eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | palmoplantar keratosis |
| Comorbidity | C0031106|early-onset periodontitis |
| Sentences | 2 |
| PubMedID- 25057233 | Papillon-lefevre syndrome (pls) is an autosomal recessive genetic disorder characterized by palmoplantar hyperkeratosis associated with severe early-onset periodontitis and premature loss of primary and permanent teeth. |
| PubMedID- 22144846 | In 1924, two french physicians papillon and lefévre[1] described a brother and sister with a condition characterized by palmoplantar hyperkeratosis associated with severe, early-onset periodontitis and premature loss of primary and permanent teeth. |
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