eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | portal hypertension |
| Comorbidity | C0020532|hypersplenism |
| Sentences | 15 |
| PubMedID- 23454561 | The incidence of hypersplenism in patients with cirrhosis and portal hypertension is high. |
| PubMedID- 20961440 | Life-threatening hypersplenism due to idiopathic portal hypertension in early childhood: case report and review of the literature. |
| PubMedID- 23275773 | The second etiology is much more common and is related to hypersplenism due to portal hypertension as a result of oxaliplatin-induced hepatic sinusoidal injury [4, 5, 6, 7, 8, 9, 10, 11, 12]. |
| PubMedID- 23420139 | While in some patients the disease remained static, in a larger proportion a more severe disease developed characterized by portal hypertension, the latter leading to hypersplenism with neutropenia and thrombocytopenia and, in some cases, to ascites. |
| PubMedID- 23177370 | Background: consequences of extrahepatic portal vein obstruction (ehpvo) include variceal bleeding and hypersplenism due to portal hypertension, as well as metabolic abnormalities secondary to impaired portal venous circulation. |
| PubMedID- 20846792 | Knockdown of pik3r1 by shrna inhibits the activity of the splenic macrophages associated with hypersplenism due to portal hypertension. |
| PubMedID- 22277708 | hypersplenism due to portal hypertension: retrospective evaluation of 17 patients treated by splenic embolization. |
| PubMedID- 20407867 | This study examined the mrna expression of nalp3 in the spleen of the mice with hypersplenism due to portal hypertension (ph). |
| PubMedID- 22540086 | In addition, the underlying cirrhosis present in most patients may lead to portal hypertension with hypersplenism, platelet sequestration, varices and gastrointestinal bleeding, hepatic encephalopathy, hypoalbuminemia, differential drug binding and distribution, and altered pharmacokinetics, limiting the selection and adequate dosing of most cytotoxic agents. |
| PubMedID- 20927629 | Methods: case 1 was an 11-year-old boy diagnosed with rupture of the esophageal varices and hypersplenism due to congenital extrahepatic portal hypertension. |
| PubMedID- 25538966 | Common indications of pse include hypersplenism with portal hypertension, hereditary spherocytosis, thalassemia, autoimmune hemolytic anemia, splenic trauma, idiopathic thrombocytopenic purpura, splenic hemangioma, and liver cancer. |
| PubMedID- 24741213 | Mitra shunt (spleen preserving, side to side lieno-renal shunt) for portal hypertension with hypersplenism in early infancy. |
| PubMedID- 25788181 | Beta-blocker therapy ameliorates hypersplenism due to portal hypertension in children. |
| PubMedID- 25680200 | Cfld is characterized by cirrhosis and patients often present with splenomegaly, hypersplenism and complications of portal hypertension, including variceal bleeding and ascites [6,7]. |
| PubMedID- 22087192 | This is evidenced by the fact that thrombocytopenia in cirrhotic patients is not only attributed to hypersplenism due to portal hypertension but also resulted from decreased thrombopoeitin and interleukin-11 [1]. |
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