eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | pancytopenia |
| Comorbidity | C0002874|aplastic anemia |
| Sentences | 5 |
| PubMedID- 24763404 | Targeted resequencing of 52 bone marrow failure genes in patients with aplastic anemia reveals an increased frequency of novel variants of unknown significance only in slx4. |
| PubMedID- 26535686 | Abnormal metabolites related to bone marrow failure in aplastic anemia patients. |
| PubMedID- 24829696 | Currently, the immune-mediated suppression of hematopoiesis has been considered as a potential etiology for bone marrow failure in patient’s with aplastic anemia, because more than half of aplastic anemia patients respond to immunosuppressive therapies, such as treatment with antithymocyte globulin or antilymphocyte globulin and cya. |
| PubMedID- 21747886 | In the present study, 2 of 20 patients showed pancytopenia consistent with aplastic anemia during follow-up, indicating a subgroup, in which isolated thrombocytopenia accompanied by hypocellular marrow can be a prodrome of aplastic anemia. |
| PubMedID- 24235838 | These have included cardiovascular events, particularly severe cardiac failure; hematologic events including aplastic anemia with pancytopenia or deficiency of any single hematocytologic component; hypersensitivity reactions including rash, anaphylactoid reaction, urticaria, and drug eruptions; a spectrum of autoimmune reactions ranging from the subclinical appearance of autoantibodies to a rare, lupus-like syndrome; neurologic events including new onset or exacerbation of clinical symptoms and radiologic evidence of demyelinating disease, including multiple sclerosis; and immune suppressive effects resulting in infections, particularly with opportunistic or other ubiquitous agents as well as malignancies, including lymphoma. |
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