eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | thalassemia |
| Comorbidity | C0029456|osteoporosis |
| Sentences | 9 |
| PubMedID- 25216685 | Iron overload causes osteoporosis in thalassemia major patients through interaction with transient receptor potential vanilloid type 1 (trpv1) channels. |
| PubMedID- 25849944 | The reported frequency of osteoporosis, in thalassemia mayor patients, despite adequate transfusion and iron chelation therapy, varies from 13.6% to 50% with an additional 45% affected by osteopenia [67]. |
| PubMedID- 20976089 | The pathogenesis of osteoporosis in thalassaemia major (tm) is complicated and differs from the pathogenesis of bone deformities characteristically found in nontransfused patients who develop bone distortion mainly due to ineffective haemopoiesis and progressive marrow expansion [3]. |
| PubMedID- 22778734 | Subjects in low pubertal staging and short stature(<3% percentile) have significantly lower bone mass densities p < 0.001. conclusion.he prevalence of osteoporosis is high in patients with thalassemia major, possibly related to delayed puberty. |
| PubMedID- 24575552 | osteoporosis in thalassemia major: an update and the i-cet 2013 recommendations for surveillance and treatment. |
| PubMedID- 22581647 | We conclude that circulating sclerostin is elevated in thalassemia patients with osteoporosis and correlated with their bmd, but it was not reduced post zoledronic acid administration. |
| PubMedID- 22966867 | Prospective study of histomorphometry, biochemical bone markers and bone densitometric response to pamidronate in beta-thalassaemia presenting with osteopenia-osteoporosis syndrome. |
| PubMedID- 20694183 | In a study by otrock et al,60 18 thalassemia patients with osteoporosis were given zol 4 mg iv every 3 months over a period of 12 months. |
| PubMedID- 25002928 | Haticehamarat, et al studied frequency of osteoporosis in thalassemia major patients in turkey and showed that among25 patients with thalassemia major (14 men, 11 women) 16 patients had osteoporosis, where as 9 patients had osteopenia (18). |
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