eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | neutropenia |
| Comorbidity | C0019196|hepatitis c |
| Sentences | 5 |
| PubMedID- 21415945 | The implications of these data for interferon-related neutropenia in patients with chronic hepatitis c are not wholly clear. |
| PubMedID- PMC4034027 | Recent reports suggest that certain polymorphisms in type i ifn signaling molecules are associated with ifn-induced neutropenia and thrombocytopenia in patients with chronic hepatitis c. ifnγ binds to a cell-surface receptor composed of two transmembrane polypeptides ifgr1 and ifgr2 resulting in activation of the janus kinases jak1 and jak2, phosphorylation of stat1, formation of stat1 homodimers, and activation of a specific set of genes that encode the effector molecules responsible for mediating its biological activity. |
| PubMedID- 23171914 | Severe neutropenia in patients with chronic hepatitis c: a benign condition. |
| PubMedID- 24675038 | Feasibility of pegylated interferon and ribavirin in hepatitis c-related cirrhosis with neutropenia or thrombocytopenia. |
| PubMedID- 24257097 | Purpose of review: this review describes the pathogenesis and therapeutic implications of neutropenia in patients with hepatitis c. |
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