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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease progressive multifocal leukoencephalopathy
Comorbidity C0010346|crohn\'s disease
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PubMedID- 20565845 Due to detailed brain autopsies, natalizumab, a novel antibody directed to the adhesion molecule a4 integrin, was identified as a risk factor for development of progressive multifocal leukoencephalopathy in patients with crohn's disease or multiple sclerosis treated with this drug [28].
PubMedID- 23232602 Objective: natalizumab, a highly effective treatment for multiple sclerosis (ms) and crohn's disease, is associated with progressive multifocal leukoencephalopathy (pml).
PubMedID- 20594122 There have been reports of progressive multifocal leukoencephalopathy after treatment with natalizumab in crohn's disease and multiple sclerosis.

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