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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease polycystic ovary syndrome
Comorbidity C0020459|hyperinsulinemia
Sentences 16
PubMedID- 25879001 pcos is also associated with hyperandrogenemia, hyperinsulinemia, insulin resistance (ir), diabetes, hirsutism, and obesity.
PubMedID- 20843777 In endometria from pcos women with hyperinsulinemia, reduced levels of wave family proteins could compromise the cell surface glut4 exposure and the consequent glucose uptake in this tissue.
PubMedID- 25899185 Methodology: patients who had been diagnosed polycystic ovarian syndrome (pcos) with hyperinsulinemia and conceived and continued pregnancy, were divided in two groups; 50 patients received metformin throughout pregnancy and 32 did not.
PubMedID- 23717068 polycystic ovaries are likely associated with ovarian hyperandrogenism, hyperinsulinemia, and altered intraovarian paracrine signaling [3,4].
PubMedID- 25109619 pcos is associated with hyperinsulinemia, which is known to impair fat oxidation.
PubMedID- 26197851 Endometria from obese pcos women with hyperinsulinemia exhibit altered adiponectin signaling.
PubMedID- 25242983 pcos is associated with hyperandrogenemia, hyperinsulinemia (10), and insulin resistance, as well as abdominal obesity, cardiovascular disease and obstructive sleep apnea (11), all factors hypothesized to be associated with increased activity of the sympathetic nervous system (10).
PubMedID- 24520442 pcos is associated with insulin resistance, hyperinsulinemia, and dyslipidemia, which may result in epc dysfunction.
PubMedID- 24696694 Dyslipidemia is one of the common metabolic abnormalities in pcos, which is associated with ir and hyperinsulinemia, which was also noted in our study (1, 2).
PubMedID- 24073009 Many of the classical components of pcos such as polycystic ovaries, insulin resistance with related hyperinsulinemia, central obesity, and hypertension are associated with increased sympathetic activity [73–76].
PubMedID- 24887156 It has been reported that metformin decreases local androgen synthesis in human ovarian cells [79,80], increases glut4 expression in endometrial cells from pcos women with hyperinsulinemia [81], inhibits cell proliferation [36,37], and induces cell cycle arrest and apoptosis [35] in type i ec cells, all of which have been proposed to occur through activation of ampk signaling [35-37,39,81,82].
PubMedID- 24228029 It is well known that insulin resistance and hyperinsulinemia are closely associated with pcos, and insulin-sensitizer drugs improve hirsutism in patients with pcos, while there are not enough data showing that patients with hi also have insulin resistance [14].
PubMedID- 21188021 Insulin resistance in pcos leads to hyperinsulinemia, which increases androgen production in the ovaries.
PubMedID- 22654525 Multiple logistic regression analysis was used to determine the association of pcos with hyperinsulinemia, adjusted for obesity, hyperandrogenemia, and lh/fsh ratios.
PubMedID- 22345770 [15–17] the metabolic syndrome present in 34% of american adults yields a risk of heart disease equivalent to smoking and in adults increases the risk of the development of diabetes 3.5-fold within five years[18–20] like obesity, pcos is associated with insulin resistance, hyperinsulinemia, and an.
PubMedID- 22587479 Therefore, it can be speculated that pcos patients with hyperinsulinemia probably present an enhanced mi to dci epimerization rate in the ovary that would result in an increased dci/mi ratio (i.e., overproduction of dci), and in a mi deficiency.

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