Home Contact Sitemap

eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease sandhoff disease
Comorbidity C0028754|obesity
Sentences 19
PubMedID- 24289790 The fact that the majority of studies has failed to associate the fto variants with obesity related trait, indicates that this gene is in a very close relationship with obesity and fat mass.
PubMedID- 24102053 The data were further analyzed for gender differences; fto variant associated significantly with obesity (p < 0.01, 95% ci = 1.6–9.2) only in adult females (>18 years old).
PubMedID- 23921993 First, we investigated the association of the fto variant with risk of obesity in a case/control analysis of all overweight/obese samples (n=10 538) versus normal weight controls (n=4598) irrespective of oa status and found that to be highly significant.
PubMedID- 21150882 Although the sample size was modest, our study strongly replicated the association of fto variants with obesity-related measures and tcf7l2 variants with t2d-related traits.
PubMedID- 20092643 Interestingly, we observed that the obesity risk allele a of the fto variant rs9939609 was less frequently observed in patients with polycystic ovarian morphology (pco) compared to pcos patients without pco (or = 0.57, 95%, ci 0.36;0.88, p-value = 0.01) and even after correction for bmi this relationship was still present (or = 0.60, 95%ci 0.37;0.93, p-value = 0.02).
PubMedID- 20044928 However, in the population-based study we observed no evidence for an association of the two variants with adult obesity (all p ≥ 0.05; table 4) or bmi (see methods).
PubMedID- 20858286 In contrast, the first study of the association between fto and bmi among chinese population in mainland china [15] found no association of fto variants with obesity and bmi in the chinese adults aged 50-70 years living in beijing and shanghai.
PubMedID- 20299471 This finding is significant because, to date, the focus on fto variants associated with obesity has been, for the most part, on the specific snps or other intron 1 snps reported in the initial genome-wide association study.
PubMedID- 26357660 All fto variants were associated with obesity, and some biochemical and anthropometric measures and had higher minor allele frequencies than those reported for asian populations previously.
PubMedID- 25177340 Fto variants not associated with obesity demonstrated other potential disease associations including non-inflammatory disorders of the cervix and chronic periodontitis.
PubMedID- 25542809 The aim of this study was to investigate whether fto variants are associated with obesity in thais.
PubMedID- 21118518 We demonstrate the ability to replicate in our population the association of fto variants with obesity, which is the main bmi-associated locus, thus further proving the robustness of the association and the appropriate selection of our samples to study obesity.
PubMedID- 21989907 This study provides the first report of allele and genotype frequencies for the rs9939609 polymorphism and also the first evidence of the association of the fto variant with obesity in the roma/gypsy population.
PubMedID- 22153534 Conclusion: the obesity-linked fto variants do not play a significant role in modulating the colorectal cancer risk in the italian population.
PubMedID- 23091647 Conclusion: the study provides first report of association of fto variants with obesity and related anthropometric traits in indian children with higher impact in children compared to adults.
PubMedID- 24278475 Subsequently, the association of fto variants with bmi and obesity has been investigated in different ethnic populations.
PubMedID- 23963770 Objective: to investigate the magnitude of association of fto variants with obesity, type 2 diabetes (t2dm), and related traits among asian indians.
PubMedID- 25809737 Objectives: to investigate in a population sample of portuguese young adults the association of the fto variant rs9939609 with obesity, bmi, and body-fat and interaction with physical activity (pa) on obesity-susceptibility.
PubMedID- 22675562 Recent studies suggest that fto variants strongly correlate with obesity and mainly influence energy intake with little effect on the basal metabolic rate.

Page: 1