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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease thrombocytopenia
Comorbidity C0002871|anemia
Sentences 64
PubMedID- 25057402 Furthermore, reports of haemolytic anemia in conjunction with thrombocytopenia raise the possibility of oxaliplatin-induced microangiopathy.
PubMedID- 26511208 A complete blood count revealed bicytopenia (normocytic-normochromic anemia with thrombocytopenia).
PubMedID- 21377915 A 79 year-old man was referred to the hematology unit of a hospital because of anemia with thrombocytopenia and hepatosplenomegaly.
PubMedID- 25434823 The symptoms range from mild cytopenia in any lineage to severe aplastic anemia, often initially with thrombocytopenia (shimamura and alter, 2010).
PubMedID- 23842487 Background: hemolytic anemia with thrombocytopenia and schistocytosis is suggestive of thrombotic thrombocytopenic purpura (ttp).
PubMedID- 25345959 The most common clinical characteristics were bone pain (65%), anemia with thrombocytopenia (63.6%) and leukoerythroblastic reaction (61%).
PubMedID- 25075486 A higher risk of thrombocytopenia was identified in patients with severe anemia, neurologic complications, pulmonary complications, liver dysfunction, renal impairment and severe hypoglycemia.
PubMedID- 20589460 In addition to anemia, occurrence of neutropenia and/or thrombocytopenia is increasingly being reported.
PubMedID- 20359326 This disease causes hemolytic anemia with fragmentation of erythrocytes, thrombocytopenia, diffuse and nonfocal neurologic findings, and decreased renal function.
PubMedID- 21776377 Sle patients having thrombocytopenia in complication with anemia should be considered a monitoring of adamts-13 activity even though the patients lacked symptoms of ttp related to the microvascular coagulation.
PubMedID- 22606437 Laboratory tests revealed anemia with a hematocrit of 37%, severe thrombocytopenia with 44000 platelets, coagulopathy with a prolonged prothrombin time of 20.3 seconds and elevated liver tests with total bilirubin of 4 mg/dl, ast of 59 international units, alt of 36 international units, and elevated alkaline phosphatase of 182. autoimmune workup was negative, alpha-1-antitrypsin and serum ceruloplasmin levels were within normal limits and 24-hour urine copper was above the normal limit.
PubMedID- 20413929 [2] severe anemia, when associated with thrombocytopenia can frequently result in ocular manifestations.
PubMedID- 24587907 Bicytopenia (anemia with thrombocytopaenia) was seen in 13 (52%) of patients.
PubMedID- 20056203 Result(s): both patients developed a very rare complication after surgery of severe thrombocytopenia with microangiopathic hemolytic anemia leading to acute renal failure.
PubMedID- 24490094 There are many reported cases of hemolytic anemia with or without thrombocytopenia in gastric cancer.
PubMedID- 24649446 The common co-morbid diseases at the onset of seizures were hematological disorders (pancytopenia 8, anemia 2, anemia with thrombocytopenia 2) and sepsis (n=8).
PubMedID- 24106450 Normochromic-normocytic anemia ormacrocytic anemia with thrombocytopenia may occur.
PubMedID- 20399168 Hemolytic anemia with schistocytes, thrombocytopenia without evidence of disseminated intravascular coagulation, and renal failure are consistently found.
PubMedID- 23559773 Laboratory investigations showed anemia with hemoglobin of 4.7 gm% and thrombocytopenia with a platelet count of 29,000/cumm.
PubMedID- 22567017 Laboratory examination was remarkable for anemia (hemoglobin of 5.8 mg/dl) and thrombocytopenia (platelets less than 10,000/mm3) with lactate dehydrogenase of 744 u/l.
PubMedID- 20418784 A univariate analysis of the variables, age <2 years, lungs, spleen and hepatic involvement, presence of >or=2 risk involved organs, hypoalbuminemia and the presence of isolated anemia, anemia with thrombocytopenia with or without leukopenia at diagnosis was performed.
PubMedID- 23989401 For thrombotic thrombocytopenic purpura and hemolytic uremic syndrome (ttp-hus) the diagnosis of coombs negative hemolytic anemia together with thrombocytopenia should lead to the detection of fragmentocytes in peripheral blood smears.
PubMedID- 24363883 In advanced cll, isolated thrombocytopenia without anemia is more likely to have autoimmune etiology.33,34,42 because thrombocytopenia commonly seen with infections such as hepatitis c, helicobacter pylori and human immunodeficiency virus, it is prudent to investigate for these infections, and sometimes management of these infections may increase platelet counts without using corticosteroids43 (table 3).
PubMedID- 24413066 thrombocytopenia with coexistent anemia was found in just one case (4%), splenomegaly in two (8%) and lymphadenopathy also in only one (4%).
PubMedID- 22929300 59. thrombocytopenia associated with mechanical hemolytic anemia should suggest tma, even in the absence of organ failure (strong agreement).
PubMedID- 21332348 Thrombotic thrombocytopenic purpura (ttp)/hemolytic uremic syndrome (hus) is characterized with fever, purpura, anemia due to microangiopathic hemolysis, thrombocytopenia, kidney damage, and neurologic symptoms.
PubMedID- 21425920 Predominant features of perinatal onset mevalonate kinase deficiency include intrauterine growth restriction, cerebral ventriculomegaly, dysmorphic features, skeletal abnormalities, dyserythropoietic anemia with extramedullary erythropoiesis, thrombocytopenia, cholestatic liver disease, persistent diarrhea, renal failure, recurrent sepsis-like episodes, and failure to thrive.
PubMedID- 24013519 A mixed-type autoimmune hemolytic anemia with immune thrombocytopenia related with myositis and post-transplantation lymphoproliferative disorder.
