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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease non-alcoholic fatty liver disease
Comorbidity C0023895|liver disease
Sentences 18
PubMedID- 20059344 Currently the most common chronic liver disease, affecting 30% of the western world, nafld may progress to cirrhosis and end-stage liver disease and may increase the risk of developing diabetes and cardiovascular disease.
PubMedID- 24833926 The global burden of chronic liver disease, with nafld and viral hepatitis, is significant.
PubMedID- 24667593 Children were classified as having suspected nafld if common causes of liver disease were excluded, alanine aminotransferase levels exceeded established thresholds (>22.1 iu/l for girls and >25.8 iu/l for boys), and elevated alanine aminotransferase levels were confirmed by repeat measurement.
PubMedID- 22934189 The coexistence of nafld with other liver diseases, especially with viral hepatitis, such as hepatitis b and c, modifies its natural history and makes diagnosis difficult [3].
PubMedID- 22915023 nafld, leading to chronic liver disease and liver failure, is characterized by deposits of fat in the liver, mainly in the form of triglycerides.
PubMedID- 25060399 Progression of liver disease in non-alcoholic fatty liver disease: a prospective clinicopathological follow-up study.
PubMedID- 24336007 There is some data indicating that cardiovascular complications are more common among patients with diabetes and nafld than in patients without liver disease.
PubMedID- 26355775 Based on the significant worldwide prevalence of obesity and diabetes, there is an increasing probability that nafld coexists with chronic liver disease of other etiologies, increasing the risk of hcc.
PubMedID- 23104318 Therefore, it is unavoidable that there will be an increasing trend of nafld co-existing with other liver diseases.
PubMedID- 22175908 Difference in malignancies of chronic liver disease due to non-alcoholic fatty liver disease or hepatitis c in japanese elderly patients.
PubMedID- 26441244 Non-alcoholic steatohepatitis (nash), as an extreme form of nafld, is associated with progressive liver disease and can lead to cirrhosis and ⁄ or hepatocellular carcinoma [1,2].
PubMedID- 22372457 Fatty liver disease includes non-alcoholic fatty liver disease (nafld) and alcoholic liver disease (ald), each of which is increasing in prevalence.
PubMedID- 22043839 Pharmacologic treatment seems to be important for these patients and for nafld cases with more advanced liver disease.
PubMedID- 23227248 Overall, patients with abnormal γ-gt serum levels had higher alt serum levels and, considering liver histological features, a more severe liver disease, in term of fibrosis in nafld, and of steatosis, inflammatory activity and fibrosis in both chc and chb (figure 1).
PubMedID- 26303130 Cost-effective evaluation of nonalcoholic fatty liver disease with nafld fibrosis score and vibration controlled transient elastography.
PubMedID- 21843565 The natural history of liver disease in those with nafld critically depends on liver histological changes.
PubMedID- 25509904 So it is important for patients at high risk for nafld or with existing liver disease to pay attention to their life style, proper balanced diet, and slow and gradual weight loss.
PubMedID- 24678423 To assess liver damage and hepatocyte apoptosis, we measured serum ck-18 levels, which have been recently reported to predict histological nash and severity of liver disease in patients with nafld [7, 26].

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