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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease neural tube defects
Comorbidity C0016412|folate deficiency
Sentences 8
PubMedID- 24823794 Moreover, the overexpression of (human)nat1 in mice provokes ntds usually associated with folate deficiency [32], [34], [35] and has complex effects on the incidence and severity of orofacial clefting [33].
PubMedID- 22975411 Objective: maternal folate deficiency is associated with neural tube defects (ntds), the most common congenital birth defect at maternity hospital, kathmandu, nepal.
PubMedID- 22303378 For instance, it is well-known that folate deficiency is associated with neural tube defects (ntd; daly et al., 1995), animal studies have indicated the necessity of sufficient methyl group availability for proper neural tube development (dunlevy et al., 2006), and hypomethylation of long interspersed nucleotide elements (line) and genomic dna has been associated with increased risk of ntds in humans (wang et al., 2010).
PubMedID- 24694212 Subtler effects include maternal micronutrient deficiencies, such as iron deficiency anemia [164], and conditions that directly affect the fetus, such as neural tube defects associated with folate deficiency [165].
PubMedID- 22443202 To reduce the incidence of neural tube defect pregnancies associated with folate deficiency, the us food and drug administration (fda) adopted requirements for folate fortification of many food products starting in 1996 [31].
PubMedID- 23127121 folate deficiency increases the risk of chronic diseases, including neural tube defects (ntds) in infants, megaloblastic anemia, cardiovascular disease, and some cancers in adults.
PubMedID- 24048206 In this mouse model, a potential impaired thymidylate biosynthesis is responsible for ntds only when associated with maternal folate deficiency.
PubMedID- 19824061 The current study suggests a further possible protective role for inositol supplementation, in ameliorating ntds resulting from folate deficiency.

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