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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease pre-eclampsia
Comorbidity C0020538|hypertension
Sentences 40
PubMedID- 21858206 Our current knowledge is that hypertension in preeclampsia is secondary to placental underperfusion.
PubMedID- 23118594 There is a higher risk of maternal morbidity, including arterial hypertension leading to preeclampsia or eclampsia, suicide attempts and post partum depression.
PubMedID- 24910806 However, aortic dissection is very rare in young females and in association with severe hypertension due to preeclampsia, coarctation of the aorta or connective tissue disorders as marfan syndrome, congenital heart disease, trauma and inflammatory diseases (3), but our patient had no obvious predisposing factor for aortic dissection.
PubMedID- 24159378 hypertension in preeclampsia is associated with placental ischemia-induced release of antiangiogenic soluble fms-like tyrosine kinase (sflt-1) into the maternal circulation, which antagonizes vascular endothelial growth factor (vegf) promoting endothelial dysfunction.
PubMedID- 21531374 The genetic deletion of catechol o-methyltransferase (comt) in mice produces a preeclampsia-like phenotype, with mice exhibiting hypertension, proteinuria, and histological changes, consistent with human pathological features.
PubMedID- 26000015 Captopril can be used safely and effectively in managing postpartum hypertension in women with severe preeclampsia [31].
PubMedID- 20174514 Various complications implicated in these studies were bleeding during pregnancy, abruption, hypertension and the use of diuretics, preeclampsia, and polyhydraminos.
PubMedID- 23404257 Maternal benefits include improved cardiovascular function, minimal weight gain during pregnancy, decreased musculoskeletal discomfort and mood stability, reduction of gdm and gestational hypertension that may lead to preeclampsia (pe).
PubMedID- 23545163 Objective: preeclampsia (pe) is associated with hypertension and elevated endothelin (et-1), an indicator of endothelial cell activation and dysfunction.
PubMedID- 25330689 Conclusion: in our cohort most women with chronic hypertension were diagnosed with superimposed preeclampsia based on exacerbation in blood pressure and/or new-onset or increase in proteinuria.
PubMedID- 25448508 Objective: we sought to compare maternal and neonatal outcomes of expectantly managed pregnancies complicated by chronic hypertension with superimposed preeclampsia vs mild preeclampsia up to 37 weeks of gestation.
PubMedID- 26366935 It is controversial that uric acid (ua) levels are related to the severity of hypertension in preeclampsia (pe).
PubMedID- 22838249 During expectant management 6 patients displayed hypertension with proteinuria, representing preeclampsia, by the 2nd trimester (11-24 weeks) and the other 9 did not (nonpreeclamptic).
PubMedID- 21146124 In this article, we review current understanding of the mechanisms of vegf-targeted therapy-induced hypertension, discuss similarities with preeclampsia, review implications for therapy of this increasingly common clinical problem, and discuss the potential use of blood pressure increase as a biomarker for proper drug dosing and effective vegf pathway inhibition.
PubMedID- 20385595 Placental overproduction of sflt1 may contribute to the syndrome of preeclampsia with proteinuria and hypertension since recombinant sflt1 induces proteinuria in pregnant and non-pregnant rodents (6–8).
PubMedID- 22380763 Results: there were statistically significant differences between the groups when comparing severe preeclampsia with chronic hypertension, and severe preeclampsia with the control group (p < 0.0001).
PubMedID- 24910751 Gestational hypertension, diabetes), history of abortion, preeclampsia, multigravity and multiple pregnancies.
PubMedID- 23850528 The joint association of perceived stress during pregnancy and chronic hypertension with preeclampsia was very similar to that of the joint association of lifetime stress and chronic hypertension with preeclampsia.
PubMedID- 20513456 The non-treated pathology is associated with higher risk of maternal morbidity, including arterial hypertension, which could lead to preeclampsia or eclampsia, ideation and suicide attempts, and postpartum depression.
PubMedID- 25995814 preeclampsia is characterized with hypertension and proteinuria during pregnancy, and can have serious consequences about maternal and fetal health.
PubMedID- 21480159 The association of hypertension with preeclampsia was expected.
PubMedID- 24854625 The risk for preeclampsia increased 12-fold with gestational hypertension (p=0.003) and 14-fold with combined chronic and gestational hypertension (p=0.001).
PubMedID- 23732498 hypertension in preeclampsia is an epiphenomenon which needs to be controlled at levels that reduce maternal risk without impairing placental perfusion.
PubMedID- 20399167 hypertension occurs in 6-8% of pregnancies, preeclampsia in 2%, found to be "severe" in 0.6%.
PubMedID- 21966796 The most common mother complication was type renovascular hypertension with added severe preeclampsia, which determined the presence of intrauterine growth restriction.
PubMedID- 23657513 Results: there were significant differences between the groups in comparing severe preeclampsia with chronic hypertension and severe preeclampsia with controls (p < 0.0001 for both measurements).
PubMedID- 23485144 hypertension in preeclampsia appears to be triggered by a placental factor, which leads to endothelial activation/dysfunction.
PubMedID- 23817797 preeclampsia is associated with hypertension and increased infant and maternal morbidity and mortality.
PubMedID- 24881356 The progression of gestational hypertension in preeclampsia was more common in preterm pregnancy.
PubMedID- 24551572 preeclampsia is manifested with hypertension, proteinuria, and edema.
PubMedID- 26391409 preeclampsia in combination with preexisting hypertension conferred a significant nearly 6-fold risk in comparison with a 4-fold risk for preexisting hypertension alone.
PubMedID- 24733364 In the nchs multiple birth database, it is impossible to distinguish between gestational hypertension (without proteinuria) and preeclampsia (gestational hypertension with proteinuria).
PubMedID- 24130940 30 mmhg or higher increase in systolic blood pressure and 15 mmhg or higher increase in diastolic blood pressure over the baseline values and doubling proteinuria was defined as superimposed preeclampsia in those with hypertension and proteinuria >300 mg/day.
PubMedID- 25614387 Moreover, the risk of developing hypertension in women with preeclampsia was higher 2 years postpartum than in women without preeclampsia.
PubMedID- 22105295 514: emergent therapy for acute-onset, severe hypertension with preeclampsia or eclampsia.
PubMedID- 25016896 13 patients had s/d ratio greater than 2.6, of which 5 had gestational hypertension, 3 with preeclampsia, 1 with fetal growth restriction, 4 with normal pregnancy.
PubMedID- 23671584 Risk factors of superimposed preeclampsia in women with essential chronic hypertension treated before pregnancy.
PubMedID- 24958504 Analysis of urinary markers revealed higher excretion of albumin and kidney injury molecule-1 and lower excretion of neutrophil gelatinase-associated lipocalin and epithelial growth factor in severe preeclampsia compared with chronic hypertension and healthy controls.
PubMedID- 20948996 It is possible that difficulty in determining the clinical diagnosis of preeclampsia in subjects with chronic hypertension and especially these and other subjects with preexisting proteinuria may have affected the results of this study.
PubMedID- 23793484 Icd-9 hospital discharge diagnosis codes were used to assign hypertensive disorders hierarchically as chronic hypertension, chronic hypertension with superimposed preeclampsia, preeclampsia (eclampsia/severe or mild), or gestational hypertension.

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