eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | sclerosteosis |
| Comorbidity | C0029454|osteopetrosis |
| Sentences | 1 |
| PubMedID- 26456319 | Activation of notch1 in osteocytes of rosanotch mice, where a loxp-flanked stop cassette and the nicd coding sequence were targeted to the reverse orientation splice acceptor (rosa)26 locus, causes osteopetrosis associated with suppressed sost expression and enhanced wnt signaling. |
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