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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine



  Clinical characteristics and outcomes of acquired hemophilia A: experience at a single center in Japan

Acquired hemophilia A (AHA), which is caused by autoantibodies against coagulation factor VIII (FVIII) is a rare, life-threatening bleeding disorder, the incidence of which appears to be increasing in Japan as the population ages. In Mar 15, 2017, Yoshiyuki Ogawa and others published an article in << International Journal of Hematology >> which title is “Clinical characteristics and outcomes of acquired hemophilia A: experience at a single center in Japan”, retrospectively analyzed data from 25 patients (median age 73 years; range 24–92 years; male n = 15) diagnosed with AHA between 1999 and 2015 at Gunma University Hospital. Although most of our patients achieved CR after immunosuppressive therapy, the rate of infection-related mortality was unsatisfactorily high.

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