eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | neural tube defects |
| Comorbidity | C0011847|diabetes |
| Sentences | 4 |
| PubMedID- 25516495 | Maternal diabetes increases the risk of neural tube defects (ntds), and caspase-dependent apoptosis and gene dysregulation are implicated in this disease process. |
| PubMedID- 23880312 | Preexisting maternal diabetes increases the risk of neural tube defects (ntds). |
| PubMedID- 22534324 | Maternal diabetes-induced neural tube defects (ntds) are associated with increased programmed cell death (apoptosis) in the neuroepithelium, which is related to intracellular nitrosative stress. |
| PubMedID- 25540130 | However, we did not detect ntds in association with diabetes, although interestingly, the only embryo that developed craniorachischisis (a characteristic phenotype of wnt-pcp mutants) was a daam1+/gt embryo that had been exposed to glucose, leading us to question whether this might have been provoked by the interaction between diabetes and the disruption of the wnt-pcp pathway during neural tube development. |
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