eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | wolfram syndrome |
| Comorbidity | C0011860|type 2 diabetes |
| Sentences | 5 |
| PubMedID- 23257691 | Association of rs734312 and rs10010131 polymorphisms in wfs1 gene with type 2 diabetes mellitus: a meta-analysis. |
| PubMedID- 20509872 | Implication of genetic variants near slc30a8, hhex, cdkal1, cdkn2a/b, igf2bp2, fto, tcf2, kcnq1, and wfs1 in type 2 diabetes in a chinese population. |
| PubMedID- 21525464 | wolfram syndrome 1 gene (wfs1) has been associated with type 2 diabetes and with impaired insulin secretion during a glp-1 infusion (62,63), and the variant rs151290 in kcnq1 has been associated with changes in insulin secretion and increased gip and glp-1 secretion (64). |
| PubMedID- 20028947 | We performed a comprehensive fine-mapping and low-frequency variant analysis for wfs1, a locus associated with type 2 diabetes risk (9–11). |
| PubMedID- 21713316 | In contrast, common variants of wfs1 showed association with type 2 diabetes (t2d) in numerous caucasian populations. |
Page: 1