eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | rheumatoid arthritis |
| Comorbidity | C0006625|cachexia |
| Sentences | 7 |
| PubMedID- 20953376 | It has to be noted that severe rheumatoid disease is associated with inflammatory cachexia characterized by the loss of lean body tissue that is often compensated for by gain in body fat. |
| PubMedID- 23515620 | Rheumatoid cachexia is associated with rheumatoid arthritis and it increases mortality and morbidity. |
| PubMedID- 21345206 | The results of trials evaluating the effect of hmβ supplementation on reversing cachexia associated with rheumatoid arthritis [14], hiv [8], and muscle damage [15,16] are performed merely with biochemical markers. |
| PubMedID- 22096370 | Introduction: cachexia is associated with rheumatoid arthritis (ra), but whether it is attributable primarily to reduced dietary intake or increased metabolism is unclear, as is the association with inflammation. |
| PubMedID- 26233497 | Does rheumatoid cachexia predispose patients with rheumatoid arthritis to osteoporosis and vertebral fractures. |
| PubMedID- 21876977 | Rheumatoid cachexia affects two-thirds of rheumatoid arthritis (ra) patients and is defined as the loss of body cell mass (bcm), which is the fat-free component of cells within muscle, visceral organs and the immune system, and an often compensatory increase in fat mass (fm; i.e., cachectic obesity).1 bcm is considered to be the most important factor in determining energy expenditure, protein needs, and the metabolic response to stress.2 the consequences of chronic inflammation and increased production of cytokines, including tumor necrosis factor (tnf)-α and interleukin (il)-1β, are responsible for higher resting energy turnovers and altered body compositions in ra patients.3 sir james paget described wasting of skeletal muscle mass in patients with inflammatory arthritis that was not due to disuse atrophy.4 the loss of bcm in various diseases, including ra, congestive heart failure, acquired immunodeficiency syndrome (aids), starvation, critical illness, and aging has been associated with poor clinical outcomes.5 rheumatoid cachexia is associated with an increased erythrocyte sedimentation rate (esr), c-reactive protein (crp), functional dependence, and an increased chance of morbidity and premature mortality.6 although the prevalence rate of rheumatoid cachexia is high, it remains under-recognized, partly because an abnormal body composition phenotype in ra patients occurs most often in patients with normal body mass indexes (bmis).1,3, therefore, a body composition measurement beyond anthropometric parameters is essential to identifying ra patients with rheumatoid cachexia. |
| PubMedID- 20633016 | Conclusions and implications: our animal model induced a severe inflammatory cachexia, comparable to that of persistently active rheumatoid arthritis. |
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