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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease wernicke-korsakoff syndrome
Comorbidity C0039841|thiamine deficiency
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PubMedID- 25446352 Using the pyrithiamine-induced thiamine deficiency (ptd) rat model of human wernicke-korsakoff syndrome, we tested the hypothesis that co-infusion of the acetylcholinesterase inhibitor physostigmine across the pfc and hpc would recover spatial alternation performance in ptd rats.
PubMedID- 25695433 thiamine deficiency is associated with wernicke-korsakoff syndrome, alzheimer’s disease, amyotrophic lateral sclerosis, parkinson’s disease, multiple sclerosis and diabetes [16,17], which are treated with effectiveness with thiamine or its derivatives.

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