eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | progressive multifocal leukoencephalopathy |
| Comorbidity | C0042769|virus infection |
| Sentences | 2 |
| PubMedID- 24790453 | There have been a few reports of john cunningham (jc) virus infection leading to progressive multifocal leukoencephalopathy following rituximab, although these cases have involved patients exposed to significant immunosuppression over a period of time.92 the other long-term complication ascribed to rituximab is hypogammaglobulinemia, which again seems to be related to cumulative exposure to immunosuppression.93 there is an obligation therefore to try to avoid excessive immunosuppression, even in patients at risk of relapse, and means to better predict relapse are urgently required. |
| PubMedID- 24763718 | Jc virus infection can lead to progressive multifocal leukoencephalopathy in individuals with a compromised immune system, such as during hiv infections or when treated with immunosuppressive or immunomodulating therapies. |
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