This article mainly reported that galactose-induced decrease in phosphate levels leads to galactosemia in yeast models. Galactosemia is an inborn error of metabolism caused by deleterious mutations in the GALT gene. Before the evidence, the disease was caused by the galactose-1-phosphate accumulation observed in patient cells, but we still do not know the consequent molecular events. Now this article shows that The decrease in phosphate levels is probably due to the trapping of phosphate in the accumulated galactose-1-phosphate since the deletion of the galactokinase encoding gene GAL1 suppressed this phenotype. Galactose-induced phosphate depletion caused an increase in glycogen content, an expected result since glycogen breakdown by the enzyme glycogen phosphorylase is dependent on inorganic phosphate. These results support new possibilities for the development of better treatments for this disease.
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