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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease thrombocytopenia
Comorbidity C0020532|hypersplenism
Sentences 11
PubMedID- 22287875 hypersplenism as a cause of thrombocytopenia may reflect portal hypertension from cirrhosis, collagen vascular disease, or rarely primary neoplasm of the spleen.
PubMedID- 20467465 Primary indications for psss were repeated variceal bleeding despite endoscopic therapy (6), symptomatic hypersplenism with thrombocytopenia (2), and liver dysfunction in the setting of hepatic vein thrombosis (2).
PubMedID- 22057175 A splenectomy was done due to persistent thrombocytopenia associated with hypersplenism, with good response of the platelets counts.
PubMedID- 23901200 hypersplenism may lead to thrombocytopenia, who may present with bleeding similar to our case.
PubMedID- 24255616 Lower values ofplatelet counts are seen especially in patients with hs after gastrointestinal bleeding.this was also seen in the current work with the possible cause being the increase ofspleen and hypersplenism leading to frequent thrombocytopenia, leukopenia and anemia.
PubMedID- 25233685 Indications for surgery were pain and abdominal discomfort caused by spleen enlargement, as well as symptomatic hypersplenism with leucopenia, thrombocytopenia and anemia.
PubMedID- 21734807 Aim: to study the safety and feasibility of total embolization of the main splenic artery as a supplemental treatment modality for hypersplenism with thrombocytopenia or leukocytopenia accompanying liver cirrhosis.
PubMedID- 22985446 Introduction: hypersplenism with thrombocytopenia is a common complication of cirrhosis with portal hypertension.
PubMedID- 22708981 Peripheral platelet destruction or sequestration is the major mechanism for thrombocytopenia, with hypersplenism being an important cause.
PubMedID- 23420139 While in some patients the disease remained static, in a larger proportion a more severe disease developed characterized by portal hypertension, the latter leading to hypersplenism with neutropenia and thrombocytopenia and, in some cases, to ascites.
PubMedID- 23132324 The indications for surgery were pain and discomfort caused by a large spleen (5-15 cm below the costal margin) and symptomatic hypersplenism with leucopenia, thrombocytopenia, and anemia.

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