Vitamin B12 and folate deficiencies are major causes of megaloblastic anemia. Causes of B12 deficiency include pernicious anemia, gastric surgery, intestinal disorders, dietary deficiency, and inherited disorders of B12 transport or absorption. In Mar , 2017, Ralph Green and Ananya Datta Mitrapublished an article in << Medical Clinics of North America >> which title is “Megaloblastic Anemias : Nutritional and Other Causes”. Clinical features of megaloblastic anemia include anemia, cytopenias, jaundice, and megaloblastic marrow morphology. Neurologic symptoms occur in B12 deficiency, but not in folate deficiency.
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