PedAM
Pediatric Disease Annotations & Medicines
| Disease | asthma |
| Phenotype | C0028754|obesity |
| Sentences | 111 |
| PubMedID- 22375278 | A number of studies have linked obesity with asthma in adults and children. |
| PubMedID- 23692648 | Furthermore, obesity is associated with less asthma control and more use of oral corticosteroids [6,7]. |
| PubMedID- 20701611 | Objective: the aim of this study was to investigate whether differences in high-sensitivity c-reactive protein (hs-crp) levels explain why obesity is associated with asthma in females but not in males. |
| PubMedID- 26542296 | Adipokines may change the t helper cell balance in favor of a t helper cell type 1 (th1) response, as it is seen in asthma associated with obesity [59,60]. |
| PubMedID- 24166939 | Rationale: previous studies showed that obesity in asthmatic children is associated with more severe exercise-induced bronchoconstriction (eib), compared with non-obese asthmatic children. |
| PubMedID- 24600294 | In a cross-sectional case control study of over 1100 children aged 5–18 years recruited from a single outpatient allergy/immunology clinic, investigators asked whether obesity was associated with allergic asthma in children.25 they were specifically interested in whether the distribution of obesity was important in the relationship between obesity and asthma diagnosis, lung function, and symptom burden. |
| PubMedID- 24454412 | The possibility that asthma may lead to obesity is less controversial, because of fear of exercise or inability to exercise regularly. |
| PubMedID- 25742612 | Background: obesity is associated with poor asthma control, increased asthma morbidity, and decreased response to inhaled corticosteroids. |
| PubMedID- 24885269 | After adjusting for sex, age, andco-morbidities, including obesity, patients with asthma developed ckd (hr: 1.13 [1.07-1.19], p < 0.001) compared to hr before the adjustments (hr: 1.56 [1.48-1.64], p < 0.001) (table 3). |
| PubMedID- 23619597 | There is mounting evidence that obesity is associated with asthma, both of which are seeing a dramatic increase in prevalence. |
| PubMedID- 23661915 | [56] the interaction of obesity with asthma is variable. |
| PubMedID- 23273317 | A possible explanation for this results might be a selection bias, in particular overdiagnosis of asthma attributable to non specific obesity-related respiratory symptoms among obese children. |
| PubMedID- 23035704 | On the contrary, a previous diagnosis of asthma was associated with obesity, or = 1.48 (1.01 - 2.16) for body mass index ≥ 30 kg/m2; or = 1.48 (1.13 - 1.93) for abnormal waist-to-height ratio; and, or = 1.32 (1.00 – 1.75) for abnormal waist circumference. |
| PubMedID- 20334698 | The cross sectional nature of this study prevents conclusions on a causal relationship between asthma with obesity or psychological well-being in ethnic minorities. |
| PubMedID- 22609068 | obesity is associated with poor asthma control, but the reason for this is unclear. |
| PubMedID- 22092883 | obesity is associated with increased asthma severity and exacerbations, and increased serum immunoglobulin e in inner-city adults. |
| PubMedID- 23923994 | Conclusions: obesity in asthmatics is associated with shorter and very long sleep duration, worse asthma severity, psychopathology and high-dose inhaled corticosteroids. |
| PubMedID- 23258582 | Furthermore, obesity is associated with poorer asthma control, as assessed by asthma control questionnaires, limitations in daily activities, breathlessness and wheezing, use of rescue medication, unscheduled doctor visits, emergency department visits, and hospitalizations for acute asthma. |
| PubMedID- 26111352 | Background: obesity is associated with asthma risk and severity, but the underlying biological mechanisms are poorly understood. |
| PubMedID- 26441284 | However, another study showed obesity was not associated with asthma prevalence in preschool children [25]. |
| PubMedID- 20456316 | obesity was positively associated with asthma overall (odds ratio [or] for obese vs normal bmi = 2.28, 95% ci: 1.76, 2.96; or for obese vs normal waist circumference = 1.75; 95% ci: 1.22, 2.51) but insulin resistance was not (or = 1.26; 95% ci: 0.80, 1.98). |
| PubMedID- 22360643 | Even in preschool children, obesity is already associated with asthma, and there was no gender effect on this association. |
| PubMedID- 26006753 | Conclusion: our data confirm that both underweight and obesity are associated with current asthma and obesity with copd. |
