PedAM
Pediatric Disease Annotations & Medicines
| Disease | asthma |
| Phenotype | |obesity |
| Sentences | 111 |
| PubMedID- 24669757 | Low physical fitness levels and high screen time increase the risk of central obesity, which leads to asthma development. |
| PubMedID- 26252510 | Results: the comparison of gene expression profiles between asthmatic patients with obesity and those with normal body mass revealed a significant difference in 6 genes. |
| PubMedID- 25979684 | Moreover, all the degrees of obesity are associated with asthma (or type i obesity: 1.33; or type ii obesity: 1.69; or type iii obesity: 1.75), heart failure (or type i obesity: 1.68; or type ii obesity: 2.78; or type iii obesity: 4.35), and severe mental disorders (or type i obesity: 2.02; or type ii obesity: 2.33; or type iii obesity: 2.50). |
| PubMedID- 25947112 | Although the mechanisms linking obesity with asthma expression have not been completely elucidated, evidence suggests that increased frequency of acute respiratory infection (ari) and decreased corticosteroid responsiveness may help to explain how obesity worsens asthma expression. |
| PubMedID- 23646295 | Objective: we hypothesized that asthmatic children with obesity, defined as a body mass index above the 95th percentile for age and sex, would have poorer asthma control as well as decreased quality of life, increased health care utilization, and decreased pulmonary function measures as a function of increased th1 versus th2 polarization. |
| PubMedID- 23297741 | It is possible that obesity is truly associated with atopic asthma but our data had a low statistical power to detect such an association. |
| PubMedID- 25975622 | Conclusions: elevated bmi, particularly obesity, is associated with subsequent poor asthma control, especially in the risk domain (exacerbations). |
| PubMedID- 25638180 | Results: after adjusting for confounding factors, maternal smoking during pregnancy, preterm birth and obesity were significantly associated with persistent asthma, with adjusted ors (95% ci) of 2.11 (1.08- 4.13), 2.61(1.07-6.35) and 2.89 (1.49-5.61), respectively. |
| PubMedID- 25849982 | Interestingly, a similar developmental pattern was observed in offspring of mice exposed to human igg antibodies of mothers with a child diagnosed with autism.50 prenatal exposure to environmental insults, including factors contributing to allergies and asthma, are associated with childhood obesity,51 a condition that includes both systemic and neuro-inflammation.52 increased weight gain in offspring of maa dams may represent priming and reprogramming of metabolic function through both immune and nervous system mechanisms, as has been previously hypothesized.53, 54 in fact, a recent examination of metabolic changes in immune cells of mice born to dams exposed to a viral mimic revealed persistent mitochondrial dysfunction in splenocytes.55, 56 interestingly, comorbid metabolic dysregulation is highly prevalent in neurodevelopmental disorders including asd,57 adhd58 and schizophrenia,59 suggesting that environmental insults may impart pervasive changes in homeostasis and regulation across organ systems. |
| PubMedID- 21999468 | obesity was also associated with increased atopic asthma (aor 1.98, 95% ci 1.47-2.66, p<0.0001), but not associated with nonatopic asthma (p=0.20), atopic or nonatopic rhinoconjunctivitis (p=0.08 and 0.31, respectively), food allergies (p=0.67 and 0.35, respectively) or atopy (p=0.40). |
| PubMedID- 24947900 | asthmatics with obesity and those with symptoms of depression both had a higher risk of having poorly controlled asthma (adjusted odds ratio of 1.83 ci 1.23-3.52 for obesity, and 2.08 ci 1.23-3.52 for depression), but there was no interaction between the two. |
| PubMedID- 24142648 | We used the same mouse model of chronic asthma with or without obesity as we previously described.10 mice were divided into 4 groups: a control group, an asthma group, an obese group, and an obese asthma group. |
| PubMedID- 23010231 | Conclusion: given the differences between areas and the associations between environmental risk factors and obesity with asthma and wheeze, the study findings support environment and health risk behavior explanations for the observed geographic variations. |
| PubMedID- 21773007 | Measures of obesity associated with asthma diagnosis in ethnic minority children. |
| PubMedID- 23176705 | Finally, studies have demonstrated that obesity was associated with poor asthma control [37,38] and poor response to ics treatment [39]. |
| PubMedID- 24220581 | Overweight and obesity were associated with increased asthma severity in all of the patients and with worse control of the disease among the patients with more severe disease, older patients and patients with a longer duration of asthma. |
| PubMedID- 22520186 | obesity was particularly associated with apoplexy, paralysis, asthma and putrid fevers, and a range of therapeutic options was proposed. |
| PubMedID- 23710196 | Although obesity is associated with less asthma control, greater risk of asthma exacerbations, and reduced inhaled corticosteroid efficacy, whether in fact these conditions are causally related remains uncertain [1]. |
| PubMedID- 23828644 | Mouse studies have helped us to uncover the underlying inflammatory mechanisms (mediated by multiple immune cell types that produce th1, th2 or th17 cytokines) and non-inflammatory pathways, in addition to shedding light on asthma that is associated with obesity or steroid unresponsiveness. |
| PubMedID- 21992497 | Despite more than a decade of research into this association, the exact mechanisms that underlie the interaction of obesity with asthma remain unclear. |
