eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | opitz g/bbb syndrome |
| Comorbidity | C0011847|diabetes |
| Sentences | 4 |
| PubMedID- 23156382 | [pathophysiology and therapeutic procedures for diabetes in cushing syndrome]. |
| PubMedID- 26321136 | However, the pathogenesis of dumping syndrome in patients with type 2 diabetes is not fully investigated. |
| PubMedID- 21993190 | diabetes in cushing syndrome: basic and clinical aspects. |
| PubMedID- 22096402 | Gender, viral load (>100,000 copies/ ml), diabetes, wasting syndrome, and weight loss (>10 pounds or 10%) did not notably affect renal risk.15 in the large french anrs co3 aquitaine cohort in 2588 hiv-infected patients in whom the median baseline cg-calculated egfr was 96 ml/min/1.73 m2, multivariate analysis showed that the occurrence of egfr < 80 ml/min/1.73 m2 was increased significantly by age >50 years compared with younger age groups (odds ratio [or] = 13.3, p < 0.0001), age 41–50 years compared with younger age groups (or = 2.5, p < 0.0001), baseline body mass index <22 (or = 3.8, p < 0.0001), female gender (or = 3.2, p < 0.0001), and tdf use for at least one year (or = 1.6, p = 0.0016).16 the swiss hiv cohort study compared time to a 10-ml/min/1.73 m2 reduction in cg-estimated egfr over 24 months in treatment-naïve patients or patients with treatment interruptions ≥ 12 months after starting either a tdf-based combination antiretroviral therapy (n = 363) or a tdf-sparing regimen (n = 715).13 in the multiple cox model, the risk of reaching the primary endpoint was increased most notably by concurrent diagnosis of diabetes mellitus (hazard ratio [hr] = 2.3, p = 0.008), tdf use (hr = 1.8, p = 0.0001) and boosted protease inhibitor use (hr = 1.7, p = 0.0001). |
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