PedAM
Pediatric Disease Annotations & Medicines
| Disease | narcolepsy |
| Symptom | |cataplexy |
| Sentences | 180 |
| PubMedID- 23734110 | narcolepsy with cataplexy (nc) is a rare debilitating neurological disorder that affects approximately 0.026% of the general population. |
| PubMedID- 24033681 | narcolepsy with cataplexy (nc) is a lifelong disorder caused by loss of hypothalamic hypocretin/orexin (hcrt) neurones, often starting in childhood. |
| PubMedID- 22942503 | Study objectives: to compare clinical, electrophysiologic, and biologic data in narcolepsy without cataplexy with low ( 200 pg/ml) concentrations of cerebrospinal fluid (csf) hypocretin-1. |
| PubMedID- 20810312 | Methods: nineteen drug-naive narcolepsy patients with cataplexy (10 males, 9 females, and mean age 28.5 years) and 25 age- and sex-matched healthy controls were recruited. |
| PubMedID- 21347440 | The hypocretin/orexin (hcrt/orx) neurons of the hypothalamus play an important role in maintaining arousal, since their absence results in narcolepsy with cataplexy (for reviews, see ). |
| PubMedID- 23643651 | Background: to test if the hypocretin (orexin) neuropeptide precursor (hcrt) gene, hcrt, mutations are implicated in the development of narcolepsy with cataplexy deficiency in young children. |
| PubMedID- 24368893 | In humans, orexin deficiency leads to narcolepsy with cataplexy (nishino et al., 2000). |
| PubMedID- 25325462 | Dqb1 locus alone explains most of the risk and protection in narcolepsy with cataplexy in europe. |
| PubMedID- 21570344 | Background: narcolepsy with cataplexy (nc) is caused by the loss of hypocretin neurons. |
| PubMedID- 24381371 | Dqb1 locus alone explains most of the risk and protection in narcolepsy with cataplexy in europe. |
| PubMedID- 24363733 | The drug is recommended in obsessive compulsive disorders (ocd), in cataplexy associated with narcolepsy, and in depression when sedation is required (5-7). |
| PubMedID- 23219054 | narcolepsy without cataplexy is a condition rarely associated with hypocretin deficiency. |
| PubMedID- 26227560 | Following the mass vaccinations against pandemic influenza a/h1n1 virus in 2009, a sudden increase in juvenile onset narcolepsy with cataplexy (nc) was detected in several european countries where as03-adjuvanted pandemrix vaccine had been used. |
| PubMedID- 20833530 | We report the management of a morbidly obese parturient suffering from narcolepsy with cataplexy who presented for caesarean section. |
| PubMedID- 25784528 | narcolepsy with cataplexy in an elderly woman. |
| PubMedID- 23514569 | Globally, a high frequency of depressive symptoms has been systematically reported in narcolepsy with cataplexy, supporting the hypothesis of an endogenous depression . |
| PubMedID- 24575043 | Patients that suffer from narcolepsy with cataplexy have very low levels of hcrt-1 in their csf (nishino et al., 2000; peyron et al., 2000; thannickal et al., 2000). |
| PubMedID- 20451031 | narcolepsy with cataplexy is a rare but life-long and challenging disorder. |
| PubMedID- 22467990 | Study objective: narcolepsy with cataplexy (nc) is associated with loss of hypocretin neurons in the lateral hypothalamus involved in the circadian timing of sleep and wakefulness, and many biologic functions including autonomic control. |
| PubMedID- 22406786 | We present a case of narcolepsy with cataplexy with classical clinical and polysomnographic findings of narcolepsy. |
| PubMedID- 23616586 | narcolepsy with cataplexy is characterized by irresistible bouts of sleep during the day, sleep fragmentation during the night and episodes of cataplexy, a sudden loss of muscle tone while awake and experiencing emotions. |
| PubMedID- 22558075 | narcolepsy with cataplexy (nc) is a rare disabling disorder characterized by excessive daytime sleepiness (eds), cataplexy, and other dissociated manifestations of rapid eye movement (rem) sleep phenomena such as sleep paralysis and hypnagogic hallucinations 1. |
| PubMedID- 21633708 | Background: narcolepsy with cataplexy (nc) is currently thought to be an autoimmune-mediated disorder in which environmental risk factors make a significant contribution to its development. |
| PubMedID- 21966067 | Localized cortical thinning in narcolepsy patients with cataplexy was found in orbitofrontal gyri, dorsolateral and medial prefrontal cortexes, insula, cingulate gyri, middle and inferior temporal gyri, and inferior parietal lobule of the right and left hemispheres at the level of a false discovery rate p<0.05. |
| PubMedID- 24376396 | narcolepsy with cataplexy is associated with severe daytime sleepiness (tafti et al., 2005) due to the complete disorganization of the sleep/wake cycle, with sudden onset of rapid eye movement (rem) sleep and cataplexy (loss of skeletal muscle tone without the loss of consciousness triggered by emotions). |
| PubMedID- 20181520 | Objective: to test the autonomic control of cardiovascular reflexes and heart rate variability (hrv) at rest and during orthostatic stress in narcolepsy with cataplexy (nc). |