| PubMedID- 21151697 | To date studies of obesity in asthma have focussed upon the body mass index (bmi), although a criticism of the bmi is that it does not take into account body composition. |
| PubMedID- 22133422 | Multivariate logistic regression was used to examine adjusted associations of sdb and obesity with asthma severity at 12-month follow-up. |
| PubMedID- 24409194 | There are also several clinical observations suggesting the role of obesity with asthma and one of the major conclusions so far has been the action of adipocytes derived cytokines which inhibit the activity of t-regs thus decreasing the tolerance (theoharides et al., 2008). |
| PubMedID- 20525713 | The obesity phenotype associated with asthma is not known. |
| PubMedID- 23710195 | Role of obesity in asthma control, the obesity-asthma phenotype. |
| PubMedID- 24548172 | Gender-specific differences in associations of overweight and obesity with asthma and asthma-related symptoms in 30 056 children: result from 25 districts of northeastern china. |
| PubMedID- 26442312 | [treatment of patients with bronchial asthma associated with obesity in a health resort "okeanskiy"]. |
| PubMedID- 23240044 | Overweight and obesity do not lead to asthma in asian immigrant children in usa [34]. |
| PubMedID- 23420493 | They have been implicated in lipid digestion and obesity, activation of immune cells, asthma, atherosclerosis, acute respiratory distress syndrome and host defense against bacteria, viruses and parasites (5–8). |
| PubMedID- 24274607 | Conclusions: our study found an increased prevalence of obesity in children with asthma, with a predominance in male gender, and showed a high association between the severity of asthma and increased bmi. |
| PubMedID- 26538828 | Because many players are involved in obesity, the etiology of obesity-related late-onset asthma is not simple and straightforward. |
| PubMedID- 22788947 | Treatment of asthma in obesity needs to consider altered response to controller therapy, and the fact that mechanical factors, metabolic inflammation and other comorbidities are probably contributing to airway disease. |
| PubMedID- 23970905 | There is also some evidence to suggest that obesity may reduce threshold of ahr to potential asthma triggers. |
| PubMedID- 24676351 | Background: obesity has been associated with worse asthma control. |
| PubMedID- 20626634 | Background: most studies regarding the association of obesity with asthma have been performed in the western countries. |
| PubMedID- 25635872 | As both fetal growth and childhood obesity is associated with asthma, further information regarding the associations of peak weight and height velocity with respiratory disorders seems valuable. |
| PubMedID- 21415135 | Background: it is unclear why obesity is associated with worse asthma control. |
| PubMedID- 26487563 | Fifty-five moderate or severe asthmatics with grade ii obesity (bmi ≥ 35 kg/m2) under optimized medication will be randomly assigned into either weight-loss program + sham (wl + s group) or weight-loss program + exercise (wl + e group). |
| PubMedID- 23915208 | asthma is associated with dt2 and obesity [37,38], both of which are metabolic disorders with an underlying systemic inflammatory profile. |
| PubMedID- 25478171 | These mechanisms go on to impact immune and inflammatory responses, muscular and nervous system mechanisms, and hormonal and obesity-related mechanisms, all of which relate to asthma.12–15 studies on asthma prevalence have also attributed some of the disease burden to environmental risk factors, including poor control of pollutants (toxins, dust and mites) in the household.36–42 there is also some evidence on clustering or co-occurrence of risks of disadvantages (socioeconomic, adversity and environmental risks) within households.14364344 studies have, in the past, examined the relationships between stress during pregnancy and postpregnancy and asthma among children.9 the scope for connecting pregnancy and early life exposures to childhood adversity was not available in the brfss surveys, and needs to be investigated in future analyses. |
| PubMedID- 21195942 | Conclusions: obesity was not associated with worse asthma severity, spirometry findings, qol, or hcu in children. |
| PubMedID- 26098111 | The association of obesity with asthma is now well known, with many mouse and human studies confirming this link. |
| PubMedID- 24739266 | Conclusions: overweight and obesity increased the prevalence of symptomatic asthma in adults, especially in women. |
| PubMedID- 23277874 | This retrospective analysis of data obtained from the 4th knhanes, a nationwide survey of south korea in 2008, showed that arthritis, rhinitis, depression and obesity were independently associated with both self-reported ever-asthma and wheezing in adults ≥ 40 years old. |
| PubMedID- 26485533 | We found associations between pre-pregnancy obesity and higher risks of ever asthma and current wheezing at age 7–8 years. |
| PubMedID- 21429056 | With obesity the risk of comorbidity such as asthma, obstructive sleep apnea, hypertension, and diabetes increases. |
| PubMedID- 19844182 | A wealth of epidemiologic literature has established that whereas asthma can lead to obesity, obesity is a risk factor for asthma, but mechanisms are unclear. |
| PubMedID- 20100278 | Background and purpose: obesity is associated with deterioration in asthma outcomes. |
| PubMedID- PMC4407108 | By presenting our two cases we would like put a stress on the variety features inside the group of patients with asthma associated with obesity or overweight. |
| PubMedID- 25342709 | The pathogenesis of late-onset th2-low asthma in obesity is thought to be related to weight-related decreases in lung volume, but why only a subset of individuals with obesity develop this condition is unknown. |