PubMedID- 20436664 Thrombotic microangiopathies (tma) represent a rare and heterogeneous group of diseases defined by microangiopathic hemolytic anemia with peripheral thrombocytopenia and organ failure of variable severity.
PubMedID- 21597288 Grade 3 and 4 toxicities included anemia (20.5% of patients), thrombocytopenia (2.3%), neutropenia (10.3%), aspartate transaminase increase (10.3%), alanine transaminase increase (5.1%) and emesis (5.1%).
PubMedID- 24719674 Her laboratory profile (6 months prior to admission) revealed anemia with hemoglobin of 11.4 g/dl and thrombocytopenia, with a platelet count of 87×103/ul.
PubMedID- 23943710 A congenital or acquired deficiency of adamts-13 can result in accumulation of the ultralarge vwf multimers leading to microangiopathic thromboses and severe thrombocytopenia with resultant hemolytic anemia and thrombotic sequelae.6 in the rare familial forms of ttp, mutations of the adamts-13 gene can be found resulting in significant risk of ttp in pregnancy in affected women.6 acquired ttp is postulated to be secondary to viral infections that trigger production of antibodies targeted against adamts-13.7 women with acquired ttp also have a high risk of recurrence in a subsequent pregnancy.6 it has been proposed that specific proteins found in the placental circulation serve as antigens that trigger maternal antibody production against adamts-13.
PubMedID- 21772952 Evans syndrome (es) is an autoimmune disorder characterized by thrombocytopenia and/or neutropenia associated with hemolytic anemia (aha).1–3 it is a potentially life-threatening condition that may be associated with other underlying autoimmune or lymph-proliferative disorders.4 standard treatment consists of transfusions, corticosteroids and immunoglobulins (ivig); second-line treatment in es evolved over the last decade, and includes at present anti-cd20 rituximab, vincristine, alkalizing agents, mycophenolate mofetil (mmf) or cyclosporine (cya).5–6,8–14 long-term remissions induced by splenectomy are less frequent than in uncomplicated immune thrombocytopenia purpura (itp).
PubMedID- 23827373 Hemolytic and uremic syndrome (hus) is a classical form of thrombotic microangiopathies characterized by the association of hemolytic anemia with schizocytes, thrombocytopenia, and acute renal failure.
PubMedID- 24833969 [40] found a non-regenerative anemia, with neutropenia, thrombocytopenia and normallymphocyte count.
PubMedID- 22953078 The initial laboratory testing carried out in front of this mechanical anemia with thrombocytopenia unresponsive to transfusions showed an increased ldh 863 ui/l (2 times normal), serum potassium to 4.2 mmol/l (3–5 mmol/l), collapsed serum haptoglobin (0.53 g/l), hyperbilirubinemia (25 mg/l), the direct coombs test (the test in antiglobinul) negative, proteinuria 900 mg/24 h, and renal function normal with serum creatinine at 5 mg/l (7–14 mg/l).
PubMedID- 23961497 The overall impression on hematological examination was hemolytic anemia with thrombocytopenia and reactive marrow hyperplasia.
PubMedID- 24800022 Three patients with cholelithiasis died, one because of end stage renal disease due to polycystic kidney disease (pkd), one because of renal failure and hemorrhage complicating thrombocytopenia associated with fanconi anemia, and the last one because of metabolic disease (mitochondrial type).
PubMedID- 21295897 We report the first case to our knowledge of a patient who developed an acute decrease in kidney function, nonimmune microangiopathic hemolytic anemia with schistocytes, and thrombocytopenia after 4 intravitreal injections of ranibizumab.
PubMedID- 19802631 Investigations revealed anemia (hemoglobin of 8.9 g/dl), thrombocytopenia (platelet count of 21,000 cells per microliter), and positive hiv antibody (perinatal transmission).
PubMedID- 22760926 This resulted in a partial response 3 months later: persistent transfusion-dependent anemia without signs of intravascular hemolysis, thrombocytopenia, and a normal leucocyte count.
PubMedID- 25821808 Eryptosis is triggered by hemolytic uremic syndrome (hus), characterized by hemolytic anemia with fragmented erythrocytes, thrombocytopenia, and acute renal failure [198].
PubMedID- 21779188 Characteristic laboratory findings of ca-maha are anemia with schistocytes, thrombocytopenia, leukoerythroblastic anemia, decreased haptoglobin levels, and elevated serum levels of alp, ldh, and bilirubin [2, 10, 12].
PubMedID- 25816809 Ahus was suspected based on anemia with schistocytes, thrombocytopenia, low c3, and acute kidney injury requiring peritoneal dialysis.
PubMedID- 22493563 Profound degree of iron deficiency anemia can present with thrombocytopenia and severe menorrhagia.
PubMedID- 21151638 [8] reported a case of thrombocytopenia associated with hemolytic anemia in a patient with intracardiac metastasis originating from a testicular teratoma.
PubMedID- 21694933 The patient exhibited anemia with hemoglobin level of 7.9 g/dl, thrombocytopenia (platelet count of 140000/mm3), renal insuff iciency (creatinine clearance: 38 ml/min/1.73 m2) and hypertension (120/80 mmhg).
PubMedID- 22001463 A case of anemia with schistocytosis, thrombocytopenia, and acute renal failure caused by adenomyosis.
PubMedID- 26000153 Furthermore, on this occasion microcytic anemia with hyposideremia and thrombocytopenia (121,000/mm3) were also demonstrated in addition to leukopenia.
PubMedID- 22570800 Hematological abnormalities such as chronic disease anemia, leucopenia with lymphopenia, thrombocytopenia or, more rarely, pancytopenia, are frequently described [6].

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