eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | thalassemia |
| Comorbidity | C0011847|diabetes |
| Sentences | 9 |
| PubMedID- 26023548 | The prevalence of diabetes in patients with thalassemia varies from 6 to 14%. |
| PubMedID- 25722965 | The prevalence of diabetes in alfathalassaemia was 1.3 percent which was considerably lower than the previous our pervious study on beta thalassaemia, 8.5% [9]. |
| PubMedID- 25236606 | Besides iron accumulation fatty degeneration might be an additional risk factor for the development of diabetes in beta-thalassemia major, but this hypothesis needs further studies in prediabetic patients. |
| PubMedID- 20492708 | Since treatment of diabetes in patients with thalassemia major is an additional burden, support from doctors and psychologists is needed. |
| PubMedID- 24111905 | Cardiac complications and diabetes in thalassaemia major: a large historical multicentre study. |
| PubMedID- 20398341 | The etiology of diabetes in β-thalassemia is increased peripheral resistance to insulin and direct toxic effect of excess iron in the acinar and beta cells of pancreas resulting in insulin deficiency [5]. |
| PubMedID- 25710019 | thalassemia major patients with diabetes mellitus had a higher risk of cardiac complications, including heart failure, hyperkinetic arrhythmias, and myocardial fibrosis [93]. |
| PubMedID- 24115521 | diabetes mellitus in patients with thalassemia major. |
| PubMedID- 25834825 | The development of diabetes in thalassemia is attributed to impaired insulin excretory function secondary to chronic iron overload in the pancreas [45], selective immune system activation against pancreatic β-cells leading to cell damage [46], and/or pancreatic cell death due to fat transformation [47]. |
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