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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease pancytopenia
Comorbidity C0002871|anemia
Sentences 21
PubMedID- 24960628 Hematopoietic cell transplantation (hct) can cure bone marrow failure in patients with fanconi anemia (fa), and it is generally accepted that these patients should receive low-intensity conditioning because of the underlying dna repair defect in their cells.
PubMedID- 26060650 pancytopenia, intensive anemia, poikilocytosis, erithrocytis anisocytosis and polychromatophilia progressed in blood analysis.
PubMedID- 24238033 Cbc reports of these patients showed moderate pancytopenia with normocytic normochromic anemia and normal reticulocyte count.
PubMedID- 24509510 At necropsy, recipients of ike5δ/δcd19-cre pre-b cells had pancytopenia with severe anemia (blood hemoglobin 4.8 ± 0.7 g/dl) that likely contributed to morbidity or death, while ike5δ/δcd2-cre recipients tended to develop hind-limb paralysis and malignant pleural effusions.
PubMedID- 24235838 These have included cardiovascular events, particularly severe cardiac failure; hematologic events including aplastic anemia with pancytopenia or deficiency of any single hematocytologic component; hypersensitivity reactions including rash, anaphylactoid reaction, urticaria, and drug eruptions; a spectrum of autoimmune reactions ranging from the subclinical appearance of autoantibodies to a rare, lupus-like syndrome; neurologic events including new onset or exacerbation of clinical symptoms and radiologic evidence of demyelinating disease, including multiple sclerosis; and immune suppressive effects resulting in infections, particularly with opportunistic or other ubiquitous agents as well as malignancies, including lymphoma.
PubMedID- 22893049 Investigations: the laboratory tests already arranged by the patients general practitioner showed a pronounced pancytopenia with megaloblastic anemia and hyperbilirubinemia.
PubMedID- 20661450 bone marrow failure in children with fanconi anemia is attributed to excessive apoptosis and subsequent failure of the hematopoietic stem cell compartment (reviewed in [56]).
PubMedID- 24778999 Organ infiltration by mc may lead not only to organomegaly, but also to impairment or even loss of organ function and in severe (high grade) disease, bone marrow failure with anemia, thrombocytopenia, and/or recurrent infections (due to neutropenia) may occur.
PubMedID- 21721367 We present a case of a young female who presented with iron deficiency anemia associated with pancytopenia that improved with iron replenishment after initial deterioration, the mechanism of which is also discussed in this case report.
PubMedID- 25995815 Hematologic manifestations of gd include pancytopenia with anemia, thrombocytopenia and less commonly leucopenia [14].
PubMedID- 24145274 Failure to recognize this rare association of pernicious anemia as a cause of pancytopenia had resulted in delay in treatment and neurological complication in our patient.
PubMedID- 23547077 Purpose: allogeneic hematopoietic cell transplantation (hct) can cure bone marrow failure in patients with fanconi anemia (fa).
PubMedID- 24127129 Paroxysmal nocturnal hemoglobinuria (pnh) is a rare hematological disorder that is often suspected in a patient presenting with non-immune hemolytic anemia associated with pancytopenia or venous thrombosis.
PubMedID- 26106590 Thrombocytopenia and pancytopenia, occurring in patients with fanconi anemia (fa), are interpreted either as progression to bone marrow failure or as developing myelodysplasia.
PubMedID- 24883202 Treatment was discontinued in three patients due to adverse events (hypertension; bone marrow depression; pancytopenia with hemolytic anemia) and in four patients due to serious adverse events (dialysis; sepsis with pneumonia, hemodialysis and renal failure; hypertension with angina pectoris; decreased hemoglobin with increased crp).
PubMedID- 24829696 Currently, the immune-mediated suppression of hematopoiesis has been considered as a potential etiology for bone marrow failure in patient’s with aplastic anemia, because more than half of aplastic anemia patients respond to immunosuppressive therapies, such as treatment with antithymocyte globulin or antilymphocyte globulin and cya.
PubMedID- 25628690 This article is aimed to present the case of an eight-year-old girl suffering from severe fanconi anemia with pancytopenia who underwent a dental extraction.
PubMedID- 21747886 In the present study, 2 of 20 patients showed pancytopenia consistent with aplastic anemia during follow-up, indicating a subgroup, in which isolated thrombocytopenia accompanied by hypocellular marrow can be a prodrome of aplastic anemia.
PubMedID- 20067547 The differentiation of megaloblastic anemia from other causes of pancytopenia involving the marrow requires bone marrow examination rather than using mpv as an indicator.
PubMedID- 22291499 On the other hand, pharmacological androgen therapy, such as for anemia due to bone marrow failure, or for endometriosis, is aimed at producing specific effects on specific tissues.
PubMedID- 24763404 Targeted resequencing of 52 bone marrow failure genes in patients with aplastic anemia reveals an increased frequency of novel variants of unknown significance only in slx4.

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