sleep is a core feature of narcolepsy with cataplexy (nc). |
| PubMedID- 23622291 | It can be secondary to brain tumors or several rare diseases, but in most cases narcolepsy with or without cataplexy is a primary condition, better explained by the selective loss of hypocretin neurons in posterolateral hypothalamus. |
| PubMedID- 22167152 | Objective: based on the clinical observation that patients suffering from narcolepsy with cataplexy (nc) have cataplectic attacks when they experience positive emotions, it is therefore hypothesised that the abnormal processing of external emotional input through the limbic system, or motor dysregulation induced by emotions, takes place during these episodes. |
| PubMedID- 23444425 | Results: case notes for 245 children and young people were reviewed; 75 had narcolepsy (56 with cataplexy) and onset after 1 january 2008. |
| PubMedID- 24784789 | Background: the association between narcolepsy with cataplexy and the hypocretinergic system in the central nervous system is strong since up to 75-90% of all patients have cerebrospinal fluid (csf) hypocretin-1 deficiency. |
| PubMedID- 23827430 | narcolepsy with cataplexy is also rare in children younger than 5 years of age. |
| PubMedID- 22470453 | Our finding is supported by the recent results from sweden, where a cohort study covering the entire population reported an almost 7-fold incidence of narcolepsy with cataplexy in children vaccinated with pandemrix compared to those in the same age group who were not vaccinated 4. |
| PubMedID- 21655207 | Other important differential diagnosis include narcolepsy with and without cataplexy, idiopathic hypersomnia with and without long sleep time, recurrent hypersomnia, behaviorally induced insufficient sleep syndrome, hypersomnia due to medical condition, hypersomnia due to drug or substance, hypersomnia not due to a substance or known physiologic condition, and also sleep-related disordered breathing and periodic leg movement disorders. |
| PubMedID- 23452773 | narcolepsy (with or without cataplexy), idiopathic hypersomnia (with or without long sleep duration) and kleine - levin syndrome are the main central rare hypersomnias. |
| PubMedID- 23946711 | Results: a total of 100 consecutive narcolepsy patients (87 with cataplexy nc, 13 without cataplexy n) were included in the analysis. |
| PubMedID- 22055895 | Objectives: gamma-hydroxybutyrate (ghb) is currently authorized by the european medicines agency (ema) to treat narcolepsy with cataplexy in adults, and by the food and drug administration (fda) to treat cataplexy in patients with narcolepsy, with an expanded indication for the treatment of excessive daytime sleepiness. |
| PubMedID- 25165990 | Hypocretin deficiency appears to underlie narcolepsy with cataplexy, and infections and vaccinations have been associated with disease onset. |
| PubMedID- 24635684 | narcolepsy with cataplexy is a complex sleep disorder that affects the modulation of emotions: cataplexy, the key symptom of narcolepsy, is indeed strongly linked with emotions that usually trigger the episodes. |
| PubMedID- 25600782 | Pain perception in narcolepsy with cataplexy patients. |