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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease small cell carcinoma
Comorbidity C0007131|nsclc
Sentences 7
PubMedID- 21595568 Context: nonsmall cell lung cancers with neuroendocrine differentiation (nsclc-nd) may demonstrate biologic behavior intermediate between nsclc and small cell lung cancer (sclc) with impact on prognosis.
PubMedID- 23077446 Found significantly lower adc values for sclc when comparing with nsclc groups in a similar patient population.26 liu et al.
PubMedID- 23420619 There are few treatment options in second-line chemotherapy for sclc treatment compared with nsclc treatment, and further biological research of sclc is required to identify pathways that may be targeted with new antitumor drugs.
PubMedID- 22700587 In contrast, retinoic acid receptor-γ, thyroid hormone receptor-β and vitamin d receptor (vdr) showed moderately or dramatically reduced expression in sclc compared with the nsclc or hbec (fig.
PubMedID- 20624269 These results support the hypothesis that differential expression of mirnas could contribute to the differentiation of lung cancer cells from one subtype to another, in which sclc could result from nsclc cells by gradually acquiring sclc properties through the cumulative dysregulation of mirnas, and that manipulating the levels of specific mirnas levels might prevent the differentiation of lung cancer cells toward a more malignant phenotype.
PubMedID- 24204697 Similarly, in contrast to nsclc, growth of small cell lung cancer cells (sclc) is driven through the establishment of neuropeptide autocrine loops [43].
PubMedID- 23244181 It is classified into non-small cell lung cancer (nsclc) representing 70-80% of cases and small cell lung cancer (sclc) which has neuroendocrine properties with poor outcome.

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