Vitiligo is a chronic auto-immune depigmenting skin disorder that results from a loss of melanocytes. Multiple combinatorial factors have been involved in disease development, with a prominent role of the immune system, in particular T cells. In Sep 16, 2017, Katia Boniface and others published an article in << Journal of Investigative Dermatology >> which title is “Vitiligo skin is imprinted with resident memory CD8 T cells expressing CXCR3”. They sought to perform a thorough characterization of the phenotype and function of skin memory T cells in vitiligo. They show that stable and active vitiligo perilesional skin is enriched with a population of CD8 TRM expressing both CD69 and CD103 compared to psoriasis and control unaffected skin. CD8 TRM expressing CD103 are mainly localized in the epidermis. Remaining CD8 TRM in stable disease could play a role during disease flares, emphasizing the interest to target this cell subset in vitiligo.
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