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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease sarcoidosis
Comorbidity C0020437|hypercalcemia
Sentences 5
PubMedID- 21209801 The mechanism of hypercalcemia in sarcoidosis is not completely understood.
PubMedID- 24663253 hypercalcemia in sarcoidosis is due to three mechanistic reasons: (1) systemic conversion of 25-hydroxyvitamin d to 1,25-dihydroxyvitamin d by the enzyme 1-alpha hydroxylase produced by activated monocyte/macrophage system, (2) production of parathormone-related peptide (pthrp) by the sarcoid granuloma, (3) tissue-level conversion of 25-hydroxyvitamin d to 1,25-dihydroxyvitamin d by 1-alphahydroxylase produced by local monocyte/macrophage system in the sarcoid granuloma.
PubMedID- 26029574 Although the emc and sarcoidosis with associated hypercalcemia may have been coincidental in our case, the fact that both lymphadenopathy and hypercalcemia resolved after resection of the primary tumor suggests a more intimate relationship.
PubMedID- 24753153 Overproduction of 1alpha-hydroxylase is held responsible for the development of hypercalcemia in sarcoidosis patients.
PubMedID- 24246340 Objective: to report an uncommon cause of 1,25-dihydroxyvitamin d (1,25[oh]2d)-mediated hypercalcemia associated with splenic sarcoidosis and illustrate the evaluation and potential role of fluorodeoxyglucose (fdg) positron emission tomography (pet)/computed tomography (ct) in such patients.

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