eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | polycystic ovary syndrome |
| Comorbidity | C0028754|obesity |
| Sentences | 61 |
| PubMedID- 21283731 | Given the high prevalence of obesity in women with pcos, it is crucial to investigate the genetic contribution the susceptibility loci for obesity make to pcos. |
| PubMedID- 22844280 | The most frequently anovulatory cycles are related to polycystic ovary syndrome (pcos) commonly associated with obesity and hormonal disturbances in the course of obesity. |
| PubMedID- 24742124 | Context: central obesity in polycystic ovary syndrome (pcos) is associated with increased inflammatory markers and increased risk for type 2 diabetes. |
| PubMedID- 24002403 | pcos is also associated with obesity, which itself is heavily influenced by genetic variants. |
| PubMedID- 26024975 | Increasing evidence suggests that non-alcoholic fatty liver disease (nafld) and polycystic ovary syndrome (pcos) are associated with obesity, insulin resistance, metabolic syndrome, cardiovascular disease, cirrhosis, and liver tumors. |
| PubMedID- 26291816 | Increased serum chemerin in pcos woman with or without obesity suggested that chemerin may be involved in the development of the pathogenesis of pcos. |
| PubMedID- 21197149 | Pharmacological treatment of obesity in patients with polycystic ovary syndrome. |
| PubMedID- 25660380 | Objective: pcos is associated with obesity and insulin resistance. |
| PubMedID- 24594504 | obesity in pcos patients can present in adolescence prior to menarche [130] suggesting that pcos dysregulation occurred long before puberty. |
| PubMedID- 24906976 | Context: central obesity in polycystic ovary syndrome (pcos) is associated with increased inflammatory markers and increased risk for type 2 diabetes. |
| PubMedID- 21819556 | # other disease refers to asthma, idiopathic seizures (n = 1), peptic ulcer disease (n = 1), obesity with polycystic ovaries (n = 1), hypercholesteremia (n = 1), benign prostatic hypertrophy (n = 1); gluten sensitive enteropathy (n = 1). |
| PubMedID- 26123797 | Introduction: polycystic ovary syndrome (pcos) is associated with obesity and insulin resistance. |
| PubMedID- 22589237 | Only in a part of the studies in pcos patients with obesity, metformin treatment without behavioral interventions decreased body mass index (bmi). |
| PubMedID- 24479991 | Poor quality diet is associated with overweight status and obesity in patients with polycystic ovary syndrome. |
| PubMedID- 20618344 | Objective: obesity is frequently associated with the polycystic ovary syndrome (pcos) and both conditions may impact on the health-related quality of life (hr-qol) of affected patients. |
| PubMedID- 24708600 | Other studies have found that obesity generates an increase of testosterone levels in pcos patients [20-22]. |
| PubMedID- 22536232 | pcos is often associated with both obesity and metabolic syndrome. |
| PubMedID- 25634659 | The results showed no significant association of the tnf-alpha (−308 g/a) polymorphism with obesity in patients with pcos (bmi ≥ 25 kg/m2 vs. bmi < 25 kg/m2) (aa + ga vs. gg: or = 0.94, 95% ci = 0.49–1.79; figure 3).table 2meta-analysis oftnf-alpha (−308 g/a)polymorphism and pcos riskcomparisonno. |
| PubMedID- 22829818 | The intrauterine milieu in pregnancy and the reproduction outcome of pcos patients with overweight or obesity are not clear. |
| PubMedID- 26327890 | obesity, an inherent element of the stein-leventhal syndrome is observed in 50-60% of women with pcos [27]. |
| PubMedID- 26136127 | Statistical analysis allowed observation of the association of the snp rs3842748, through its gc genotype, with obesity in pcos (p = 0.049; or ci95% 1,59 [1.00-2.51]) and in classical pcos (ypcos) (p = 0.010), as well as the correlation of the snp rs689 and the pair of haplotypes h1/h1 with higher levels of testosteronaemia in the pcos group, although this was at the limit of significance (p = 0.054) conclusion: these results are in accordance with some studies in literature and highlight the role of insulin gene vntr in complex metabolic disorders. |
| PubMedID- 21756079 | Pioglitazone reduces central obesity in polycystic ovary syndrome women. |
| PubMedID- 24390680 | There were no statistical differences among the different obesity standards of the pcos patients with different fshr polymorphisms (table 4). |
| PubMedID- 21984577 | Depression in pcos might be associated with obesity and metabolic abnormalities including insulin resistance and dyslipidemia. |
| PubMedID- 26464861 | In addition, obesity is highly associated with polycystic ovary syndrome and increases some of its features like hyperandrogenism, hirsutism, and infertility [75]. |
