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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease neutropenia
Comorbidity C0040034|thrombocytopenia
Sentences 20
PubMedID- 25818822 The importance of this finding is highlighted when one notes that infections are a leading cause of death in sle patients.22 bacterial infections are the most common, followed by viral and fungal infections.22 in this sample, leukopenia was associated with lymphopenia, psychosis, thrombocytopenia and anti-dsdna.
PubMedID- 21455428 [9–11] typically, the platelet count falls to 80% of the normal and thrombocytopenia may be associated with neutropenia and anemia.
PubMedID- 20178634 Wiskott-aldrich syndrome is an x-linked disorder characterized by current infection, thrombocytopenia (with small platelets), neutropenia, eczema, high ige levels, a very high prevalence of autoimmunity (including arthropathy, vasculitis, and inflammatory bowel disease) and malignancy.
PubMedID- 23995076 Mellouli et al (n=47) reported one episode of severe thrombocytopenia with severe leucopenia that resolved after stopping hu, another episode of pancytopenia was attributed to parvovirus infection.
PubMedID- 22570800 Hematological abnormalities such as chronic disease anemia, leucopenia with lymphopenia, thrombocytopenia or, more rarely, pancytopenia, are frequently described [6].
PubMedID- 22047938 Patients usually manifest marked thrombocytopenia, often with anaemia and leucopenia, a leukemic phase, and bone marrow involvement in 80% of cases.
PubMedID- 21610706 Dose-limiting toxicities consisted exclusively of myelosuppression (neutropenia with or without thrombocytopenia), leading to a delay in initiation of cycle 2 dosing.
PubMedID- 22015492 It is well known that cobalamin deficiency may also cause thrombocytopenia together with anemia and leukopenia in children.
PubMedID- 21234295 thrombocytopenia occurred in 13% of the patients and leukopenia in 5% (all grades).
PubMedID- 21116412 Dose limiting toxicities according to the manufacturer’s spc: anc < 500/μl for more than five days or neutropenia associated with fever/infection; thrombocytopenia < 25.000/μl; bilirubin > uln; ap > 2.5× uln; ast/alt > 2.5× uln.
PubMedID- 21878124 Clinical studies have shown that the bleedings are caused by a massive thrombocytopenia, usually connected with a severe leukopenia and depletion of bone marrow cells, the latter may result in complete aplasia [1,5-7].
PubMedID- 23401442 The major toxicity was transient grades 3 to 4 thrombocytopenia (87% of patients); febrile neutropenia occurred in 12%.
PubMedID- 21899744 A leukaemic picture is invariably found, associated with prominent thrombocytopenia and variable degrees of anaemia and neutropenia [165].
PubMedID- 26332545 Treatment-related adverse events included grade 4 thrombocytopenia (in 18% of patients), grade 4 neutropenia (in 12%), grade 3 anemia (in 30%), and grade 1 or 2 elevation in levels of total bilirubin (in 12%), alkaline phosphatase (in 21%), and aspartate aminotransferase (in 27%).
PubMedID- 21949519 Thus, vsga or sga infants are particularly vulnerable to bleeding with thrombocytopenia or infection associated with neutropenia especially early after birth.
PubMedID- 22354536 Both dengue fever and sle have common manifestations of fever, arthralgia, rash, leucopenia with thrombocytopenia and serositis.
PubMedID- 24299473 Evans syndrome (es) is a rare hematological disease commonly defined by the combination of simultaneous or sequential autoimmune hemolytic anemia (aiha) and immune thrombocytopenia (itp) sometimes associated with neutropenia in the absence of known underlying etiology.
PubMedID- 21845438 Grade 3/4 thrombocytopenia occurred in 28% of patients, neutropenia in 34%.
PubMedID- 20960521 Grade 3/4 (according to national cancer institute common toxicity criteria [version 3.0]) thrombocytopenia occurred in 47% of patients, neutropenia in 63%, and anemia in 37% of patients.
PubMedID- 24489398 Adverse events included thrombocytopenia in 41% of dogs, neutropenia in 17% of dogs, and gastrointestinal toxicity in 13% of dogs.

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