PedAM
Pediatric Disease Annotations & Medicines
| Disease | narcolepsy |
| Symptom | |cataplexy |
| Sentences | 180 |
| PubMedID- 23772198 | narcolepsy with cataplexy associated with sleep-related rhythmic movements. |
| PubMedID- 21173745 | Background: narcolepsy with cataplexy (nc) differs from narcolepsy without cataplexy (nwoc) in the cerebrospinal fluid levels of hypocretin. |
| PubMedID- 24470783 | As is the case in narcolepsy with cataplexy, an autoimmune mechanism has been suggested; however, the evidence is much less robust in kleine-levin syndrome. |
| PubMedID- 24293310 | narcolepsy with cataplexy is a severely disabling disorder very often arising in childhood. |
| PubMedID- 23385692 | Breakdown in this circuitry both results in and explains the manifestations of a variety of sleep disorders including insomnia, narcolepsy with cataplexy, and rem sleep behavior disorder. |
| PubMedID- 20576035 | As disruption of orexin (hypocretin) signaling is a primary defect in narcolepsy with cataplexy, we investigated whether markers of cholinergic synaptic transmission might be altered in mice constitutively lacking orexin receptors (double receptor knockout; dko). |
| PubMedID- 20540992 | Orexin (orx or hypocretin) is critically important for maintaining wakefulness, since in its absence, narcolepsy with cataplexy occurs. |
| PubMedID- 24994458 | Nine healthy controls and twenty-one narcolepsy patients with cataplexy were studied. |
| PubMedID- 23821583 | Results: we found an average 64% increase in the number of histamine neurons in human narcolepsy with cataplexy, with no overlap between narcoleptics and controls. |
| PubMedID- 26313387 | We present the case of an 86 year old female, in whom narcolepsy with cataplexy (nc) manifested at 52 years of age. |
| PubMedID- 23288981 | Study objectives: although hypothesized through animal studies, a temporal and causal association between hypocretin deficiency and the onset of narcolepsy with cataplexy (nc) has never been proven in humans. |
| PubMedID- 24268496 | Our case-control study aimed to compare clinical differences and analyze risk factors in children who developed narcolepsy with cataplexy (n-c), schizophrenia, and n-c followed by schizophrenia. |
| PubMedID- 22768053 | The latter choice may be considered as particularly difficult as narcolepsy with cataplexy is an orphan disease associated with several comorbid conditions such as obesity. |
| PubMedID- 21486708 | Conclusions: the multimodal, dreamlike aspect of hallucinations in narcolepsy with cataplexy could transiently impair the patients' insight. |
| PubMedID- 26289164 | Caused by the complete loss of hcrt neurons, perhaps by an autoimmune process, the hcrt concentration in cerebrospinal fluid (csf) of patients suffering from narcolepsy with cataplexy is low to undetectable . |
| PubMedID- 24701532 | There are two distinct subgroups of narcolepsy: narcolepsy with cataplexy and narcolepsy without cataplexy. |
| PubMedID- 26316206 | narcolepsy with cataplexy, which may potentially mimic a seizure event, has also been reported in labrador retrievers . |
| PubMedID- 21484510 | Purpose: this study aims to report on catathrenia occurring in narcolepsy with cataplexy (nc) patients under sodium oxybate (so) treatment. |
| PubMedID- 20810310 | Injurious rem sleep behaviour disorder in narcolepsy with cataplexy contributing to criminal proceedings and divorce. |
| PubMedID- 22547897 | We retrospectively evaluated 27 children ranging from 6 to 16 years old, suffering from narcolepsy with cataplexy, who had been treated with off-label sodium oxybate and had been followed in a clinical setting. |
| PubMedID- 20373351 | narcolepsy with cataplexy is a sleep-wake disorder caused by a loss of hypothalamic hypocretins. |
| PubMedID- 20131387 | narcolepsy with cataplexy associated with holoprosencephaly misdiagnosed as epileptic drop attacks. |
| PubMedID- 25576137 | narcolepsy with and without cataplexy, idiopathic hypersomnia with and without long sleep time: a cluster analysis. |
| PubMedID- 19732319 | In this population-based case-control study, we sought to identify all prevalent cases of narcolepsy with cataplexy aged 18-50 years as of 1 july 2001, in king county, washington. |
| PubMedID- 22470463 | The incidence is estimated to be 0.74 per 100 000 person-years for narcolepsy with cataplexy and 1.37 per 100 000 person-years for narcolepsy with or without cataplexy 2. |
| PubMedID- 26392230 | Each patient was diagnosed as one of the following four categories: (1) narcolepsy with cataplexy (n + c; n = 29); (2) narcolepsy without cataplexy (n - c; n = 22); (3) idiopathic hypersomnia (ih; n = 24); and (4) subjective hypersomnolence (sh; n = 33) with mean sleep latency >8 min. |
| PubMedID- 26045680 | It is thought likely that narcolepsy with cataplexy only manifests when a patient has lost nearly all hypocretin cells. |