| PubMedID- 25880805 | Background: polycystic ovary syndrome (pcos) is associated with obesity and increased cardiovascular (cv) risk markers. |
| PubMedID- 23208318 | polycystic ovary syndrome (pcos) is often associated with obesity in women, and it has serious metabolic and reproductive health implications. |
| PubMedID- 25873949 | polycystic ovary syndrome (pcos) is associated with obesity and insulin resistance (ir), key features of nonalcoholic steatohepatitis (nash). |
| PubMedID- 24086769 | Association between snps in the t2d-related genes fto and mc4r and obesity was found in patients with pcos, however the snps were not associated with pcos itself [10]. |
| PubMedID- 22767467 | Background polycystic ovary syndrome (pcos) is closely associated with obesity but the prevalence of obesity varies between published studies. |
| PubMedID- 21244650 | Additionally, pcos is often associated with obesity and a subsequent increased risk for type 2 diabetes [4-6]. |
| PubMedID- 20724929 | Recent findings: several clinical trials examined metformin effectiveness on lipids, atherosclerosis and inflammatory markers, hormone levels, menstrual irregularities, ovulation induction, fertility, hirsutism, obesity parameters and quality of life in pcos women. |
| PubMedID- 23089573 | Results: the prevalence of obesity in adolescents with pcos was 27% (25/91). |
| PubMedID- 25419391 | Subgroup analysis revealed pcos women with obesity to have significantly higher serum ptx3 level than non-obese pcos subjects (p=0.012), non-obese controls (p=0.015) and obese controls (p=0.002). |
| PubMedID- 20092643 | Given the high prevalence of obesity in pcos and the compelling evidence for a substantial genetic background of both pcos and obesity, known obesity susceptibility genes emerge as eligible candidates that might also be involved in the development of pcos. |
| PubMedID- 24040195 | Subsequently 2 pcos women with obesity were excluded from the study due to multiple pregnancies. |
| PubMedID- 24466303 | Given the high prevalence of obesity in pcos, both diseases may share similar genetic background [9]. |
| PubMedID- 25878993 | [11] the risk of developing pcos rises with increasing obesity, as does the severity of insulin resistance, hyper insulinemia, and ovulatory dysfunction, and the prevalence of metabolic syndrome, glucose intolerance, risk factor for cardiovascular disease, and sleedapena[12] direct correlation between psa, hirsutism and hyperandrogenism state was shown in one study. |
| PubMedID- 22662009 | obesity increases the risk of co-morbidities associated with pcos, such as impaired glucose tolerance and type 2 diabetes mellitus, hyperlipidaemia and arterial hypertension [11]. |
| PubMedID- 24520334 | pcos is strongly associated with abdominal obesity and hyperlipidaemia; in one study, 43% of women with pcos had a higher risk of developing hyperinsulinemia, insulin resistance, and type 2 diabetes [1], [3], [4]. |
| PubMedID- 26188231 | Associations of menstrual cycle irregularities with age, obesity and phenotype in patients with polycystic ovary syndrome. |
| PubMedID- 24250624 | Pcos (polycystic ovarian syndrome) is associated with insulin resistance, obesity and disorders of lipid metabolism as well as infertility. |
| PubMedID- 23218400 | Association between inflammatory biomarker serum procalcitonin and obesity in women with polycystic ovary syndrome. |
| PubMedID- 24534286 | Conclusion(s): although polycystic ovary syndrome is associated with metabolic risk, obesity was the major determinant of cardiometabolic disturbances in reproductive-aged women. |
| PubMedID- 22376149 | In the present review, the consequence and treatment of obesity in women with pcos are discussed. |
| PubMedID- 26197851 | Hyperandrogenemia, hyperinsulinemia, and obesity affect 60-70% of patients with polycystic ovarian syndrome (pcos), who exhibit an altered endometrial insulin signaling. |
| PubMedID- 26373822 | The absence of impairment in glut4 translocation suggests that pcos patients with obesity and insulin resistance may benefit from exercise training. |
| PubMedID- 25881575 | The correlation of aromatase activity and obesity in women with or without polycystic ovary syndrome. |
| PubMedID- 25246891 | pcos patients with upper body obesity in comparison with patients with lower body obesity had lower shbg and higher fai, but not significantly. |
| PubMedID- 24829523 | It is the pathophysiology of polycystic ovaries along with obesity, which increases both the maternal and perinatal morbidity. |
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