| PubMedID- 22768385 | obesity in children with asthma appears to be associated with greater airflow obstruction and a mildly diminished response to inhaled corticosteroids. |
| PubMedID- 24336249 | However, as the number of ilc3 cells varied considerably in the bal fluid of the 10 patients examined, the precise role of ilc3 cells in human lung disease, including asthma associated with obesity, will require clinical studies with much larger numbers of patients. |
| PubMedID- 24008330 | The joint association of anxiety, depression and obesity with incident asthma in adults: the hunt study. |
| PubMedID- 22379605 | obesity leads to more severe asthma symptoms in children. |
| PubMedID- 24821412 | Fits of a mathematical model of lung mechanics to these impedance spectra suggest that the lung periphery was more collapsed by obesity in patients with asthma compared with control subjects. |
| PubMedID- 22926907 | [bronchial asthma in obesity--a distinct phenotype of asthma. |
| PubMedID- 22931550 | obesity has been associated with asthma [1,40,41]. |
| PubMedID- 26225211 | Despite more than a decade of research into this association, the exact mechanisms that underlie the interaction of obesity with asthma remain unclear. |
| PubMedID- 22726248 | Figure 2 illustrates the component of metabolic syndrome found in this population of asthma patients with abdominal obesity being the most prevalent and elevated triglyceride the least. |
| PubMedID- 24809015 | Many clinical studies showed the consistent association of obesity with asthma in terms of causal relationship, dose-dependency, and reversal of asthma by intervention, although the precise mechanism between obesity and asthma remains unclear [2, 3, 4, 5, 6]. |
| PubMedID- 22540290 | A heavy burden is more common in asthmatics with obesity, frequent respiratory symptoms and low lung function. |
| PubMedID- 23311506 | We assessed the independent association of these snps and obesity with asthma prevalence and incidence. |
| PubMedID- 22326605 | Methods: in this prospective study, 12 asthmatic patients with severe obesity were evaluated before, 6 and 12 months after bariatric surgery. |
| PubMedID- 23392439 | Rationale: obesity is associated with increased asthma morbidity, lower drug responsiveness to inhaled corticosteroids, and worse asthma control. |
| PubMedID- 26365093 | Association of asthma with obesity among adolescents exposed to environmental tobacco smoke. |
| PubMedID- 23902719 | Many studies evaluated the relationship between feno and obesity in asthmatic patients showing no significant relationship between feno and body mass index in asthmatic subjects, and suggesting that childhood obesity is not associated with increased airway inflammation[7,11,37,38]. |
| PubMedID- 26426429 | Across all age groups, obesity was associated with poorer asthma outcomes: either poor asthma control (odds ratio (or)=2.3, 95% confidence interval (ci) 1.1–4.7 in 5- to 11-year-olds and or=1.5, 95% ci 1.1–2.2 in adults) or asthma exacerbations (or 2.9, 95% ci 1.6–5.1 in 12- to 18-year-olds and or 1.7, 95% ci 1.1–2.5 in adults). |
| PubMedID- 24807420 | These conditions are influenced by genetic and environmental factors, and several studies have found obesity to be associated with asthma in both adult and paediatric populations [4,5]. |
| PubMedID- 23355113 | Background: obesity is associated with poor asthma outcomes; weight loss improves such outcomes. |
| PubMedID- 21525083 | In adolescents, approximately 20% received recommended laboratory screening and overweight/ obesity was significantly associated with chart-documented asthma, back pain, prediabetes, gastroesophageal reflux disease, hypertension, and sleep apnea. |
| PubMedID- 26226354 | obesity is independently associated with decreased asthma control. |
| PubMedID- 20334686 | On a population basis, the high prevalence of obesity among adults with asthma suggests an important opportunity to improve the lives of many such individuals. |
| PubMedID- 24182891 | Prevalence of obesity in asthma and its relations with asthma severity and control. |
| PubMedID- 25191399 | Association of obesity with asthma severity, control and quality of life. |
| PubMedID- 21944975 | Major conclusions: obesity is associated with poor asthma control, altered responsiveness to medications and increased morbidity. |
| PubMedID- 22653771 | Odds ratios for asthma associated with obesity were calculated using multivariable logistic regression. |
| PubMedID- 23941287 | The pro-inflammatory role of leptin and resistin support the hypothesis that obesity may lead to new-onset (incident) asthma, which is also an inflammatory condition [14,15]. |