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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease pancytopenia
Comorbidity C0020532|hypersplenism
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PubMedID- 24584572 Dpm leads to progressive hepatic fibrosis and consecutive portal hypertension that causes hypersplenism with pancytopenia and esophageal varices with upper gastrointestinal bleeding [7, 13].
PubMedID- 20054587 Her past medical history was notable for chronic kasabach-merritt syndrome, hypersplenism with pancytopenia, and intermittent lower gastrointestinal bleeding resulting from colonic hemangiomas.
PubMedID- 25535533 The possible mechanisms suggested for pancytopenia include hypersplenism, granuloma formation in the bm, phagocytosis of formed elements by reticuloendothelial cells or bm depression due to associated septicemia[5].

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