eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | wolfram syndrome |
| Comorbidity | C0011847|diabetes |
| Sentences | 13 |
| PubMedID- 24227685 | Common alleles of wfs1 are associated with increased diabetes risk (45), suggesting that our model of β-cell failure in wolfram syndrome is also relevant to other forms of diabetes. |
| PubMedID- 22737327 | One should consider wolfram syndrome in patients with juvenile onset diabetes mellitus and hearing loss. |
| PubMedID- 21031341 | Sex differences in the development of diabetes in mice with deleted wolframin (wfs1) gene. |
| PubMedID- 24556864 | We should make the best use of these cells to develop treatments for wolfram syndrome—efforts that may lead to breakthroughs in diabetes treatment. |
| PubMedID- 26426397 | Although the connection between loss of function mutations of the wfs1 gene and didmoad-syndrome including diabetes mellitus underpins the significance of wolframin in the pathogenesis, exact role of wfs1 polymorphic variants in the development of type 1 and type 2 diabetes has not been discovered yet. |
| PubMedID- 23903355 | Autosomal dominant diabetes arising from a wolfram syndrome 1 mutation. |
| PubMedID- 21525464 | wolfram syndrome 1 gene (wfs1) has been associated with type 2 diabetes and with impaired insulin secretion during a glp-1 infusion (62,63), and the variant rs151290 in kcnq1 has been associated with changes in insulin secretion and increased gip and glp-1 secretion (64). |
| PubMedID- 20028947 | We also show that low-frequency variants in putative functional regions of wfs1 are not associated with diabetes risk in our u.k. populations. |
| PubMedID- 21713316 | In contrast, common variants of wfs1 showed association with type 2 diabetes (t2d) in numerous caucasian populations. |
| PubMedID- 21447263 | [an evaluation of hla class 2 alleles and anti-islet antibodies as evidence for non-autoimmune diabetes in wolfram syndrome]. |
| PubMedID- 25185852 | The aim of this study was to estimate the prevalence of wolfram syndrome among children with diabetes in poland. |
| PubMedID- 23257691 | Association of rs734312 and rs10010131 polymorphisms in wfs1 gene with type 2 diabetes mellitus: a meta-analysis. |
| PubMedID- 24477584 | The rs734312 from wfs1 gene was associated with diabetes at genotype level (p<0.01). |
Page: 1