| PubMedID- 24650212 | narcolepsy with cataplexy is caused by a deficiency in the production of hypocretin/orexin, which regulates sleep and wakefulness, and also influences appetite, neuroendocrine functions and metabolism. |
| PubMedID- 20337187 | Study objectives: narcolepsy with cataplexy is caused by a loss of orexin (hypocretin) signaling, but the physiologic mechanisms that result in poor maintenance of wakefulness and fragmented sleep remain unknown. |
| PubMedID- 24796285 | Our main goal was to study different types of oneiric activity in narcolepsy with cataplexy (nc) and narcolepsy without cataplexy (n). |
| PubMedID- 20403960 | Human narcolepsy with cataplexy is a neurological disorder, which develops due to a deficiency in hypocretin producing neurons in the hypothalamus. |
| PubMedID- 23036267 | Results: the 139 patients (45% men) aged 36+/-15years (range: 9-74) suffered narcolepsy (n=94, 66% with cataplexy), idiopathic (n=37) and symptomatic hypersomnia (n=8) refractory to modafinil, methylphenidate and sodium oxybate. |
| PubMedID- 26518595 | Design: hla class i (a, b, and c) and ii (dqb1) genotypes were analyzed in 944 european narcolepsy with cataplexy patients and in 4043 control subjects matched by country of origin. |
| PubMedID- 23526549 | This article reviews the contribution of neuroimaging to the pathophysiology of narcolepsy with cataplexy, focusing on the most recent developments. |
| PubMedID- 23326757 | narcolepsy with cataplexy is characterized by loss of hypocretin-containing cells in the lateral hypothalamus. |
| PubMedID- 23853567 | Status cataplecticus is a rare manifestation of narcolepsy with cataplexy episodes recurring for hours or days, without a refractory period, in the absence of emotional triggers. |
| PubMedID- 24169281 | Methods: a total of 139 narcoleptic patients, including 111 narcolepsy with typical cataplexy (nc) and 28 narcolepsy without cataplexy (nwc), were diagnosed at the sleep centre of peking university people's hospital from april 2003 to march 2012. |
| PubMedID- 21966068 | narcolepsy with cataplexy associated with nocturnal compulsive behaviors: a case-control study. |
| PubMedID- 23739971 | narcolepsy with cataplexy is caused by a loss of orexin (also known as hypocretin) signaling, but almost nothing is known about the neural mechanisms through which positive emotions trigger cataplexy. |
| PubMedID- 22435405 | The autoimmune sleep disorder narcolepsy with cataplexy is caused by a loss of hypocretin-producing neurons in the brain . |
| PubMedID- 23802043 | narcolepsy with cataplexy is perhaps the best investigated among these. |
| PubMedID- 24780136 | The international classification of sleep disorders, second edition (icsd-2) criteria, were used to classify sleep disorders (e.g., delayed sleep phase disorder, hypersomnia, narcolepsy with cataplexy nc, restless legs syndrome rls, periodic limb movement disorder plmd, insomnia, rapid eye movement sleep behavior disorder rbd, and obstructive sleep apnea osa). |
| PubMedID- 24468101 | Objectives: we aimed to compare post-pandemrix vaccination (postvaccine) childhood narcolepsy with cataplexy (nc) vs. |
| PubMedID- 22249484 | Such guidelines state that the determination of csf hypocretin levels is mandatory only in cases of narcolepsy without cataplexy or in patients with negative multiple sleep latency test results. |
| PubMedID- 26062517 | Symptomatic narcolepsy, with or without cataplexy has also been reported in up to 35.7 % of children with pws . |
| PubMedID- 21532956 | In addition, narcolepsy with cataplexy in our clinic population appeared to begin at a younger age than usually reported in other studies. |
| PubMedID- 23026503 | Objective: to investigate in narcolepsy with cataplexy (nc) patients of working age (18-65 years) the influence of age at onset, age at diagnosis and clinical features on socio-occupational conditions, disease-related economic burden, and quality of life. |
| PubMedID- 23616702 | Methylphenidate and dextroamphetamine are approved in this indication, although these medications have the potential for abuse and their use should therefore be monitored closely.50 sodium oxybate has been shown to significantly reduce es and cataplexy in patients with narcolepsy in randomized clinical trials and it is the only fda-approved medication for the treatment of both of these symptoms.51–54 modafinil and armodafinil have been shown to address es in patients with narcolepsy in randomized controlled trials55–57 and are approved by the fda for this indication. |
| PubMedID- 26074743 | However, because there are also legitimate medical uses for ghb, such for cataplexy attacks in patients with narcolepsy, in the form of sodium oxybate ghb was placed in schedule iii as xyrem®. |
| PubMedID- 23649748 | This diagnosis was defined as narcolepsy associated with cataplexy plus hla-dqb1*06:02 positivity (no cerebrospinal fluid hypocretin-1 results available) or narcolepsy with documented low ( |
| PubMedID- 25271675 | narcolepsy with cataplexy patients have more sleep-wake transitions during night, suggesting instability in the sleep-wake regulatory system. |