eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | precocious puberty |
| Comorbidity | C0020676|hypothyroidism |
| Sentences | 5 |
| PubMedID- 23901203 | The clinical syndrome of severe primary hypothyroidism associated with isosexual precocious puberty in females was first described by kendle in 1905. |
| PubMedID- 24251145 | Van wyk and grumbach first reported multicystic ovaries with precocious puberty in patients with hypothyroidism in 1960. |
| PubMedID- 21966653 | The salient diagnostic features include long-standing hypothyroidism,[23] high levels of tsh,[4] isosexual precocity with lack of public and axillary hair growth, and delayed bone age. |
| PubMedID- 23329774 | Van wyk-grumbach syndrome is a rare disease characterized by precocious puberty associated with prolonged hypothyroidism and multicystic enlarged ovaries. |
| PubMedID- 24118058 | Conclusion: pituitary hyperplasia secondary to primary hypothyroidism girls with sexual precocity have increased plasma tsh, fsh, prl, e2 and t levels, pituitary height and uterine, ovarian and follicular size. |
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