| PubMedID- 20469811 | Restless legs syndrome is frequent in narcolepsy with cataplexy patients. |
| PubMedID- 22783726 | The objective of this study was to perform global gene expression profiling of patients affected by narcolepsy with cataplexy (nrlcp). |
| PubMedID- 24694762 | In humans, narcolepsy with cataplexy (narcolepsy) is a sleep disorder that is characterized by sleepiness, cataplexy and rapid eye movement (rem) sleep abnormalities. |
| PubMedID- 23773727 | Conclusion: the data collected during 3 years following vaccination showed a significantly increased risk for narcolepsy with cataplexy (p<.0001) and reduced csf hypocretin levels in vaccinated children ages 4-19 years the first year after pandemrix(r) vaccination, with a minimum incidence of 10 of 100,000 individuals per year. |
| PubMedID- 22505866 | narcolepsy with cataplexy masked by the use of nicotine. |
| PubMedID- 23997366 | Objective: to investigate the effect of psychostimulants on impulsivity, depressive symptoms, addiction, pathological gambling, and risk-taking using objective sensitivity tests in narcolepsy with cataplexy (nc). |
| PubMedID- 24574957 | Importantly, patients suffering from narcolepsy with cataplexy, a condition associated with a disrupted ox/hcrt system, experience a higher frequency of pain (dauvilliers et al., 2011). |
| PubMedID- 21463040 | Objective: narcolepsy with cataplexy (nc) affects neurotransmitter systems regulating emotions and cognitive functions. |
| PubMedID- 21679260 | Month of birth is not a risk factor for narcolepsy with cataplexy in the netherlands. |
| PubMedID- 22171205 | Study objectives: the possible relationship between cerebrospinal fluid (csf) hypocretin and leptin levels, overweight, and association to risk factors for diabetes 2 in narcolepsy with cataplexy were compared to patients with idiopathic hypersomnia and controls. |
| PubMedID- 24363104 | narcolepsy with cataplexy is a neurological disorder regarded as a disease model for the selective hypocretin system damage, and also shares several psychopatological traits and comorbidities with psychiatric disorders. |
| PubMedID- 24825961 | Patients predisposed to rbd and later parkinsonism might be susceptible to a variety of triggers that, in our patient, might have been represented by a possible latent autoimmune process leading to the development of narcolepsy with cataplexy and rheumatoid arthritis, later. |
| PubMedID- 22309460 | The sleep-wake disorder narcolepsy with cataplexy is associated with the loss of hypocretin-(orexin-) producing neurons in the lateral hypothalamus. |
| PubMedID- 21234339 | In fact, a medline search yielded over 30 cases of secondary narcolepsy without cataplexy during the last 50 years, but yielded only 13 cases with secondary cataplexy. |
| PubMedID- 23946710 | Methods: eight male, medication free, hypocretin deficient, narcolepsy with cataplexy patients, and 8 healthy controls matched for age, sex, body mass index (bmi), waisttohip ratio, and body fat percentage were assessed. |
| PubMedID- 24882899 | The proportions for narcolepsy with and without cataplexy were 0.07% (95% ci: 0.02-0.37%) and 0.20% (95% ci: 0.07-0.58%), respectively. |
| PubMedID- 26483903 | narcolepsy with cataplexy is a rare sleep disorder with a neurological basis which has been recently linked to h1n1 vaccination either in children or adults. |
| PubMedID- 25750784 | However, because the sample size of narcolepsy with cataplexy was small, no analyses comparing classification accuracy for those with or without cataplexy were reported here. |
| PubMedID- 21723190 | Objectives: to compare differences in nocturnal and daytime polysomnographic findings between narcolepsy (na) with and without cataplexy (ca) and idiopathic hypersomnia without long sleep time (ihs w/o lst). |
| PubMedID- 23521426 | Introduction: narcolepsy with cataplexy is a rare disabling sleep disorder characterized by two major symptoms: excessive daytime sleepiness and cataplexy characterized by a sudden bilateral loss of voluntary muscular tone triggered by strong positive emotional factors. |
| PubMedID- 21713070 | Additionally, it has recently been shown that orexin-a, primarily deficient in narcolepsy with cataplexy, modulates pupil size (schreyer et al., 2009) and maybe a marker of hypocretin deficiency rather than a measure of alertness alone in narcolepsy with cataplexy (plazzi et al., 2011). |
| PubMedID- 25707395 | Finally, our classifiers could be used to identify the risk haplotypes for japanese narcolepsy with cataplexy, hla-drb1*15:01 and hla-dqb1*06:02, with 100% and 99.7% accuracy, respectively; therefore, these classifiers can be used to supplement the current lack of hla genotyping data in widely available genome-wide association study data sets. |
| PubMedID- 24645699 | narcolepsy with cataplexy and comorbid immunopathological diseases. |