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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease thrombophilia
Comorbidity C0027726|nephrotic syndrome
Sentences 5
PubMedID- 24067475 The hypercoagulability of patients with nephrotic syndrome could be an important trigger for arterial and venous thrombotic events.
PubMedID- 21917124 hypercoagulable state associated with nephrotic syndrome and antiphospholipid syndrome can lead to the development of occlusive coronary artery thrombus in absence of atherosclerotic coronary artery disease.
PubMedID- 25984105 In fact, despite the underlying causes of the hypercoagulable state in patients with nephrotic syndrome that are not well understood, a variety of haemostatic abnormalities have been described, including decreased levels of antithrombin and plasminogen (due to urinary losses), increased platelet activation, hyperfibrinogenaemia, inhibition of plasminogen activation, and the presence of high-molecular-weight fibrinogen moieties in the circulation [11].
PubMedID- 25607275 nephrotic syndrome is associated with a hypercoagulable state and an increased risk of thromboembolic complications.
PubMedID- 26168694 Mechanisms of hypercoagulability in nephrotic syndrome associated with membranous nephropathy as assessed by thromboelastography.

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